Praluzatamab (anti-ALCAM)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Unconjugated

有货

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库存信息

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货号 (SKU)	包装规格	是否现货
Ab176226-100μg	100μg	现货
Ab176226-1mg	1mg	现货
Ab176226-5mg	5mg	现货
Ab176226-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: ALCAM

Accession#:Q13740 (5) ALCAM (7) CD166 (6) Gene ID:214 (6)

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基本信息

产品名称	Praluzatamab (anti-ALCAM)
别名	普罗妥单抗 \| 普拉鲁扎单抗 (抗 ALCAM)
英文别名	Activated leukocyte cell adhesion molecule antibody \| ALCAM antibody \| ALCAM protein antibody \| CD 166 antibody \| CD166 antibody \| CD166 antigen antibody \| CD166_HUMAN antibody \| FLJ3851 antibody \| FLJ38514 antibody \| MEMD antibody \| MGC71733 antibody \| a
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ALCAM
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 49.7 kDa (Heavy Chain), under reducing conditions; 172.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2145109-70-0
分子类型	抗体

关联靶点（人）

ALCAM Tbio CD166抗原(CD166 antigen) (0 活性数据)

点击查看靶蛋白信息： ALCAM

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Praluzatamab (anti-ALCAM) (Ab176226)

Praluzatamab (anti-ALCAM) (Ab176226) - ELISA
Immobilized Hu-ALCAM-His-293 at 2 μg/mL can bind Praluzatamab (anti-ALCAM) (Ab176226) with the EC₅₀ of 6.98 ng/mL.

SEC: Praluzatamab (anti-ALCAM) (Ab176226)

Praluzatamab (anti-ALCAM) (Ab176226) - SEC
The purity of Praluzatamab (anti-ALCAM) (Ab176226) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

引用文献

1. Bowen, M A MA and 9 more authors.. (1995) Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.. The Journal of experimental medicine, (1): [PMID:7760007]
2. Bajorath, J J, Bowen, M A MA and Aruffo, A A.. (1995) Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.. Protein science : a publication of the Protein Society, [PMID:8520490]
3. Skonier, J E JE, Bowen, M A MA, Emswiler, J J, Aruffo, A A and Bajorath, J J.. (1996) Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.. Biochemistry, (24): [PMID:8823162]
4. Degen, W G WG and 6 more authors.. (1998) MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).. The American journal of pathology, [PMID:9502422]
5. Zhang, Hui H, Li, Xiao-Jun XJ, Martin, Daniel B DB and Aebersold, Ruedi R.. (2003) Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.. Nature biotechnology, [PMID:12754519]
6. Gimferrer, Idoia I and 8 more authors.. (2004) Relevance of CD6-mediated interactions in T cell activation and proliferation.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15294938]
7. Ikeda, Koji K and Quertermous, Thomas T.. (2004) Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.. The Journal of biological chemistry, (31): [PMID:15496415]
8. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
9. Zimmerman, Aukje W AW and 5 more authors.. (2006) Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.. Blood, (15): [PMID:16352806]
10. Muzny, Donna M DM and 113 more authors.. (2006) The DNA sequence, annotation and analysis of human chromosome 3.. Nature, (27): [PMID:16641997]
11. Hassan, Namir J NJ and 7 more authors.. (2006) CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.. Molecular and cellular biology, [PMID:16914752]
12. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
13. Iolyeva, Maria M and 5 more authors.. (2013) Novel role for ALCAM in lymphatic network formation and function.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:23169771]
14. Escoda-Ferran, Cristina C and 8 more authors.. (2014) Modulation of CD6 function through interaction with Galectin-1 and -3.. FEBS letters, (25): [PMID:24945728]
15. Chappell, Paul E PE and 8 more authors.. (2015) Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.. Structure (London, England : 1993), (4): [PMID:26146185]
16. Xu, Zheng Z and 8 more authors.. (2018) ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:29263213]

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Praluzatamab (anti-ALCAM)

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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