| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A471414-1g |
1g |
现货  |
|
| 英文别名 | 2-Amino-5-chlorobenzoxazole, 97% | NSC24995 | NSC-24995 | Zoxazolamine [INN:BAN:NF] | GTPL2327 | KBio3_002665 | Spectrum4_000624 | Zoxamine | ZOXAZOLAMINE [MI] | 2-amino-5-chloro-1,3-benzoxazole | NCGC00016280-07 | Prestwick3_000328 | SBI-0052854.P002 | Z |
|---|---|
| 规格或纯度 | 97% |
| 英文名称 | 2-Amino-5-chlorobenzoxazole |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-519-4 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 5-chloro-1,3-benzoxazol-2-amine |
| INCHI | 1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10) |
| InChi Key | YGCODSQDUUUKIV-UHFFFAOYSA-N |
| Smiles | C1=CC2=C(C=C1Cl)N=C(O2)N |
| Isomeric SMILES | C1=CC2=C(C=C1Cl)N=C(O2)N |
| 分子量 | 168.58 |
| Reaxy-Rn | 128223 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=128223&ln= |
| 分子量 | 168.580 g/mol |
|---|---|
| XLogP3 | 2.500 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 168.009 Da |
| 单同位素质量Monoisotopic Mass | 168.009 Da |
| 拓扑极表面积Topological Polar Surface Area | 52.100 Ų |
| 重原子数Heavy Atom Count | 11 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 155.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H312: 皮肤接触有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H332: 吸入有害 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | DM4550000 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 H2407289 |
分析证书 | A471414 |
| 1. Syme CA, Gerlach AC, Singh AK, Devor DC. (2000) Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.. Am J Physiol, Cell Physiol, 278 (3): (C570-81). [PMID:10712246] |
| 2. Jia Y, Guo GL, Surapureddi S, Sarkar J, Qi C, Guo D, Xia J, Kashireddi P, Yu S, Cho YW, Rao MS, Kemper B, Ge K, Gonzalez FJ, Reddy JK. (2005) Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.. Proc Natl Acad Sci USA, 102 (35): (12531-6). [PMID:16109766] |
| 3. Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism.. Nature, 407 (6806): (920-3). [PMID:11057673] |
| 4. W Tracewell,J Desjardins,P Iversen. (1995-12-01) In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides.. Toxicology and applied pharmacology, 135 ((2)): (179-184). [PMID:8545825] |
| 5. D J Hadjipavlou-Litina,A A Geronikaki. (1997-06-01) Effect of 2,4-disubstituted thiazol-5yl-aminoketones on inflammation. In vitro and in vivo biological studies: a structure-activity approach.. Research communications in molecular pathology and pharmacology, 96 ((3)): (307-318). [PMID:9261890] |
| 6. Cao Y, Dreixler JC, Roizen JD, Roberts MT, Houamed KM. (2001) Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.. J Pharmacol Exp Ther, 296 (3): (683-9). [PMID:11181893] |
| 7. B G Procter,C I Chappel. (1998-03-31) Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36 ((2)): (101-110). [PMID:9519848] |
| 8. B H Ali,A K Bashir,M O Tanira. (1999-11-05) The effect of Rhazya stricta Decne, a traditional medicinal plant, on spontaneous and drug-induced alterations in activity of rats.. Pharmacology, biochemistry, and behavior, 64 ((3)): (455-460). [PMID:10548255] |
| 9. A K Singh,D C Devor,A C Gerlach,M Gondor,J M Pilewski,R J Bridges. (2000-01-20) Stimulation of Cl(-) secretion by chlorzoxazone.. The Journal of pharmacology and experimental therapeutics, 292 ((2)): (778-787). [PMID:10640318] |
| 10. D E Lynch,D Daly,S Parsons. (2000-12-19) 2-Amino-5-chloro-1,3-benzoxazol-3-ium 2-(3,4-dichlorophenoxy)acetate.. Acta crystallographica. Section C, Crystal structure communications, 56 ((Pt 12)): (1478-1479). [PMID:11118996] |
| 11. I Andreadou,E A Rekka,P N Kourounakis. (2003-09-25) Effect of novel anti-inflammatory ethanolamine derivatives with antioxidant properties on drug metabolising enzymes.. European journal of drug metabolism and pharmacokinetics, 28 ((1)): (7-10). [PMID:14503659] |
