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Natalizumab (anti-ITGA4), 整合素 α4β1;整合素 α4亚基(抗原CD49D;VLA-4受体α4亚基)抗体

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG4
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175611-100μg
100μg 现货 Stock Image
Ab175611-1mg
1mg 现货 Stock Image
Ab175611-5mg
5mg 现货 Stock Image
Ab175611-10mg
10mg 期货 Stock Image

基本信息

产品名称 Natalizumab (anti-ITGA4), 整合素 α4β1;整合素 α4亚基(抗原CD49D;VLA-4受体α4亚基)抗体
别名 那他珠单抗 | 那他珠单抗(抗 ITGA4)
英文别名 269C wild type antibody | Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody | CD49 antigen like family member D antibody | CD49 antigen-like family member D antibody | CD49d antibody | IA4 antibody | Integrin alpha 4 antibody | Integrin alpha 4 su
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 ITGA4
种属反应性 人(Human)
偶联 Unconjugated
作用类型 抑制剂
作用机制 整合素 α4β1;整合素 α4亚基(抗原CD49D;VLA-4受体α4亚基)抗体

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4
轻链亚型 kappa
SDS-PAGE 26.1 kDa (Light Chain) & 51.3 kDa (Heavy Chain), under reducing conditions; 192.7 kDa, under non-reducing conditions.
纯化方法 Protein A purified
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 189261-10-7
分子类型 抗体

关联靶点(人)

ITGA4 Tclin 整合素α-4(Integrin alpha-4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ITGB1 Tclin 整合素β-1(Integrin beta-1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ITGB1 Tclin Fibronectin receptor beta (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGA4 Tclin Integrin alpha-4 (295 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-4/beta-1 (2269 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGA4 Tclin Integrin alpha-4/beta-7 (610 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-5/beta-1 (686 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-V/beta-1 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha2/beta1 (69 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha1/beta1 complex (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-10/Integrin beta-1 (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITGB1 Tclin ITGA6-ITGB1 complex (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Natalizumab (anti-ITGA4) (Ab175611) - SEC
The purity of Natalizumab (anti-ITGA4) (Ab175611) is more than 95% verified by HPLC.

Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ25F0319003 分析证书 Ab175611
ZJ24F0606633 分析证书 Ab175611
ZJ24F0606632 分析证书 Ab175611
ZJ24F0606631 分析证书 Ab175611

引用文献

1. Mackay CR.  (2008)  Moving targets: cell migration inhibitors as new anti-inflammatory therapies..  Nat Immunol,  (9): (988-98).  [PMID:18711436]
2. Léger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM.  (1997)  Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis..  Hum Antibodies,  (1): (3-16).  [PMID:9265500]

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