Glenzocimab (anti-GP6), 血小板糖蛋白 VI (GPVI) 抑制剂

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human)
亚型: Human IgG1
偶联: Unconjugated

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab177896-100μg	100μg	现货
Ab177896-1mg	1mg	现货
Ab177896-5mg	5mg	现货
Ab177896-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: GP6

Accession#:Q9HCN6 (1) Gene ID:51206 (1) GP6 (1)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	Glenzocimab (anti-GP6), 血小板糖蛋白 VI (GPVI) 抑制剂
别名	格仑佐西单抗（抗 GP6）
英文别名	Glycoprotein 6 \| GPVI
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
宿主种属	人(Human)
特异性	GP6
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	血小板糖蛋白 VI (GPVI) 抑制剂

产品属性

克隆类型	重组抗体
Format	Fab
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	48.29 kDa
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2101829-58-5
分子类型	抗体

关联靶点（人）

GP6 Tchem 血小板糖蛋白 VI(Platelet glycoprotein VI) (0 活性数据)

点击查看靶蛋白信息： GP6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Glenzocimab (anti-GP6) (Ab177896)

Glenzocimab (anti-GP6) (Ab177896) - ELISA
Immobilized hu-GPVI-ECD-IEGRMD-hFc at 2.0 μg/mL can bind Glenzocimab (anti-GP6) (Ab177896) with the EC ₅₀ of 67.06 ng/mL.

SEC: Glenzocimab (anti-GP6) (Ab177896)

Glenzocimab (anti-GP6) (Ab177896) - SEC
The purity of Glenzocimab (anti-GP6) (Ab177896) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F1215659	分析证书	Ab177896
ZJ24F1215658	分析证书	Ab177896
ZJ24F1215657	分析证书	Ab177896

引用文献

1. Bhunia SS, Misra A, Khan IA, Gaur S, Jain M, Singh S, Saxena A, Hohlfield T, Dikshit M, Saxena AK.. (2017) Novel Glycoprotein VI Antagonists as Antithrombotics: Synthesis, Biological Evaluation, and Molecular Modeling Studies on 2,3-Disubstituted Tetrahydropyrido(3,4-b)indoles.. J Med Chem, 60 (1): (322-337). [PMID:27996269] [10.1021/acs.jmedchem.6b01360]
2. Foster H,Wilson C,Philippou H,Foster R. (2020) Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis.. J Med Chem, 63 (21): (12213-12242). [PMID:32463237] [10.1021/acs.jmedchem.0c00262]
3. Tsuji, M M, Ezumi, Y Y, Arai, M M and Takayama, H H.. (1997) A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.. The Journal of biological chemistry, (19): [PMID:9295288]
4. Jandrot-Perrus, M M and 11 more authors.. (2000) Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.. Blood, (1): [PMID:10961879]
5. Ezumi, Y Y, Uchiyama, T T and Takayama, H H.. (2000) Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI.. Biochemical and biophysical research communications, (14): [PMID:11027634]
6. Kunicki, Thomas J TJ, Cheli, Yann Y, Moroi, Masaaki M and Furihata, Kenichi K.. (2005) The influence of N-linked glycosylation on the function of platelet glycoprotein VI.. Blood, (15): [PMID:16014566]
7. O'Connor, M N MN, Smethurst, P A PA, Farndale, R W RW and Ouwehand, W H WH.. (2006) Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen.. Journal of thrombosis and haemostasis : JTH, [PMID:16405521]
8. Horii, Katsunori K, Kahn, Mark L ML and Herr, Andrew B AB.. (2006) Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI.. Blood, (1): [PMID:16861347]
9. Mori, Jun J and 7 more authors.. (2008) G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.. The Journal of biological chemistry, (19): [PMID:18955485]
10. Dumont, Bénédicte B and 8 more authors.. (2009) Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.. Blood, (27): [PMID:19549989]
11. Arthur, J F JF and 7 more authors.. (2011) TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.. Journal of thrombosis and haemostasis : JTH, [PMID:20946164]
12. Hu, Houyuan H and 13 more authors.. (2011) GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.. PloS one, (28): [PMID:21552524]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Glenzocimab (anti-GP6), 血小板糖蛋白 VI (GPVI) 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器