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Sofituzumab (anti-MUC16)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 大鼠(Rat), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170584-100μg
100μg 现货 Stock Image
Ab170584-1mg
1mg 现货 Stock Image
Ab170584-5mg
5mg 现货 Stock Image
Ab170584-10mg
10mg 期货 Stock Image

基本信息

产品名称 Sofituzumab (anti-MUC16)
别名 索非妥珠单抗 | 索菲珠单抗(抗 MUC16)
英文别名 MMUC 1206A | Sofituzumab | CA 125 antibody | CA-125 antibody | CA125 antibody | CA125 ovarian cancer antigen antibody | Cancer antigen 125 antibody | FLJ14303 antibody | MUC 16 antibody | MUC-16 antibody | MUC16 antibody | MUC16_HUMAN antibody | Mucin 16
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 MUC16
应用 ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
种属反应性 人(Human),大鼠(Rat),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.9 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 180.9 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1615692-28-8
分子类型 抗体

关联靶点(人)

MUC16 Tbio 粘蛋白-16(Mucin-16) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Sofituzumab (anti-MUC16) (Ab170584) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling MUC16 (red) with Sofituzumab (anti-MUC16) (Ab170584). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Sofituzumab (anti-MUC16) (Ab170584) - SEC
The purity of Sofituzumab (anti-MUC16) (Ab170584) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ23F1001457 分析证书 Ab170584
ZJ23F1001460 分析证书 Ab170584
ZJ23F1001459 分析证书 Ab170584
ZJ23F1001458 分析证书 Ab170584
ZJ25F0420911 分析证书 Ab170584
ZJ25F0420910 分析证书 Ab170584

引用文献

1. Yin, B W BW and Lloyd, K O KO..  (2001)  Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16..  The Journal of biological chemistry,  (20): [PMID:11369781]
2. O'Brien, T J TJ and 5 more authors.. The CA 125 gene: an extracellular superstructure dominated by repeat sequences..  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,  [PMID:11786729]
3. O'Brien, Timothy J TJ, Beard, John B JB, Underwood, Lowell J LJ and Shigemasa, Kazushi K.. The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure..  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,  [PMID:12218296]
4. Kui Wong, Nyet N and 9 more authors..  (2003)  Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125..  The Journal of biological chemistry,  (1): [PMID:12734200]
5. Rump, Armin A and 6 more authors..  (2004)  Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion..  The Journal of biological chemistry,  (5): [PMID:14676194]
6. McLemore, Monica R MR and Aouizerat, Bradley B..  (2005)  Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer..  Biological research for nursing,  [PMID:15788735]
7. Argüeso, Pablo P, Tisdale, Ann A, Spurr-Michaud, Sandra S, Sumiyoshi, Mika M and Gipson, Ilene K IK..  (2006)  Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye..  Investigative ophthalmology & visual science,  [PMID:16384952]

溶液计算器