Evinacumab (anti-ANGPTL3), 血管生成素相关蛋白 3 抑制剂

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG4SP
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab169262-100μg	100μg	现货
Ab169262-1mg	1mg	现货
Ab169262-5mg	5mg	现货
Ab169262-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: ANGPTL3

Accession#:Q9Y5C1 (2) ANGPTL3 (2) Gene ID:27329 (2) 脂质代谢 (4331)

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基本信息

产品名称	Evinacumab (anti-ANGPTL3), 血管生成素相关蛋白 3 抑制剂
别名	依维苏单抗 \| 依维那库单抗(抗 ANGPTL3)
英文别名	Recombinant Evinacumab Antibody \| Anti-ANGPTL3 Reference Antibody \| Evinacumab \| REGN1500 \| Evinacumab(anti-ANGPTL3) \| ANG 5 antibody \| ANG-5 antibody \| ANG5 antibody \| Angiopoietin 5 antibody \| Angiopoietin like 3 antibody \| Angiopoietin related protein
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ANGPTL3
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	血管生成素相关蛋白 3 抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	27.1 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 177.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1446419-85-7
分子类型	抗体

关联靶点（人）

ANGPTL3 Tclin 血管生成素相关蛋白 3(Angiopoietin-related protein 3) (0 活性数据)

点击查看靶蛋白信息： ANGPTL3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

SEC: Evinacumab(anti-ANGPTL3) (Ab169262)

Evinacumab(anti-ANGPTL3) (Ab169262) - SEC
The purity of Evinacumab(anti-ANGPTL3) (Ab169262) is more than 95% verified by HPLC.

ELISA: Evinacumab (anti-ANGPTL3) (Ab169262)

Evinacumab (anti-ANGPTL3) (Ab169262) - ELISA
Immobilized huANGPTL3-chis at 2 μg/mL can bind Evinacumab (anti-ANGPTL3) (Ab169262) with the EC₅₀ of 283.8 ng/mL.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ25F0927182	分析证书	Ab169262
ZJ25F0927181	分析证书	Ab169262
ZJ23F0901032	分析证书	Ab169262
ZJ23F0901034	分析证书	Ab169262
ZJ24F0911278	分析证书	Ab169262
ZJ24F0911279	分析证书	Ab169262

技术文档和文章

流式细胞术实验方案

Categories: 实验方案（Protocols）

探索主题:

