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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175560-100μg |
100μg |
现货 ![]() |
| |
| Ab175560-1mg |
1mg |
现货 ![]() |
| |
| Ab175560-5mg |
5mg |
现货 ![]() |
| |
| Ab175560-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Imaprelimab (anti-CD146), 黑色素瘤细胞粘附分子抗体 |
|---|---|
| 别名 | 伊普利单抗 | 伊马瑞单抗(抗 CD146) |
| 英文别名 | A32 antigen antibody | CD 146 antibody | CD146 antibody | CD146 antigen antibody | Cell surface glycoprotein MUC18 antibody | Cell surface glycoprotein P1H12 antibody | Gicerin antibody | Mcam antibody | Melanoma adhesion molecule antibody | Melanoma asso |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | MCAM |
| 种属反应性 | 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抗体 |
| 作用机制 | 黑色素瘤细胞粘附分子抗体 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 144.74 kDa |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2014343-04-3 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of A375 cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Imaprelimab (anti-CD146) (Ab175560) - SEC
The purity of Imaprelimab (anti-CD146) (Ab175560) is more than 95% verified by HPLC.
Imaprelimab (anti-CD146) (Ab175560) - ELISA
Immobilized Recombinant Human MCAM/CD146 Protein (rp183759) at 1.0 μg/mL can bind Imaprelimab (anti-CD146) (Ab175560) with the EC50 of 30.9 ng/mL.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab175560 | |
| 分析证书 | Ab175560 | |
| 分析证书 | Ab175560 | |
| 分析证书 | Ab175560 | |
| 分析证书 | Ab175560 |
| 1. Wu C, Goodall JC, Busch R, Gaston JS. (2015) Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-γ by CD4(+) T cells in patients with inflammatory arthritis.. Clin Exp Immunol, 179 (3): (378-91). [PMID:25113810] |
| 2. Dagur PK, McCoy Jr JP. (2015) Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.. Autoimmun Rev, 14 (5): (415-22). [PMID:25595133] |