Tarextumab (anti-NOTCH3), 缺口受体 2 抗体;缺口受体 3 抗体

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 小鼠(Mouse)
亚型: Human IgG2
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab175667-100μg	100μg	现货
Ab175667-1mg	1mg	现货
Ab175667-5mg	5mg	现货
Ab175667-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: NOTCH3 点击查看靶蛋白信息: NOTCH2

Accession#:Q9UM47 (1) Gene ID:4854 (1) notch receptor 2 Antibody (1) notch receptor 3 Antibody (1) NOTCH3 (1)

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基本信息

产品名称	Tarextumab (anti-NOTCH3), 缺口受体 2 抗体;缺口受体 3 抗体
别名	他瑞妥单抗 \| 塔瑞珠单抗（抗 NOTCH3）
英文别名	CADASIL antibody \| CASIL antibody \| NOTC3_HUMAN antibody \| Notch 3 antibody \| Notch 3 intracellular domain antibody \| Notch homolog 3 antibody \| Notch3 antibody \| CADASIL \| CASILneurogenic locus notch homolog protein 3 \| Notch (Drosophila) homolog 3 \| not
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	NOTCH3
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	缺口受体 2 抗体;缺口受体 3 抗体

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	kappa
SDS-PAGE	26.0 kDa (Light Chain) & 48.6 kDa (Heavy Chain), under reducing conditions; 162.7 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1359940-55-8
分子类型	抗体

关联靶点（人）

NOTCH3 Tchem 神经源性位点 Notch 同源蛋白 3(Neurogenic locus notch homolog protein 3) (0 活性数据)

点击查看靶蛋白信息： NOTCH3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NOTCH2 Tchem 神经源性位点 Notch 同源蛋白 2(Neurogenic locus notch homolog protein 2) (0 活性数据)

点击查看靶蛋白信息： NOTCH2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NOTCH3 Tchem Neurogenic locus notch homolog protein 3 (57 活性数据)

点击查看靶蛋白信息： NOTCH3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Tarextumab (anti-NOTCH3) (Ab175667)

Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Tarextumab (anti-NOTCH3) (Ab175667)

Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Tarextumab (anti-NOTCH3) (Ab175667)

Tarextumab (anti-NOTCH3) (Ab175667) - SEC
The purity of Tarextumab (anti-NOTCH3) (Ab175667) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1202013	分析证书	Ab175667
ZJ23F1202014	分析证书	Ab175667
ZJ24F1214799	分析证书	Ab175667
ZJ24F1214800	分析证书	Ab175667
ZJ24F1214798	分析证书	Ab175667

