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Astegolimab (anti-IL-1RL1), IL-33 受体(ST2)抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG2
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177886-100μg
100μg 现货 Stock Image
Ab177886-1mg
1mg 现货 Stock Image
Ab177886-5mg
5mg 现货 Stock Image
Ab177886-10mg
10mg 期货 Stock Image

基本信息

产品名称 Astegolimab (anti-IL-1RL1), IL-33 受体(ST2)抑制剂
别名 阿斯替格单抗(抗IL-1RL1)
英文别名 EC 3.2.2.6 | Protein ST2
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL1RL1
种属反应性 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 IL-33 受体(ST2)抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG2
轻链亚型 kappa
SDS-PAGE 26.1 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 189.3kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 2173054-79-8
分子类型 抗体

关联靶点(人)

IL1RL1 Tbio 白细胞介素-1受体类1(Interleukin-1 receptor-like 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

图片

Astegolimab (anti-IL-1RL1) (Ab177886) - ELISA
Immobilized Human-ST2-ECD-his at 2 μg/mL can bind Astegolimab (anti-IL-1RL1) (Ab177886) with the EC₅₀ of 28.29 ng/mL.

Astegolimab (anti-IL-1RL1) (Ab177886) - SEC
The purity of Astegolimab (anti-IL-1RL1) (Ab177886) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F0404101 分析证书 Ab177886
ZJ24F0404102 分析证书 Ab177886
ZJ24F0404103 分析证书 Ab177886

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引用文献

1. Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T.  (1992)  Nucleotide sequence of a complementary DNA for human ST2..  Biochim Biophys Acta,  1171  (2): (215-8).  [PMID:1482686]
2. Tominaga, S i Si and 5 more authors..  (1999)  Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM..  Biochemical and biophysical research communications,  (14): [PMID:10527832]
3. Li, H H and 7 more authors..  (2000)  The cloning and nucleotide sequence of human ST2L cDNA..  Genomics,  (1): [PMID:10936050]
4. Tago, K K and 6 more authors..  (2001)  Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V..  Biochemical and biophysical research communications,  (3): [PMID:11478810]
5. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE..  (2004)  An unappreciated role for RNA surveillance..  Genome biology,  [PMID:14759258]
6. Marvie, Pierrick P and 10 more authors..  (2010)  Interleukin-33 overexpression is associated with liver fibrosis in mice and humans..  Journal of cellular and molecular medicine,  [PMID:19508382]
7. Lingel, Andreas and 7 more authors..  (2009)  Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes..  Structure (London, England : 1993),  (14): [PMID:19836339]
8. Connolly, Dympna J DJ, O'Neill, Luke A J LA and McGettrick, Anne F AF..  (2013)  The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling..  The Journal of biological chemistry,  (22): [PMID:23319592]
9. Liu, Xi X and 7 more authors..  (2013)  Structural insights into the interaction of IL-33 with its receptors..  Proceedings of the National Academy of Sciences of the United States of America,  (10): [PMID:23980170]

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