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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A466191-0.5ml |
0.5ml |
期货 ![]() |
|
| 英文别名 | (-) Anisomycin | 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate | Bio1_000839 | Antibiotic PA-106 | AKOS015916532 | BDBM63919 | DivK1c_000855 | NSC 76712 | (2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl acetate | 1,4,5-Trideoxy-1,4-imi |
|---|---|
| 规格或纯度 | 10mg/mL in DMSO |
| 英文名称 | Anisomycin, Ready Made Solution from Streptomyces griseolus |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 245-269-7 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate |
| INCHI | 1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
| InChi Key | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| Smiles | CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O |
| Isomeric SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O |
| UN Number | 3462 |
| 分子量 | 265.3 |
| Beilstein号 | 20705 |
| Reaxy-Rn | 221005 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=221005&ln= |
| 比旋光度 | -30° (C=1,MeOH) |
|---|---|
| 熔点 | 144 °C |
| 分子量 | 265.300 g/mol |
| XLogP3 | 0.900 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 265.131 Da |
| 单同位素质量Monoisotopic Mass | 265.131 Da |
| 拓扑极表面积Topological Polar Surface Area | 67.800 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 302.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P330: 漱口 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P361+P364: 立即脱掉所有沾染的衣服,清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽:立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | BZ9800000 |
| Merck Index | 670 |
| 个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
| 1. Zhang Y, Brown MR, Hyland C, Chen Y, Kronengold J, Fleming MR, Kohn AB, Moroz LL, Kaczmarek LK. (2012) Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.. J Neurosci, 32 (44): (15318-27). [PMID:23115170] |
| 2. Milton AL et al.. (2013) Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.. J Neurosci, 33 (3): (1109-15). [PMID:23325248] |
| 3. Liu X et al.. (2015) Mechanical Tension Promotes the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway.. Cell Physiol Biochem, 36 (2): (517-30). [PMID:25966835] |
| 4. Tran AP et al.. (2018) Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth.. J Neurosci, 38 (23): (5399-5414). [PMID:29760175] |
| 5. Einar Ö Einarsson,Karim Nader. (2012-09-18) Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory.. Learning & memory (Cold Spring Harbor, N.Y.), 19 ((10)): (449-452). [PMID:22984282] |
| 6. Jian-You Lin,Leslie Renee Amodeo,Joe Arthurs,Steve Reilly. (2012-10-16) Anisomycin infusions in the parabrachial nucleus and taste neophobia.. Neurobiology of learning and memory, 98 ((4)): (348-353). [PMID:23063932] |
| 7. Jonathan J Szalay,Chloe J Jordan,Kathleen M Kantak. (2012-10-31) Neural regulation of the time course for cocaine-cue extinction consolidation in rats.. The European journal of neuroscience, 37 ((2)): (269-277). [PMID:23106490] |
| 8. Stéphane Delmas,Iain G Duggin,Thorsten Allers. (2012-11-14) DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii.. Molecular microbiology, 87 ((1)): (168-179). [PMID:23145964] |
| 9. Ana Slipicevic,Geir Frode Øy,Anne Katrine Ree Rosnes,Øystein Stakkestad,Elisabeth Emilsen,Birgit Engesæter,Gunhild M Mælandsmo,Vivi Ann Flørenes. (2012-11-30) Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis.. Cancer biology & therapy, 14 ((2)): (146-154). [PMID:23192275] |
| 10. Jiajie Yan,Wei Kong,Qiang Zhang,Eric C Beyer,Gregory Walcott,Vladimir G Fast,Xun Ai. (2012-12-18) c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.. Cardiovascular research, 97 ((3)): (589-597). [PMID:23241357] |
| 11. Jociane de Carvalho Myskiw,Fernando Benetti,Iván Izquierdo. (2013-01-02) Behavioral tagging of extinction learning.. Proceedings of the National Academy of Sciences of the United States of America, 110 ((3)): (1071-1076). [PMID:23277583] |
| 12. Jia-Ying Chuang,Kuey-Yin Lin,Chianfang G Cherng,Lung Yu. (2013-01-04) Involvement of amygdaloid protein synthesis in early- and late-phase reconsolidation of emotion-related memories.. The Chinese journal of physiology, 55 ((5)): (314-322). [PMID:23282205] |
| 13. Laetitia Fellini,Fabio Morellini. (2013-01-18) Mice create what-where-when hippocampus-dependent memories of unique experiences.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 ((3)): (1038-1043). [PMID:23325241] |
| 14. Carlos V Melo,Miranda Mele,Michele Curcio,Diogo Comprido,Carla G Silva,Carlos B Duarte. (2013-01-18) BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons.. PloS one, 8 ((1)): (e53793-e53793). [PMID:23326507] |
| 15. Justin M Moscarello,Joseph E LeDoux. (2013-03-01) Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 ((9)): (3815-3823). [PMID:23447593] |
| 16. Takeshi H Saito,Shinsuke Uda,Takaho Tsuchiya,Yu-ichi Ozaki,Shinya Kuroda. (2013-03-08) Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression.. PloS one, 8 ((3)): (e57037-e57037). [PMID:23469182] |