引用文献

1. Shan W, Balog A, Quesnelle C, Gill P, Han WC, Norris D, Mandal S, Thiruvenkadam R, Gona KB, Thiyagarajan K, Kandula S, McGlinchey K, Menard K, Wen ML, Rose A, White R, Guarino V, Shen DR, Cvijic ME, Ranasinghe A, Dai J, Zhang Y, Wu DR, Mathur A, Rampulla R, Trainor G, Hunt JT, Vite GD, Westhouse R, Lee FY, Gavai AV.. (2015) BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.. Bioorg Med Chem Lett, 25 (9): (1905-1909). [PMID:25857941] [10.1016/j.bmcl.2015.03.038]
2. Joutel, A A and 18 more authors.. (1996) Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.. Nature, (24): [PMID:8878478]
3. Joutel, A A and 11 more authors.. (1997) Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients.. Lancet (London, England), (22): [PMID:9388399]
4. Gray, G E GE and 9 more authors.. (1999) Human ligands of the Notch receptor.. The American journal of pathology, [PMID:10079256]
5. Dichgans, M M and 10 more authors.. (1999) Quantitative MRI in CADASIL: correlation with disability and cognitive performance.. Neurology, (22): [PMID:10227618]
6. Oberstein, S A SA and 7 more authors.. (1999) Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients. Dutch CADASIL Research Group.. Neurology, (10): [PMID:10371548]
7. Joutel, A A and 9 more authors.. (2000) Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL.. Neurology, (9): [PMID:10802807]
8. Dichgans, M M, Ludwig, H H, Müller-Höcker, J J, Messerschmidt, A A and Gasser, T T.. (2000) Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains.. European journal of human genetics : EJHG, [PMID:10854111]
9. Grigg, R R and 5 more authors.. (2000) Identification of a novel mutation C144F in the Notch3 gene in an Australian CADASIL pedigree.. Human mutation, [PMID:11058919]
10. Wu, L L and 5 more authors.. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.. Nature genetics, [PMID:11101851]
11. Escary, J L JL and 5 more authors.. (2000) Evaluation of DHPLC analysis in mutational scanning of Notch3, a gene with a high G-C content.. Human mutation, [PMID:11102981]
12. Oliveri, R L RL and 13 more authors.. (2001) A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings.. Archives of neurology, [PMID:11559313]
13. Joutel, A A and 12 more authors.. (2001) Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis.. Lancet (London, England), (15): [PMID:11755616]
14. Feuerhake, F F and 6 more authors.. (2002) Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL.. Acta neuropathologica, [PMID:11810186]
15. Arboleda-Velasquez, J F JF and 16 more authors.. (2002) C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke.. Neurology, (23): [PMID:12136071]
16. Kalimo, Hannu H, Ruchoux, Marie-Magdaleine MM, Viitanen, Matti M and Kalaria, Raj N RN.. (2002) CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia.. Brain pathology (Zurich, Switzerland), [PMID:12146805]
17. Wu, Lizi L, Sun, Tao T, Kobayashi, Karla K, Gao, Ping P and Griffin, James D JD.. (2002) Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.. Molecular and cellular biology, [PMID:12370315]
18. Moon, So-Young SY and 7 more authors.. (2003) A novel mutation (C67Y)in the NOTCH3 gene in a Korean CADASIL patient.. Journal of Korean medical science, [PMID:12589106]
19. Santa, Yo Y and 6 more authors.. (2003) Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis.. Journal of the neurological sciences, (15): [PMID:12810003]
20. Singhal, Sumeet S, Bevan, Steve S, Barrick, Tom T, Rich, Philip P and Markus, Hugh S HS.. (2004) The influence of genetic and cardiovascular risk factors on the CADASIL phenotype.. Brain : a journal of neurology, [PMID:15229130]
21. Rojas-Marcos, I I and 6 more authors.. (2004) Gene symbol: NOTCH3. Disease: CADASIL.. Human genetics, [PMID:15300988]
22. Peters, Nils N and 5 more authors.. (2004) CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk.. Experimental cell research, (1): [PMID:15350543]
23. Opherk, Christian C, Peters, Nils N, Herzog, Jürgen J, Luedtke, Rainer R and Dichgans, Martin M.. (2004) Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients.. Brain : a journal of neurology, [PMID:15364702]
24. Mykkänen, Kati K and 10 more authors.. (2004) Detection of the founder effect in Finnish CADASIL families.. European journal of human genetics : EJHG, [PMID:15378071]
25. Soong, B W BW, Lee, Yi-Chung YC and Lu, Yi-Chun YC.. (2005) Gene symbol: NOTCH3. Disease: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.. Human genetics, [PMID:15818833]
26. Peters, Nils N and 5 more authors.. (2005) Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies.. Archives of neurology, [PMID:16009764]
27. Zhang, Yanmei Y, Jia, Lijun L, Lee, Soo Jung SJ and Wang, Michael M MM.. (2007) Conserved signal peptide of Notch3 inhibits interaction with proteasome.. Biochemical and biophysical research communications, (30): [PMID:17292860]
28. Coleman, Mathew L ML and 12 more authors.. (2007) Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.. The Journal of biological chemistry, (17): [PMID:17573339]
29. Fouillade, Charles C and 8 more authors.. (2008) Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain.. Human mutation, [PMID:18273901]
30. Zheng, Xiaofeng X and 18 more authors.. (2008) Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.. Proceedings of the National Academy of Sciences of the United States of America, (4): [PMID:18299578]
31. Martignetti, John A JA and 27 more authors.. (2013) Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis.. American journal of human genetics, (6): [PMID:23731542]
32. Rutten, Julie W JW and 11 more authors.. (2013) Hypomorphic NOTCH3 alleles do not cause CADASIL in humans.. Human mutation, [PMID:24000151]
33. Guo, Ailan and 15 more authors.. (2014) Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.. Molecular & cellular proteomics : MCP, [PMID:24129315]
34. Gripp, Karen W KW and 12 more authors.. (2015) Truncating mutations in the last exon of NOTCH3 cause lateral meningocele syndrome.. American journal of medical genetics. Part A, [PMID:25394726]

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Tarextumab (anti-NOTCH3), 缺口受体 2 抗体;缺口受体 3 抗体

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器