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Indusatumab vedotin (anti-GUCY2C), 鸟苷酸环化酶-C 抗体

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: MC-VC-PAB-MMAE
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175563-100μg
100μg 现货 Stock Image
Ab175563-1mg
1mg 现货 Stock Image
Ab175563-5mg
5mg 现货 Stock Image
Ab175563-10mg
10mg 期货 Stock Image

基本信息

产品名称 Indusatumab vedotin (anti-GUCY2C), 鸟苷酸环化酶-C 抗体
别名 维汀-英度妥单抗 | Indusatumab vedotin(抗 GUCY2C)
英文别名 GC-C antibody | Guanylyl cyclase C antibody | GUC2C antibody | GUC2C_HUMAN antibody | GUCY2C antibody | Heat stable enterotoxin receptor antibody | Heat-stable enterotoxin receptor antibody | hSTAR antibody | Intestinal guanylate cyclase antibody | STA re
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 GUCY2C
种属反应性 人(Human)
偶联 MC-VC-PAB-MMAE
作用类型 抑制剂
作用机制 鸟苷酸环化酶-C 抗体

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 145 kDa
纯化方法 Protein A purified
纯度 >90% (SDS-PAGE&SEC)
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1514889-12-3
分子类型 抗体偶联药物

关联靶点(人)

GUCY2C Tclin 热稳定肠毒素受体(Heat-stable enterotoxin receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Indusatumab vedotin (anti-GUCY2C) (Ab175563) - ELISA
Immobilized Recombinant Human GUCY2C protein ,His tag at 2.0 μg/mL can bind Indusatumab vedotin (anti-GUCY2C) (Ab175563) with the EC50 of 5.021 ng/mL.

Indusatumab vedotin (anti-GUCY2C) (Ab175563) - SEC
The purity of Indusatumab vedotin (anti-GUCY2C) (Ab175563) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1114633 分析证书 Ab175563
ZJ24F1114632 分析证书 Ab175563
ZJ24F1114631 分析证书 Ab175563
ZJ24F0809741 分析证书 Ab175563
ZJ24F0809740 分析证书 Ab175563
ZJ24F0809739 分析证书 Ab175563

引用文献

1. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA.  (2000)  Guanylyl cyclases and signaling by cyclic GMP..  Pharmacol Rev,  52  (3): (375-414).  [PMID:10977868]
2. Schulz S, Hyslop T, Haaf J, Bonaccorso C, Nielsen K, Witek ME, Birbe R, Palazzo J, Weinberg D, Waldman SA.  (2006)  A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer..  Clin Cancer Res,  12  (15): (4545-52).  [PMID:16899600]
3. Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA.  (2005)  Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract..  Hum Pathol,  36  (2): (170-9).  [PMID:15754294]
4. Almhanna K, Miron ML, Wright D, Gracian AC, Hubner RA, Van Laethem JL, López CM, Alsina M, Muñoz FL, Bendell J et al..  (2017)  Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C..  Invest New Drugs,  35  (2): (235-241).  [PMID:28188407]
5. Almhanna K, Wright D, Mercade TM, Van Laethem JL, Gracian AC, Guillen-Ponce C, Faris J, Lopez CM, Hubner RA, Bendell J et al..  (2017)  A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C..  Invest New Drugs,  35  (5): (634-641).  [PMID:28527133]
6. Carrithers SL, Barber MT, Biswas S, Parkinson SJ, Park PK, Goldstein SD, Waldman SA.  (1996)  Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues..  Proc Natl Acad Sci USA,  93  (25): (14827-32).  [PMID:8962140]

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