AM211, G 蛋白偶联受体 44 拮抗剂

COA

级别和纯度:

≥96%

CAS编号: 1175526-27-8
分子式: C₂₇H₂₇F₃N₂O₄
分子量: 500.51
PubChem编号: 44158492

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货号 (SKU)	包装规格	是否现货
A646543-5mg	5mg	现货
A646543-10mg	10mg	现货
A646543-50mg	50mg	现货
A646543-100mg	100mg	现货

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Class A GPCR (8201) GPCR/G Protein (3179) Prostaglandin Receptor (171)

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基本描述

英文别名	1175526-27-8 \| 2-(2'-((3-benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid \| 1175526-27-8 (free acid) \| AM211 free acid \| SZB129M7SZ \| AM211 \| AM-211 \| CHEMBL2181753
规格或纯度	≥96%
英文名称	AM211
生化机理	AM211 是一种强效、选择性和口服生物可用性的前列腺素 D2 (PGD2) 受体 2 型 (DP2) 拮抗剂，对人、小鼠、豚鼠和大鼠 DP2 的 IC 50 s 分别为 4.9 nM、7.8 nM、4.9 nM 和 10.4 nM。
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
作用类型	拮抗剂
作用机制	G 蛋白偶联受体 44 拮抗剂
产品介绍	AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC 50 s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. In Vitro AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC 50 s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. In the presence of 0.2% serum albumin, AM211 inhibits radiolabeled PGD2 binding to human, mouse, guinea pig, and rat DP2 with IC 50 values of 12.2, 20.1, 22.9, and 34.2 nM, respectively. AM211 displays high selectivity for DP2 versus other receptors in the prostanoid family, with IC 50 values for the inhibition of radioligand binding to human TP, IP, DP1, and FP of more than 100 μM. AM211 (100 μM) shows no activity at COX-1, COX-2 enzymes as well as PPAR family of nuclear receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED 50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 4.9 nM (Human DP2), 7.8 nM (Mouse DP2), 4.9 nM (Guinea pig DP2), 10.4 nM (Rat DP2)
纯度	≥96%

产品属性

ALogP	4.9

关联靶点（人）

PTGDR2 Tchem 前列腺素 D2 受体 2(Prostaglandin D2 receptor 2) (2 活性数据)

点击查看靶蛋白信息： PTGDR2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

PTGDR2 Tchem G protein-coupled receptor 44 (4688 活性数据)

点击查看靶蛋白信息： PTGDR2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	2-[3-[2-[[benzylcarbamoyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
INCHI	1S/C27H27F3N2O4/c1-3-32(26(35)31-16-18-7-5-4-6-8-18)17-20-15-21(27(28,29)30)10-11-22(20)23-13-19(14-25(33)34)9-12-24(23)36-2/h4-13,15H,3,14,16-17H2,1-2H3,(H,31,35)(H,33,34)
InChi Key	OPXIRFWNLBDKQB-UHFFFAOYSA-N
Smiles	CCN(CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=CC(=C2)CC(=O)O)OC)C(=O)NCC3=CC=CC=C3
Isomeric SMILES	CCN(CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=CC(=C2)CC(=O)O)OC)C(=O)NCC3=CC=CC=C3
关联CAS	1175526-27-8
PubChem CID	44158492
MeSH Entry Terms	(2'-(3-benzyl-1-ethylureidomethyl)-6-methoxy-4'-trifluoromethylbiphenyl-3-yl)acetic acid;AM 211;AM-211;AM211 cpd
分子量	500.51

化学和物理性质

溶解性	DMSO : ≥ 125 mg/mL (249.75 mM)
敏感性	对光敏感
分子量	500.500 g/mol
XLogP3	4.900
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	7
可旋转键计数Rotatable Bond Count	9
精确质量Exact Mass	500.192 Da
单同位素质量Monoisotopic Mass	500.192 Da
拓扑极表面积Topological Polar Surface Area	78.900 Å²
重原子数Heavy Atom Count	36
形式电荷Formal Charge	0
复杂度Complexity	714.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

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批号(Lot Number)	证书类型	货号
B2513147	分析证书	A646543
B2513189	分析证书	A646543
B2513143	分析证书	A646543
B2513144	分析证书	A646543
B2513145	分析证书	A646543
B2513146	分析证书	A646543
B2513148	分析证书	A646543
B2513190	分析证书	A646543