| 17. Ayumi Kishioka,Takeshi Uemura,Fumiaki Fukushima,Masayoshi Mishina. (2013-04-17) Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum.. Molecular brain, 6 (17-17). [PMID:23587405] |
| 18. Filippo Andreetta,Nicholas M Barnes,Paul B Wren,Lucia Carboni. (2013-06-04) p38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms.. Life sciences, 93 ((1)): (30-37). [PMID:23727352] |
| 19. Sheng Yi,Fernando Pierucci-Alves,Bruce D Schultz. (2013-08-02) Transforming growth factor-β1 impairs CFTR-mediated anion secretion across cultured porcine vas deferens epithelial monolayer via the p38 MAPK pathway.. American journal of physiology. Cell physiology, 305 ((8)): (C867-C876). [PMID:23903699] |
| 20. Jieun Kim,Jeong-Tae Kwon,Hyung-Su Kim,Sheena A Josselyn,Jin-Hee Han. (2013-11-12) Memory recall and modifications by activating neurons with elevated CREB.. Nature neuroscience, 17 ((1)): (65-72). [PMID:24212670] |
| 21. Jiang-Yuan Hu,Samuel Schacher. (2014-04-04) Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 ((14)): (4776-4785). [PMID:24695698] |
| 22. Maile A Henson,Charles J Tucker,Meilan Zhao,Serena M Dudek. (2016-10-31) Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.. Neurobiology of learning and memory, 138 (39-53). [PMID:27794462] |
| 23. Varun Balaji,Senthilvelrajan Kaniyappan,Eckhard Mandelkow,Yipeng Wang,Eva-Maria Mandelkow. (2018-08-28) Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.. Autophagy, 14 ((12)): (2139-2154). [PMID:30145931] |
| 24. Anup Shrestha,Henrike Bruckmueller,Hanne Kildalsen,Gurjit Kaur,Matthias Gaestel,Hilde Ljones Wetting,Ingvild Mikkola,Ole-Morten Seternes. (2020-07-11) Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription.. Scientific reports, 10 ((1)): (11388-11388). [PMID:32647362] |
| 25. Kaiyu He,Hui-Ren Zhou,James J Pestka. (2012-10-02) Mechanisms for ribotoxin-induced ribosomal RNA cleavage.. Toxicology and applied pharmacology, 265 ((1)): (10-18). [PMID:23022514] |
| 26. Y Liu,J Ge,Q Li,L Gu,X Guo,Z G Ma,Y P Zhu. (2012-10-17) Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK.. Neoplasma, 60 ((1)): (101-110). [PMID:23067223] |
| 27. Matthew C Barrett,David F Sherry. (2012-10-17) Consolidation and reconsolidation of memory in black-capped chickadees (Poecile atricapillus).. Behavioral neuroscience, 126 ((6)): (809-818). [PMID:23067383] |
| 28. K L Shires,B M Da Silva,J P Hawthorne,R G M Morris,S J Martin. (2012-12-06) Synaptic tagging and capture in the living rat.. Nature communications, 3 (1246-1246). [PMID:23212375] |
| 29. Bo Ram Seo,Kyoung-Jin Min,Shin Kim,Jong-Wook Park,Won-Kyun Park,Tae-Jin Lee,Taeg Kyu Kwon. (2012-12-25) Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1.. Biochimie, 95 ((4)): (858-865). [PMID:23261849] |
| 30. Joanna Wawszczyk,Arkadiusz Orchel,Małgorzata Kapral,Andrzej Hollek,Ludmiła Weglarz. (2013-01-05) Phytic acid down-regulates IL-8 secretion from colonic epithelial cells by influencing mitogen-activated protein kinase signaling pathway.. Acta poloniae pharmaceutica, 69 ((6)): (1276-1282). [PMID:23285690] |
| 31. Louis C Leung,Vasja Urbančič,Marie-Laure Baudet,Asha Dwivedy,Timothy G Bayley,Aih Cheun Lee,William A Harris,Christine E Holt. (2013-01-08) Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation.. Nature neuroscience, 16 ((2)): (166-173). [PMID:23292679] |
| 32. Mehdi Hammadi,Agathe Oulidi,Florian Gackière,Maria Katsogiannou,Christian Slomianny,Morad Roudbaraki,Etienne Dewailly,Philippe Delcourt,Gilbert Lepage,Sabine Lotteau,Sylvie Ducreux,Natalia Prevarskaya,Fabien Van Coppenolle. (2013-01-17) Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27 ((4)): (1600-1609). [PMID:23322163] |
| 33. Cynthia Katche,Guido Dorman,Leandro Slipczuk,Martín Cammarota,Jorge H Medina. (2013-03-19) Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory.. Learning & memory (Cold Spring Harbor, N.Y.), 20 ((4)): (170-173). [PMID:23504514] |
| 34. Sharon A Swanger,Yuncen A He,Joel D Richter,Gary J Bassell. (2013-05-17) Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 ((20)): (8898-8908). [PMID:23678131] |
| 35. Peter C J Schmeits,Madhumohan R Katika,Ad A C M Peijnenburg,Henk van Loveren,Peter J M Hendriksen. (2013-11-20) DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells.. Toxicology letters, 224 ((3)): (395-406). [PMID:24247028] |
| 36. Hewen Qian, Yuanqing Ding, Xingyu Deng, Weiwei Huang, Zhenzhen Li, Fengling Liu, Jie Zhang, Lihui Wang, Junping Liu, Yaxia Yuan, Shurong Hou, Xiabin Chen, Lei Ma. (2023) Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 256 (115442). [PMID:37156184] [10.1016/j.ejmech.2023.115442] |
| 37. Bei Sun, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai. (2021) Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14. ACS Chemical Neuroscience, 12 (16): (3002–3014). [PMID:34369750] [10.1021/acschemneuro.1c00059] |
| 38. Yi Huang, Fengling Liu, Shuhua Ren, Yuanqing Ding, Man Chi, Weiwei Huang, Wenjing Gu, Hewen Qian, Yaxia Yuan, Shurong Hou, Xiabin Chen, Lei Ma. (2024) Structure Optimization of c-Jun N-terminal Kinase 1 Inhibitors for Treating Idiopathic Pulmonary Fibrosis. JOURNAL OF MEDICINAL CHEMISTRY, 67 (19): (17713-17737). [PMID:39303278] [10.1021/acs.jmedchem.4c01764] |