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Ensituximab (anti-MUC5AC), 其他 Mucin-5AC 的 OTHER

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 恒河猴(Rhesus monkey), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177900-100μg
100μg 现货 Stock Image
Ab177900-1mg
1mg 现货 Stock Image
Ab177900-5mg
5mg 现货 Stock Image
Ab177900-10mg
10mg 期货 Stock Image

基本信息

产品名称 Ensituximab (anti-MUC5AC), 其他 Mucin-5AC 的 OTHER
别名 恩妥昔单抗(抗 MUC5AC)
英文别名 Gastric mucin | Major airway glycoprotein | MUC-5AC | Mucin-5 subtype AC, tracheobronchial | TBM | Tracheobronchial mucin
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 MUC5AC
种属反应性 人(Human),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 其它
作用机制 其他 Mucin-5AC 的 OTHER

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.5kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 188.1kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1092658-06-4
分子类型 抗体

关联靶点(人)

MUC5AC Tbio 粘蛋白-5AC(Mucin-5AC) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Ensituximab (anti-MUC5AC) (Ab177900) - SEC
The purity of Ensituximab (anti-MUC5AC) (Ab177900) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1013111 分析证书 Ab177900
ZJ24F1013110 分析证书 Ab177900
ZJ24F1013109 分析证书 Ab177900
ZJ24F0505860 分析证书 Ab177900
ZJ24F0505861 分析证书 Ab177900
ZJ24F0505862 分析证书 Ab177900

引用文献

1. Meezaman, D D and 5 more authors..  (1994)  Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)..  The Journal of biological chemistry,  (29): [PMID:7513696]
2. Lesuffleur, T T and 7 more authors..  (1995)  Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells. The 3' end of MUC5AC?.  The Journal of biological chemistry,  (9): [PMID:7775418]
3. Klomp, L W LW, Van Rens, L L and Strous, G J GJ..  (1995)  Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains..  The Biochemical journal,  (15): [PMID:8948439]
4. Li, D D, Gallup, M M, Fan, N N, Szymkowski, D E DE and Basbaum, C B CB..  (1998)  Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts..  The Journal of biological chemistry,  (20): [PMID:9506983]
5. Buisine, M P MP and 5 more authors..  (1998)  Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family..  The Biochemical journal,  (15): [PMID:9620876]
6. Silverman, H S HS and 10 more authors..  (2001)  In vivo glycosylation of mucin tandem repeats..  Glycobiology,  [PMID:11445551]
7. Escande, F F, Aubert, J P JP, Porchet, N N and Buisine, M P MP..  (2001)  Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region..  The Biochemical journal,  (15): [PMID:11535137]
8. Van de Bovenkamp, Jeroen H B JH and 6 more authors..  (2003)  The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach..  Helicobacter,  [PMID:14535999]
9. Lidell, Martin E ME and Hansson, Gunnar C GC..  (2006)  Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin..  The Biochemical journal,  (1): [PMID:16787389]
10. Raman, Jayalakshmi J, Guan, Yu Y, Perrine, Cynthia L CL, Gerken, Thomas A TA and Tabak, Lawrence A LA..  (2012)  UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree..  Glycobiology,  [PMID:22186971]
11. Lira-Navarrete, Erandi and 14 more authors..  (2015)  Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation..  Nature communications,  (5): [PMID:25939779]
12. Simões, Filipa B and 7 more authors..  (2019)  TMEM16A chloride channel does not drive mucus production..  Life science alliance,  [PMID:31732694]

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