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Glembatumumab (anti-GPNMB), 跨膜糖蛋白的结合剂 NMB 结合剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG2
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175888-100μg
100μg 现货 Stock Image
Ab175888-1mg
1mg 现货 Stock Image
Ab175888-5mg
5mg 现货 Stock Image
Ab175888-10mg
10mg 期货 Stock Image

基本信息

产品名称 Glembatumumab (anti-GPNMB), 跨膜糖蛋白的结合剂 NMB 结合剂
别名 格列巴单抗(抗 GPNMB)
英文别名 Hematopoietic growth factor inducible neurokinin-1 type
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 GPNMB
种属反应性 人(Human)
偶联 Unconjugated
作用类型 结合剂
作用机制 跨膜糖蛋白的结合剂 NMB 结合剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG2
轻链亚型 kappa
SDS-PAGE 145.56 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1020264-78-1
分子类型 抗体

关联靶点(人)

GPNMB Tbio 跨膜糖蛋白 NMB(Transmembrane glycoprotein NMB) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Glembatumumab (anti-GPNMB) (Ab175888) - ELISA
Immobilized huGPNMB-his at 2.0 μg/mL can bind Glembatumumab (anti-GPNMB) (Ab175888) with the EC₅₀ of 40.9 ng/mL.

Glembatumumab (anti-GPNMB) (Ab175888) - SEC
The purity of Glembatumumab (anti-GPNMB) (Ab175888) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1114087 分析证书 Ab175888
ZJ24F1114086 分析证书 Ab175888
ZJ24F1114085 分析证书 Ab175888
ZJ24F0404238 分析证书 Ab175888
ZJ24F0404237 分析证书 Ab175888
ZJ24F0404236 分析证书 Ab175888

引用文献

1. Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M et al..  (2010)  Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer..  Clin Cancer Res,  16  (7): (2147-56).  [PMID:20215530]
2. Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL et al..  (2006)  CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma..  Clin Cancer Res,  12  (4): (1373-82).  [PMID:16489096]
3. Kuan CT, Wakiya K, Dowell JM, Herndon 2nd JE, Reardon DA, Graner MW, Riggins GJ, Wikstrand CJ, Bigner DD.  (2006)  Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme..  Clin Cancer Res,  12  (7 Pt 1): (1970-82).  [PMID:16609006]
4. Weterman, M A MA and 6 more authors..  (1995)  nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts..  International journal of cancer,  (3): [PMID:7814155]
5. Bandari, Persis S PS and 9 more authors..  (2003)  Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P..  Regulatory peptides,  (28): [PMID:12609765]
6. Basrur, Venkatesha V and 12 more authors.. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins..  Journal of proteome research,  [PMID:12643545]
7. Chi, An A and 16 more authors..  (2006)  Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes..  Journal of proteome research,  [PMID:17081065]
8. Yang, Chi-Fan CF and 7 more authors..  (2018)  Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans..  American journal of human genetics,  (1): [PMID:29336782]

溶液计算器