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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab098185-10μl |
10μl |
期货 ![]() |
| |
| Ab098185-50μl |
50μL |
期货 ![]() |
| |
| Ab098185-100μl |
100μL |
期货 ![]() |
| |
| Ab098185-1ml |
1ml |
期货 ![]() |
|
| 产品名称 | Cullin 4B/CUL-4B Mouse mAb |
|---|---|
| 别名 | CUL-4B抗体 | CUL4B蛋白抗体 |
| 英文别名 | CUL 4Bantibody | CUL-4B antibody | CUL4B antibody | CUL4B_HUMAN antibody | Cullin-4B antibody | DKFZp686F1470 antibody | KIAA0695 antibody | MRXHF2 antibody | MRXSC antibody | SFM2 antibody | SFM2 | MRXSC | CUL-4B | MRXHF2 | MRXS15 |
| 规格或纯度 | 见COA |
| 生化机理 | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. Post-translational: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. |
| 宿主种属 | 小鼠(Mouse) |
| 特异性 | CUL4B |
| 种属反应性 | 人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog) |
| 免疫原 | Recombinant protein of human CUL4B (AA 1-300). |
| 阳性对照 | WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human pancreas, thyroid, prostate tissues. |
| 偶联 | Unconjugated |
| 克隆类型 | 单克隆抗体 |
|---|---|
| Format | Whole IgG |
| SDS-PAGE | 150 kDa |
| 纯化方法 | Protein A/G purified |
| 物理外观 | Liquid |
| 储存缓冲液 | 10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3 |
| 防腐剂 | 0.02% Sodium azide |
| 浓度 | 见COA |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 短期储存2-8℃(1-2周);长期储存-20℃(12个月);收货后建议分装,避免反复冻融。 |
| 分子类型 | 抗体 |
| 应用名称 | 稀释比例 |
|---|---|
| WB | 1/2000 |
| IHC | 1/100 |