抗体流式细胞术流式抗体活性染料间接抗体标记

引用文献

1. Shimizugawa T, Ono M, Shimamura M, Yoshida K, Ando Y, Koishi R, Ueda K, Inaba T, Minekura H, Kohama T et al.. (2002) ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase.. J Biol Chem, 277 (37): (33742-8). [PMID:12097324]
2. Oike Y, Akao M, Kubota Y, Suda T. (2005) Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy.. Trends Mol Med, 11 (10): (473-9). [PMID:16154386]
3. Junchao Liu,Xia Gao,Yihui Zhai,Qian Shen,Li Sun,Chun Feng,Jia Rao,Haimei Liu,Xiliang Zha,Muyi Guo,Duan Ma,Zhigang Zhang,Ruixi Li,Hong Xu. (2015-02-25) A novel role of angiopoietin-like-3 associated with podocyte injury.. Pediatric research, 77 ((6)): (732-739). [PMID:25710887]
4. E-Chiang Lee,Urvi Desai,Gennady Gololobov,Seokjoo Hong,Xiao Feng,Xuan-Chuan Yu,Jason Gay,Nat Wilganowski,Cuihua Gao,Ling-Ling Du,Joan Chen,Yi Hu,Sharon Zhao,Laura Kirkpatrick,Matthias Schneider,Brian P Zambrowicz,Greg Landes,David R Powell,William K Sonnenburg. (2009-03-26) Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).. The Journal of biological chemistry, 284 ((20)): (13735-13745). [PMID:19318355]
5. Conklin, D D and 10 more authors.. (1999) Identification of a mammalian angiopoietin-related protein expressed specifically in liver.. Genomics, (15): [PMID:10644446]
6. Koishi, Ryuta R and 7 more authors.. (2002) Angptl3 regulates lipid metabolism in mice.. Nature genetics, [PMID:11788823]
7. Camenisch, Gieri G and 13 more authors.. (2002) ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.. The Journal of biological chemistry, (10): [PMID:11877390]
8. Shimamura, Mitsuru M and 8 more authors.. (2003) Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes.. Biochemical and biophysical research communications, (7): [PMID:12565906]
9. Ono, Mitsuru M and 7 more authors.. (2003) Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.. The Journal of biological chemistry, (24): [PMID:12909640]
10. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
11. Shimamura, Mitsuru M and 17 more authors.. (2007) Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.. Arteriosclerosis, thrombosis, and vascular biology, [PMID:17110602]
12. Hatsuda, Sawako S and 8 more authors.. (2007) Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects.. Journal of vascular research, [PMID:17191020]
13. Li, Yunling Y and 7 more authors.. (2008) Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3.. Acta biochimica et biophysica Sinica, [PMID:18535744]
14. Shan, Lu L and 6 more authors.. (2009) The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms.. The Journal of biological chemistry, (16): [PMID:19028676]
15. Romeo, Stefano S and 6 more authors.. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.. The Journal of clinical investigation, [PMID:19075393]
16. Sonnenburg, William K WK and 15 more authors.. (2009) GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4.. Journal of lipid research, [PMID:19542565]
17. Liu, Jun J, Afroza, Huq H, Rader, Daniel J DJ and Jin, Weijun W.. (2010) Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases.. The Journal of biological chemistry, (3): [PMID:20581395]
18. Schjoldager, Katrine T-B G KT and 7 more authors.. (2010) O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids.. The Journal of biological chemistry, (19): [PMID:20837471]
19. Musunuru, Kiran K and 26 more authors.. (2010) Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.. The New England journal of medicine, (2): [PMID:20942659]
20. Huijgen, Roeland R and 7 more authors.. (2012) Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels.. Human mutation, [PMID:22095935]
21. Schjoldager, Katrine T-B G KT and 10 more authors.. (2012) Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.. Proceedings of the National Academy of Sciences of the United States of America, (19): [PMID:22566642]
22. Quagliarini, Fabiana F and 9 more authors.. (2012) Atypical angiopoietin-like protein that regulates ANGPTL3.. Proceedings of the National Academy of Sciences of the United States of America, (27): [PMID:23150577]
23. Robciuc, Marius R MR and 14 more authors.. (2013) Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.. Arteriosclerosis, thrombosis, and vascular biology, [PMID:23661675]
24. Tikka, Anna A and 5 more authors.. (2014) Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation.. Bioscience reports, (12): [PMID:25495645]
25. Wang, Xiaoli X, Wang, Dongdong D and Shan, Zhongyan Z.. (2015) Clinical and genetic analysis of a family diagnosed with familial hypobetalipoproteinemia in which the proband was diagnosed with diabetes mellitus.. Atherosclerosis, [PMID:25733326]
26. Nidhina Haridas, P A PA and 16 more authors.. (2015) Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.. The Journal of clinical endocrinology and metabolism, [PMID:26204133]
27. Biterova, Ekaterina E, Esmaeeli, Mariam M, Alanen, Heli I HI, Saaranen, Mirva M and Ruddock, Lloyd W LW.. (2018) Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.. Scientific reports, (30): [PMID:29713054]
28. Banerjee, Poulabi and 11 more authors.. (2019) Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity.. Arteriosclerosis, thrombosis, and vascular biology, [PMID:31578082]
29. and Doggrell, Sheila A.. (2021) Will evinacumab become the standard treatment for homozygous familial hypercholesterolemia?. Expert opinion on biological therapy, [PMID:33295805]

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Evinacumab (anti-ANGPTL3), 血管生成素相关蛋白 3 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器