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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170646-100μg |
100μg |
现货 ![]() |
| |
| Ab170646-1mg |
1mg |
现货 ![]() |
| |
| Ab170646-5mg |
5mg |
现货 ![]() |
| |
| Ab170646-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Varlilumab (anti-TNFRSF7), CD27 抗原激动剂的 AGONIST |
|---|---|
| 别名 | 伐立鲁单抗 | 瓦利珠单抗(抗肿瘤坏死因子-SF7) |
| 英文别名 | CD 27 antibody | CD27 antibody | CD27 antigen antibody | CD27 molecule antibody | CD27_HUMAN antibody | CD27L receptor antibody | LPFS2 antibody | MGC20393 antibody | OTTHUMP00000238557 antibody | S152 antibody | T cell activation antigen CD27 antibody | |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | CD27 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human),恒河猴(Rhesus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 激动剂 |
| 作用机制 | CD27 抗原激动剂的 AGONIST |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1393344-72-3 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Varlilumab (anti-TNFRSF7) (Ab170646) - Flow Cytometry
Flow Cytometry analysis of PBMC cells labelling TNFRSF7 (red) with Varlilumab (anti-TNFRSF7) (Ab170646). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Varlilumab (anti-TNFRSF7) (Ab170646) - SEC
The purity of Varlilumab (anti-TNFRSF7) (Ab170646) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab170646 | |
| 分析证书 | Ab170646 | |
| 分析证书 | Ab170646 | |
| 分析证书 | Ab170646 |
| 1. Loenen, W A WA and 5 more authors.. (1992) Genomic organization and chromosomal localization of the human CD27 gene.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:1334106] |
| 2. Camerini, D D, Walz, G G, Loenen, W A WA, Borst, J J and Seed, B B.. (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:1655907] |
| 3. Prasad, K V KV and 6 more authors.. (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.. Proceedings of the National Academy of Sciences of the United States of America, (10): [PMID:9177220] |
| 4. Gravestein, L A LA and 5 more authors.. (1998) The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.. European journal of immunology, [PMID:9692890] |
| 5. van Montfrans, Joris M JM and 13 more authors.. (2012) CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.. The Journal of allergy and clinical immunology, [PMID:22197273] |
| 6. Salzer, Elisabeth E and 14 more authors.. (2013) Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27.. Haematologica, [PMID:22801960] |