货号 (SKU)

包装规格

是否现货

价格

数量

Ab170548-100μg

100μg

期货

Ab170548-1mg

1mg

现货

Ab170548-5mg

5mg

现货

Ab170548-10mg

10mg

期货

基本信息

产品名称	Brentuximab (anti-TNFRSF8)
别名	布仑妥昔单抗（抗肿瘤坏死因子SF8）
英文别名	CD30L receptor \| Ki-1 antigen \| Lymphocyte activation antigen CD30
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	TNFRSF8
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	28.0 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 172.2 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2088770-90-3
分子类型	抗体

关联靶点（人）

TNFRSF8 Tclin 肿瘤坏死因子受体超家族成员 8(Tumor necrosis factor receptor superfamily member 8) (0 活性数据)

点击查看靶蛋白信息： TNFRSF8

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Brentuximab (anti-TNFRSF8) (Ab170548)

Brentuximab (anti-TNFRSF8) (Ab170548) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling TNFRSF8 (red) with Brentuximab (anti-TNFRSF8) (Ab170548). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Brentuximab (anti-TNFRSF8) (Ab170548)

Brentuximab (anti-TNFRSF8) (Ab170548) - SEC
The purity of Brentuximab (anti-TNFRSF8) (Ab170548) is more than 95% verified by HPLC.

ELISA: Brentuximab (anti-TNFRSF8) (Ab170548)

Brentuximab (anti-TNFRSF8) (Ab170548) - ELISA
Immobilized huCD30-his 2 μg/mL can bind Brentuximab (anti-TNFRSF8) (Ab170548) with the EC₅₀ of 6.00 ng/mL.

ELISA: Brentuximab (anti-TNFRSF8) (Ab170548)

Brentuximab (anti-TNFRSF8) (Ab170548) - ELISA
Immobilized Recombinant Human CD30 Protein (rp169577) at 1.0 μg/mL can bind Brentuximab (anti-TNFRSF8) (Ab170548) with the EC50 of 119.9 ng/mL.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	货号
ZJ23F0800942	分析证书	Ab170548
ZJ23F0800938	分析证书	Ab170548

技术文档和文章

流式细胞术实验方案

Categories: 实验方案（Protocols）

探索主题:

抗体流式细胞术流式抗体活性染料间接抗体标记

可替换产品

引用文献

1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells.. MAbs, 6 (3): (728-39). [PMID:24670809]
2. Dürkop, H H and 5 more authors.. (1992) Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.. Cell, (7): [PMID:1310894]
3. Jung, W W and 6 more authors.. (1994) Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources.. Molecular immunology, [PMID:7527901]
4. Smith, C A CA and 9 more authors.. (1993) CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.. Cell, (2): [PMID:8391931]
5. Lee, S Y SY, Park, C G CG and Choi, Y Y.. (1996) T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.. The Journal of experimental medicine, (1): [PMID:8627180]
6. Horie, R R and 9 more authors.. (1996) A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages.. Blood, (1): [PMID:8839832]
7. Aizawa, S S and 9 more authors.. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.. The Journal of biological chemistry, (24): [PMID:8999898]
8. Boucher, L M LM, Marengère, L E LE, Lu, Y Y, Thukral, S S and Mak, T W TW.. (1997) Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.. Biochemical and biophysical research communications, (28): [PMID:9168896]
9. Mizushima, S S and 8 more authors.. (1998) Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).. Gene, (30): [PMID:9511754]
10. Francisco, Joseph A JA and 14 more authors.. (2003) cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity.. Blood, (15): [PMID:12714494]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Brentuximab (anti-TNFRSF8)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Brentuximab (anti-TNFRSF8)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器