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Cullin 4B/CUL-4B Mouse mAb

    级别和纯度:
  • 见COA
    应用:
  • IHC
  • WB
  • 宿主种属: 小鼠(Mouse)
  • 种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse), 狗(Dog)
  • 亚型: Mouse IgG2b
  • 克隆号: OTI1C4
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab098185-10μl
10μl 期货 Stock Image
Ab098185-50μl
50μL 期货 Stock Image
Ab098185-100μl
100μL 期货 Stock Image
Ab098185-1ml
1ml 期货 Stock Image

基本信息

产品名称 Cullin 4B/CUL-4B Mouse mAb
别名 CUL-4B抗体 | CUL4B蛋白抗体
英文别名 CUL 4Bantibody | CUL-4B antibody | CUL4B antibody | CUL4B_HUMAN antibody | Cullin-4B antibody | DKFZp686F1470 antibody | KIAA0695 antibody | MRXHF2 antibody | MRXSC antibody | SFM2 antibody | SFM2 | MRXSC | CUL-4B | MRXHF2 | MRXS15
规格或纯度 见COA
生化机理 Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. Post-translational: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
宿主种属 小鼠(Mouse)
特异性 CUL4B
种属反应性 人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog)
免疫原 Recombinant protein of human CUL4B (AA 1-300).
阳性对照 WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human pancreas, thyroid, prostate tissues.
偶联 Unconjugated

产品属性

克隆类型 单克隆抗体
Format Whole IgG
SDS-PAGE 150 kDa
纯化方法 Protein A/G purified
物理外观 Liquid
储存缓冲液 10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂 0.02% Sodium azide
浓度 见COA
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 短期储存2-8℃(1-2周);长期储存-20℃(12个月);收货后建议分装,避免反复冻融。
分子类型 抗体

关联靶点(人)

CUL4B Tbio 库林-4B(Cullin-4B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

应用

应用名称 稀释比例
WB

1/2000

IHC

1/100

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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