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Belantamab mafodotin (anti-BCMA), B 细胞成熟抗原抗体

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: MC-VC-PAB-MMAF
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175467-100μg
100μg 现货 Stock Image
Ab175467-1mg
1mg 现货 Stock Image
Ab175467-5mg
5mg 现货 Stock Image
Ab175467-10mg
10mg 期货 Stock Image

基本信息

产品名称 Belantamab mafodotin (anti-BCMA), B 细胞成熟抗原抗体
别名 BCMA抗体 | BCMA单克隆抗体 | BCMA药靶抗体 | TNFRSF17抗体 | TNFRSF17单克隆抗体 | TNFRSF17药靶抗体 | CD269抗体 | CD269单克隆抗体 | CD269药靶抗体
英文别名 B cell maturation antigen antibody | B cell maturation factor antibody | B cell maturation protein antibody | B-cell maturation protein antibody | BCM antibody | BCMA antibody | CD269 antibody | CD269 antigen antibody | TNFRSF17 antibody | TNR17_HUMAN ant
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA
生化机理 Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
宿主种属 人(Human)
特异性 TNFRSF17
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 MC-VC-PAB-MMAF
作用类型 结合剂
作用机制 B 细胞成熟抗原抗体

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 145 kDa
纯化方法 Protein A purified
纯度 >90% (SDS-PAGE&SEC)
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 2050232-20-5
分子类型 抗体偶联药物

关联靶点(人)

TNFRSF17 Tclin 肿瘤坏死因子受体超家族成员 17(Tumor necrosis factor receptor superfamily member 17) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Belantamab mafodotin (anti-BCMA) (Ab175467) - Flow Cytometry
Flow Cytometry analysis of U266 cells labelling BCMA (red) with Belantamab mafodotin (anti-BCMA) (Ab175467) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Belantamab mafodotin (anti-BCMA) (Ab175467) - ELISA
Immobilized Recombinant Human BCMA/TNFRSF17(Fc) protein (rp169554) at 1.0 μg/mL can bind Belantamab mafodotin (anti-BCMA) (Ab175467) with the EC50 of 40.09 ng/mL.

Belantamab mafodotin (anti-BCMA) (Ab175467) - ELISA
Immobilized Recombinant huBCMA- ECD-His protein at 2.0 μg/mL can bind Belantamab mafodotin (anti-BCMA) (Ab175467) with the EC50 of 26.34 ng/mL.

Belantamab mafodotin (anti-BCMA) (Ab175467) - SEC
The purity of Belantamab mafodotin (anti-BCMA) (Ab175467) is more than 95% verified by HPLC.

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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ25F0723815 分析证书 Ab175467
ZJ25F0723816 分析证书 Ab175467
ZJ25F0723817 分析证书 Ab175467

引用文献

1. Nooka AK, Weisel K, van de Donk NW, Routledge D, Otero PR, Song K, Quach H, Callander N, Minnema MC, Trudel S et al..  (2021)  Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design..  Future Oncol,  17  (16): (1987-2003).  [PMID:33682447]
2. Popat R, Warcel D, O'Nions J, Cowley A, Smith S, Tucker WR, Yong K, Esposti SD.  (2020)  Characterization of response and corneal events with extended follow-up after belantamab mafodotin (GSK2857916) monotherapy for patients with relapsed multiple myeloma: a case series from the first-time-in-human clinical trial..  Haematologica,  105  (5): (e261-e263).  [PMID:32107339]

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