Azadirachtin B

COA

级别和纯度:

≥99%

CAS编号: 106500-25-8
分子式: C₃₃H₄₂O₁₄
分子量: 662.68
PubChem编号: 21725521

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货号 (SKU)	包装规格	是否现货
A650785-1mg	1mg	期货
A650785-5mg	5mg	期货
A650785-10mg	10mg	期货

查看相关系列

Anti-infection (2804) Glucose Metabolism (3713) Influenza Virus (253) Metabolic Enzyme/Protease (4889) Parasite (1836) Phosphatase (222) Virus (3767)

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基本描述

别名	印楝素B
英文别名	AKOS040741190 \| HY-133108 \| AZADIRACHTIN B(SH) \| AZADIRACHTINB(P) \| dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-7,14-dihydroxy-6-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-12-[(E)-2-methyl
规格或纯度	≥99%
英文名称	Azadirachtin B
生化机理	Azadirachtin B 是一种从 Azadirachta indica 的种仁中分离出来的柠檬类化合物。Azadirachtin B 能提高碱性磷酸酶（ALP）活性，刺激成骨细胞分化。Azadirachtin B 对 Epstein-Barr 病毒早期抗原具有活性。
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica . Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA) . Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties In Vitro Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells. Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control. Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth ( Plutella xylostella ) with an LD 50 of 4.85-1.06 µg/g body weight, in 92 h. Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Osteoblast cells Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM Incubation Time: 48 hours Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells. In Vivo On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Plutella xylostella,Alkaline phosphatase (ALP),Epstein-Barr virus early antigen (EBV-EA)
纯度	≥99%

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关联靶点（其它种属）

Caenorhabditis elegans (1055 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Plutella xylostella (1838 活性数据)

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Athelia rolfsii (768 活性数据)

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Rhizoctonia solani (2251 活性数据)

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Rotylenchulus reniformis (56 活性数据)

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作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-7,14-dihydroxy-6-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-12-[(E)-2-methylbut-2-enoyl]oxy-3,9-dioxatetracyclo[6.6.1.01,5.011,15]pentadecane-4,11-dicarboxylate
INCHI	1S/C33H42O14/c1-7-14(2)24(36)45-17-11-16(34)30-12-44-20(25(37)40-5)21(30)28(3,23(35)19-22(30)31(17,13-43-19)26(38)41-6)33-18-10-15(29(33,4)47-33)32(39)8-9-42-27(32)46-18/h7-9,15-23,27,34-35,39H,10-13H2,1-6H3/b14-7+/t15-,16+,17-,18+,19-,20+,21+,22-,23-,27+,28+,29+,30-,31+,32+,33+/m1/s1
InChi Key	USRBWQQLHKQWAV-ZGKQVQOISA-N
Smiles	CC=C(C)C(=O)OC1CC(C23COC(C2C(C(C4C3C1(CO4)C(=O)OC)O)(C)C56C7CC(C5(O6)C)C8(C=COC8O7)O)C(=O)OC)O
Isomeric SMILES	C/C=C(\C)/C(=O)O[C@@H]1C[C@@H]([C@]23CO[C@@H]([C@H]2[C@]([C@@H]([C@H]4[C@H]3[C@@]1(CO4)C(=O)OC)O)(C)[C@@]56[C@@H]7C[C@H]([C@@]5(O6)C)[C@]8(C=CO[C@H]8O7)O)C(=O)OC)O
PubChem CID	21725521
分子量	662.68

化学和物理性质

溶解性	DMSO : 50 mg/mL (75.45 mM; Need ultrasonic)
分子量	662.700 g/mol
XLogP3	-0.400
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	14
可旋转键计数Rotatable Bond Count	8
精确质量Exact Mass	662.257 Da
单同位素质量Monoisotopic Mass	662.257 Da
拓扑极表面积Topological Polar Surface Area	189.000 Å²
重原子数Heavy Atom Count	47
形式电荷Formal Charge	0
复杂度Complexity	1490.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	16
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

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