AS1810722

COA

级别和纯度:

≥98%

CAS编号: 909561-15-5
分子式: C₂₅H₂₅F₂N₇O
分子量: 477.51
PubChem编号: 44208030

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货号 (SKU)	包装规格	是否现货
A647253-1mg	1mg	期货
A647253-5mg	5mg	期货
A647253-10mg	10mg	期货
A647253-25mg	25mg	期货
A647253-50mg	50mg	期货
A647253-100mg	100mg	期货

查看相关系列

Cytochrome P450 (243) JAK/STAT Signaling (508) Metabolic Enzyme/Protease (4889) STAT (138) Stem Cell/Wnt (1018) 脂质代谢 (4331)

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基本描述

规格或纯度	≥98%
英文名称	AS1810722
生化机理	AS1810722 是一种具有口服活性的强效 STAT6 抑制剂，IC 50 为 1.9 nM。AS1810722 对 CYP3A4 有良好的抑制作用。AS1810722 是融合双环嘧啶的衍生物，具有治疗过敏性疾病（如哮喘和特应性哮喘）的潜力。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	AS1810722 is an orally active and potent STAT6 inhibitor with an IC 50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research In Vitro AS1810722 (compound 24) inhibits production of IL-4 with an IC 50 of 2.4 nM, but shows no effect on production of IFN-γ. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AS1810722 (compound 24; 0.03-0.3 mg/kg; orally; 30 min before, and 24h and 48 h after OVA exposure) suppress eosinophil infiltration in the lung in a dose-dependent manner in an antigen-induced mouse asthmatic model . AS1810722 inhibits in vitro Th2 differentiation with an IC 50 of 2.4 nM without affecting type 1 helper T (Th1) cell differentiation and eosinophil infiltration in an antigen-induced mouse asthmatic model after oral administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Balb/c mice asthmatic model by intraperitoneal injection of ovalbumin (OVA)-containing aluminum hydroxide gel Dosage: 0.03-0.3 mg/kg Administration: Orally; 30 min before, and 24 and 48 h after OVA exposure Result: Suppressed eosinophil infiltration in the lung in a dose-dependent manner. Form:Solid IC50& Target:STAT6 1.9 nM (IC 50 ) CYP3A4
纯度	≥98%

关联靶点（人）

STAT6 Tchem 信号转导和转录激活因子 6(Signal transducer and activator of transcription 6) (1 活性数据)

点击查看靶蛋白信息： STAT6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	2-[4-[4-[[7-[(3,5-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]acetamide
INCHI	1S/C25H25F2N7O/c26-19-11-17(12-20(27)13-19)15-34-6-5-18-14-29-25(31-24(18)34)30-21-1-3-22(4-2-21)33-9-7-32(8-10-33)16-23(28)35/h1-6,11-14H,7-10,15-16H2,(H2,28,35)(H,29,30,31)
InChi Key	IJFRMEXSGYTWGY-UHFFFAOYSA-N
Smiles	C1CN(CCN1CC(=O)N)C2=CC=C(C=C2)NC3=NC=C4C=CN(C4=N3)CC5=CC(=CC(=C5)F)F
Isomeric SMILES	C1CN(CCN1CC(=O)N)C2=CC=C(C=C2)NC3=NC=C4C=CN(C4=N3)CC5=CC(=CC(=C5)F)F
PubChem CID	44208030
分子量	477.51

化学和物理性质

溶解性	DMSO : 62.5 mg/mL (130.89 mM; Need ultrasonic)

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