| 12. Huidi Jiang,Guida Xuan. (2003-10-09) Effect of p-amino-diphenyl ethers on hepatic microsomal cytochrome P450.. Die Pharmazie, 58 ((9)): (654-656). [PMID:14531464] |
| 13. Juan P Hernandez,Laura M Chapman,Xiomara C Kretschmer,William S Baldwin. (2006-07-11) Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice.. Toxicology and applied pharmacology, 216 ((2)): (186-196). [PMID:16828826] |
| 14. B Singh,B K Chandan,N Sharma,V Bhardwaj,N K Satti,V N Gupta,B D Gupta,K A Suri,O P Suri. (2006-07-15) Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.. Phytotherapy research : PTR, 20 ((10)): (831-839). [PMID:16841368] |
| 15. Juan P Hernandez,Wendong Huang,Laura M Chapman,Steven Chua,David D Moore,William S Baldwin. (2007-05-08) The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.. Toxicological sciences : an official journal of the Society of Toxicology, 98 ((2)): (416-426). [PMID:17483497] |
| 16. Cong Zhang,Ana Maria Cuervo. (2008-08-12) Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.. Nature medicine, 14 ((9)): (959-965). [PMID:18690243] |
| 17. Junichiro Saito,Hiroko Fukushima,Hisamitsu Nagase. (2009-01-14) Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice.. Phytotherapy research : PTR, 23 ((7)): (901-905). [PMID:19140158] |
| 18. H C Liang,H Li,R A McKinnon,J J Duffy,S S Potter,A Puga,D W Nebert. (1996-02-20) Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.. Proceedings of the National Academy of Sciences of the United States of America, 93 ((4)): (1671-1676). [PMID:8643688] |
| 19. K K Anand,B Singh,A K Saxena,B K Chandan,V N Gupta,V Bhardwaj. (1998-01-13) 3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity.. Pharmacological research, 36 ((4)): (315-321). [PMID:9425622] |
| 20. P Pappas,P Stephanou,V Vasiliou,M Marselos. (1999-05-14) Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism.. European journal of drug metabolism and pharmacokinetics, 23 ((4)): (461-467). [PMID:10323328] |
| 21. A K Nyarko,N A Ankrah,M Ofosuhene,A A Sittie. (1999-12-14) Acute and subchronic evaluation of Indigofera arrecta: absence of both toxicity and modulation of selected cytochrome P450 isozymes in ddY mice.. Phytotherapy research : PTR, 13 ((8)): (686-688). [PMID:10594940] |
| 22. Joy Sarkar,Chao Qi,Dongsheng Guo,Mohamed R Ahmed,Yuzhi Jia,Nobuteru Usuda,Navin Viswakarma,M Sambasiva Rao,Janardan K Reddy. (2007-07-04) Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.. Gene expression, 13 ((4-5)): (255-269). [PMID:17605299] |
| 23. J P Hernandez,L C Mota,W Huang,D D Moore,W S Baldwin. (2008-12-02) Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).. Toxicology, 256 ((1-2)): (53-64). [PMID:19041682] |
| 24. Romi Ghose,Ozozoma Omoluabi,Adarsh Gandhi,Pranav Shah,Kelley Strohacker,Katie C Carpenter,Brian McFarlin,Tao Guo. (2011-05-31) Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters.. Life sciences, 89 ((1-2)): (57-64). [PMID:21620874] |
| 25. Anjana G Vij,Krishna Kishore,Joginder Dey. (2012-03-27) Effect of intermittent hypobaric hypoxia on efficacy & clearance of drugs.. The Indian journal of medical research, 135 (211-216). [PMID:22446863] |
| 26. Desirée M Möhner,Anne Bernhardt,Mohamed M Bekhite,P Christian Schulze,Heinrich Sauer,Maria Wartenberg. (2020-07-15) Zoxazolamine-induced stimulation of cardiomyogenesis from embryonic stem cells is mediated by Ca2+, nitric oxide and ATP release.. Biochimica et biophysica acta. Molecular cell research, 1867 ((11)): (118796-118796). [PMID:32663504] |
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