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Varlilumab (anti-TNFRSF7), CD27 抗原激动剂的 AGONIST

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 恒河猴(Rhesus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170646-100μg
100μg 现货 Stock Image
Ab170646-1mg
1mg 现货 Stock Image
Ab170646-5mg
5mg 现货 Stock Image
Ab170646-10mg
10mg 期货 Stock Image

基本信息

产品名称 Varlilumab (anti-TNFRSF7), CD27 抗原激动剂的 AGONIST
别名 伐立鲁单抗 | 瓦利珠单抗(抗肿瘤坏死因子-SF7)
英文别名 CD 27 antibody | CD27 antibody | CD27 antigen antibody | CD27 molecule antibody | CD27_HUMAN antibody | CD27L receptor antibody | LPFS2 antibody | MGC20393 antibody | OTTHUMP00000238557 antibody | S152 antibody | T cell activation antigen CD27 antibody |
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD27
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性 人(Human),恒河猴(Rhesus monkey)
偶联 Unconjugated
作用类型 激动剂
作用机制 CD27 抗原激动剂的 AGONIST

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.0 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1393344-72-3
分子类型 抗体

关联靶点(人)

CD27 Tbio CD27抗原(CD27 antigen) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Varlilumab (anti-TNFRSF7) (Ab170646) - Flow Cytometry
Flow Cytometry analysis of PBMC cells labelling TNFRSF7 (red) with Varlilumab (anti-TNFRSF7) (Ab170646). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Varlilumab (anti-TNFRSF7) (Ab170646) - SEC
The purity of Varlilumab (anti-TNFRSF7) (Ab170646) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ23F0900987 分析证书 Ab170646
ZJ24F0911256 分析证书 Ab170646
ZJ24F0911255 分析证书 Ab170646
ZJ23F0900986 分析证书 Ab170646

引用文献

1. Loenen, W A WA and 5 more authors..  (1992)  Genomic organization and chromosomal localization of the human CD27 gene..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:1334106]
2. Camerini, D D, Walz, G G, Loenen, W A WA, Borst, J J and Seed, B B..  (1991)  The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:1655907]
3. Prasad, K V KV and 6 more authors..  (1997)  CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein..  Proceedings of the National Academy of Sciences of the United States of America,  (10): [PMID:9177220]
4. Gravestein, L A LA and 5 more authors..  (1998)  The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2..  European journal of immunology,  [PMID:9692890]
5. van Montfrans, Joris M JM and 13 more authors..  (2012)  CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia..  The Journal of allergy and clinical immunology,  [PMID:22197273]
6. Salzer, Elisabeth E and 14 more authors..  (2013)  Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27..  Haematologica,  [PMID:22801960]

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