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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175586-100μg |
100μg |
期货 ![]() |
| |
| Ab175586-1mg |
1mg |
期货 ![]() |
| |
| Ab175586-5mg |
5mg |
期货 ![]() |
| |
| Ab175586-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Lorvotuzumab mertansine (anti-NCAM1), 神经细胞粘附分子 1 结合剂的结合剂 |
|---|---|
| 别名 | 莫星-洛沃妥珠单抗 | Lorvotuzumab mertansine(抗 NCAM1) |
| 英文别名 | antigen MSK39 identified by monoclonal antibody 5.1H11 antibody | antigen recognized by monoclonal antibody 5.1H11 antibody | CD56 antibody | cell adhesion molecule, neural, 1 antibody | MSK 39 antibody | MSK39 antibody | N-CAM-1 antibody | NCAM 1 antibod |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | NCAM1 |
| 种属反应性 | 人(Human) |
| 偶联 | SMCC-DM1 |
| 作用类型 | 结合剂 |
| 作用机制 | 神经细胞粘附分子 1 结合剂的结合剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 145 kDa |
| 纯化方法 | Protein A purified |
| 纯度 | >90% (SDS-PAGE&SEC) |
| 物理外观 | Liquid |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 1008106-64-6 |
| 分子类型 | 抗体偶联药物 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 1. Ishitsuka K, Jimi S, Goldmacher VS, Ab O, Tamura K. (2008) Targeting CD56 by the maytansinoid immunoconjugate IMGN901 (huN901-DM1): a potential therapeutic modality implication against natural killer/T cell malignancy.. Br J Haematol, 141 (1): (129-31). [PMID:18279455] |
| 2. Lutz RJ, Whiteman KR. (2009) Antibody-maytansinoid conjugates for the treatment of myeloma.. MAbs, 1 (6): (548-51). [PMID:20068397] |
| 3. Lambert JM. (2013) Drug-conjugated antibodies for the treatment of cancer.. Br J Clin Pharmacol, 76 (2): (248-62). [PMID:23173552] |
| 4. van de Donk NW, Lokhorst HM. (2013) New developments in the management and treatment of newly diagnosed and relapsed/refractory multiple myeloma patients.. Expert Opin Pharmacother, 14 (12): (1569-73). [PMID:23721099] |
| 5. Whiteman KR, Johnson HA, Mayo MF, Audette CA, Carrigan CN, LaBelle A, Zukerberg L, Lambert JM, Lutz RJ. (2014) Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models.. MAbs, 6 (2): (556-66). [PMID:24492307] |