Bersanlimab (anti-ICAM1)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human)
亚型: Human IgG1
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab176596-100μg	100μg	现货
Ab176596-1mg	1mg	现货
Ab176596-5mg	5mg	现货
Ab176596-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: ICAM1

Accession#:P05362 (5) CD54 (10) Gene ID:3383 (6) ICAM1 (7)

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基本信息

产品名称	Bersanlimab (anti-ICAM1)
别名	Bersanlimab（抗 ICAM1）
英文别名	ICAM-1 \| Major group rhinovirus receptor
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ICAM1
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	lambda
SDS-PAGE	27.2 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 191.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1987854-08-9
分子类型	抗体

关联靶点（人）

ICAM1 Tchem 细胞间粘附分子1(Intercellular adhesion molecule 1) (0 活性数据)

点击查看靶蛋白信息： ICAM1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Bersanlimab (anti-ICAM1) (Ab176596)

Bersanlimab (anti-ICAM1) (Ab176596) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ICAM1 with Bersanlimab (anti-ICAM1) (Ab176596) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Bersanlimab (anti-ICAM1) (Ab176596)

Bersanlimab (anti-ICAM1) (Ab176596) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ICAM1 (red) with Bersanlimab (anti-ICAM1) (Ab176596) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Bersanlimab (anti-ICAM1) (Ab176596)

Bersanlimab (anti-ICAM1) (Ab176596) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling ICAM1 (red) with Bersanlimab (anti-ICAM1) (Ab176596). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Bersanlimab (anti-ICAM1) (Ab176596)

Bersanlimab (anti-ICAM1) (Ab176596) - Flow Cytometry
Flow Cytometry analysis of Ramos cells labelling ICAM1 (red) with Bersanlimab (anti-ICAM1) (Ab176596). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Bersanlimab (anti-ICAM1) (Ab176596)

Bersanlimab (anti-ICAM1) (Ab176596) - SEC
The purity of Bersanlimab (anti-ICAM1) (Ab176596) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F1113306	分析证书	Ab176596
ZJ24F1113305	分析证书	Ab176596
ZJ24F1113304	分析证书	Ab176596
ZJ24F0404413	分析证书	Ab176596
ZJ24F0404411	分析证书	Ab176596
ZJ24F0404412	分析证书	Ab176596

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引用文献

1. Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR.. (2003) N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.. Bioorg Med Chem Lett, 13 (6): (1015-1018). [PMID:12643901] [10.1016/s0960-894x(03)00084-2]
2. Pei Z, Xin Z, Liu G, Li Y, Reilly EB, Lubbers NL, Huth JR, Link JT, von Geldern TW, Cox BF, Leitza S, Gao Y, Marsh KC, DeVries P, Okasinski GF.. (2001) Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.. J Med Chem, 44 (18): (2913-2920). [PMID:11520199] [10.1021/jm010059w]
3. Zhu GD, Arendsen DL, Gunawardana IW, Boyd SA, Stewart AO, Fry DG, Cool BL, Kifle L, Schaefer V, Meuth J, Marsh KC, Kempf-Grote AJ, Kilgannon P, Gallatin WM, Okasinski GF.. (2001) Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.. J Med Chem, 44 (21): (3469-3487). [PMID:11585452] [10.1021/jm0101702]
4. Lin Kc, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee WC, Hammond CE, Kalkunte S, Chen LL et al.. (1999) Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.. J Med Chem, 42 (5): (920-34). [PMID:10072689]
5. Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM.. (2010) Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.. Bioorg Med Chem Lett, 20 (17): (5269-5273). [PMID:20655213] [10.1016/j.bmcl.2010.06.145]
6. Voraberger, G G, Schäfer, R R and Stratowa, C C.. (1991) Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:1680919]
7. Marlin, S D SD and 5 more authors.. (1990) A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection.. Nature, (1): [PMID:1968231]
8. Stade, B G BG, Messer, G G, Riethmüller, G G and Johnson, J P JP.. (1990) Structural characteristics of the 5' region of the human ICAM-1 gene.. Immunobiology, [PMID:1983003]
9. Greve, J M JM and 7 more authors.. (1989) The major human rhinovirus receptor is ICAM-1.. Cell, (10): [PMID:2538243]
10. Tomassini, J E JE and 5 more authors.. (1989) cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2544880]
11. Simmons, D D, Makgoba, M W MW and Seed, B B.. (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.. Nature, (18): [PMID:3340213]
12. Staunton, D E DE, Marlin, S D SD, Stratowa, C C, Dustin, M L ML and Springer, T A TA.. (1988) Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.. Cell, (25): [PMID:3349522]
13. Vora, D K DK, Rosenbloom, C L CL, Beaudet, A L AL and Cottingham, R W RW.. (1994) Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster.. Genomics, [PMID:7525451]
14. Wenzel, K K, Ernst, M M, Rohde, K K, Baumann, G G and Speer, A A.. (1996) DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.. Human genetics, [PMID:8557254]
15. Fernandez-Reyes, D D and 7 more authors.. (1997) A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.. Human molecular genetics, [PMID:9259284]
16. Casasnovas, J M JM, Stehle, T T, Liu, J H JH, Wang, J H JH and Springer, T A TA.. (1998) A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.. Proceedings of the National Academy of Sciences of the United States of America, (14): [PMID:9539702]
17. Bella, J J, Kolatkar, P R PR, Marlor, C W CW, Greve, J M JM and Rossmann, M G MG.. (1998) The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand.. Proceedings of the National Academy of Sciences of the United States of America, (14): [PMID:9539703]
18. Halushka, M K MK and 8 more authors.. (1999) Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.. Nature genetics, [PMID:10391210]
19. Kolatkar, P R PR and 5 more authors.. (1999) Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor.. The EMBO journal, (15): [PMID:10562537]
20. Xiao, C C and 10 more authors.. (2001) Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.. Journal of virology, [PMID:11160747]
21. Coscoy, L L and Ganem, D D.. (2001) A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.. The Journal of clinical investigation, [PMID:11413168]
22. Shimaoka, Motomu M and 11 more authors.. (2003) Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.. Cell, (10): [PMID:12526797]
23. Walter, Nicole A R NA, Stebbing, Justin J and Messier, Walter W.. (2005) The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs).. Journal of theoretical biology, (7): [PMID:15572059]
24. Xiao, Chuan C and 7 more authors.. (2005) The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.. Structure (London, England : 1993), [PMID:16004874]
25. Hoer, Simon S, Smith, Lorraine L and Lehner, Paul J PJ.. (2007) MARCH-IX mediates ubiquitination and downregulation of ICAM-1.. FEBS letters, (9): [PMID:17174307]
26. van Buul, Jaap D JD and 6 more authors.. (2007) RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.. The Journal of cell biology, (24): [PMID:17875742]
27. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
28. Rocha-Perugini, V V and 7 more authors.. (2013) CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.. Molecular and cellular biology, [PMID:23858057]
29. Kang, Min-Woong MW and 10 more authors.. (2015) Nafamostat Mesilate Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production.. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, [PMID:25954127]
30. Zhang, Xiang X and 10 more authors.. (2016) Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis.. Scientific reports, (26): [PMID:27782122]
31. Gupta, Ramesh C; Lall, Rajiv; Srivastava, Ajay and Sinha, Anita.. (2019) Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory.. Frontiers in veterinary science, [PMID:31294035]
32. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]

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Bersanlimab (anti-ICAM1)

库存信息

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基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

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复溶计算器