| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A654666-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | AGN 192836 |
| 生化机理 | AGN 192836 是一种强效、选择性的 α2 肾上腺素能激动剂，对 α2A、α2B 和 α2C 受体的 EC 50 s 分别为 8.7、41 和 6.6 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 产品介绍 |
AGN 192836 is a potent and selective α2 adrenergic agonist with EC 50 s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively. In Vitro Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:α adrenergic receptor |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3 |
| PubChem CID | 10176999 |
| 分子量 | 231.25 |
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