首页
400-620-6333
9篇引用文献 
计算溶液所需的质量、体积或浓度。
This is a demo store. No orders will be fulfilled.
7-氨基头孢烷酸
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A427127-1ml |
1ml |
现货  |
|
切换导航
关闭
搜索
基本描述
| 别名 | 7-氨基头孢霉烷酸 | 7-氨基头孢菌素酸 |
|---|---|
| 英文别名 | (6R,7R)-3-((ACETYLOXY)METHYL)-7-AMINO-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID | 7-amino cephalosporanic acid | 7-Aminocephalosporanic-acid | (6R,7R)-3-[(Acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic A |
| 规格或纯度 | 2mM in DMSO |
| 英文名称 | 7-Aminocephalosporanic acid |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
医药中间体。是许多半合成头孢菌素的起始原料。各种半合成头孢菌素的工业生产，是由发酵制得头孢菌素C。再用化学裂解获得母核7-ACA，然后进行化学改造的途径制取的。 产品应用
细菌（金黄色葡萄球菌）β-内酰胺酶的有效抑制剂。 Product Application |
关联靶点（人）
SLC15A1
Tchem
Oligopeptide transporter small intestine isoform
(922 活性数据)
关联靶点（其它种属）
Hdac6
Histone deacetylase 6 (222 活性数据)
Slc15a2
Oligopeptide transporter, kidney isoform (114 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 213-485-0 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (6R,7R)-3-(acetyloxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| INCHI | 1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1 |
| InChi Key | HSHGZXNAXBPPDL-HZGVNTEJSA-N |
| Smiles | CC(=O)OCC1=C(N2C(C(C2=O)N)SC1)C(=O)O |
| Isomeric SMILES | CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)N)SC1)C(=O)O |
| 分子量 | 272.28 |
| Beilstein号 | 622637 |
| Reaxy-Rn | 622637 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=622637&ln= |
化学和物理性质
| 比旋光度 | 90° (C=0.5,buffer sol. pH7.0 KH2PO4) |
|---|---|
| 熔点 | ＞300°C |
| 分子量 | 272.280 g/mol |
| XLogP3 | -4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 272.047 Da |
| 单同位素质量Monoisotopic Mass | 272.047 Da |
| 拓扑极表面积Topological Polar Surface Area | 135.000 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 461.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| WGK Germany | 3 |
| Merck Index | 434 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Weiwen Huang, Yichen Wang, Lumei Wang, Chaoqiang Pan, Guoqing Shen. (2021) Colorimetric detection of ciprofloxacin in aqueous solution based on an unmodified aptamer and the aggregation of gold nanoparticles. Analytical Methods, 13 (1): (90-98). [PMID:33300899] [10.1039/D0AY01811B] |
| 2. Yi Haoyang, Yan Zhiyu, Wang Lumei, Zhou Xiaotong, Yan Rui, Zhang Dongwei, Shen Guoqing, Zhou Shanshan. (2019) Fluorometric determination for ofloxacin by using an aptamer and SYBR Green I. MICROCHIMICA ACTA, 186 (10): (1-9). [PMID:31486902] [10.1007/s00604-019-3788-8] |
| 3. Yanyan Zhao, Yongbo Wang, Xuhua Liang, Huanxian Shi, Cunjin Wang, Jun Fan, Xiaoyun Hu, Enzhou Liu. (2019) Enhanced photocatalytic activity of Ag-CsPbBr3/CN composite for broad spectrum photocatalytic degradation of cephalosporin antibiotics 7-ACA. APPLIED CATALYSIS B-ENVIRONMENTAL, 247 (57). [10.1016/j.apcatb.2019.01.090] |
| 4. Xuan Ni, Bing Xia, Lumei Wang, Jing Ye, Gaoshang Du, Haiwei Feng, Xiaotong Zhou, Tong Zhang, Wenhao Wang. (2017) Fluorescent aptasensor for 17β-estradiol determination based on gold nanoparticles quenching the fluorescence of Rhodamine B. ANALYTICAL BIOCHEMISTRY, 523 (17). [PMID:28137603] [10.1016/j.ab.2017.01.021] |
| 5. Xiaotong Zhou,Lumei Wang,Guoqing Shen,Dongwei Zhang,Jialun Xie,Abdureyim Mamut,Weiwen Huang,Shanshan Zhou. (2018-07-05) Colorimetric determination of ofloxacin using unmodified aptamers and the aggregation of gold nanoparticles.. Mikrochimica acta, 185 ((7)): (355-355). [PMID:29971570] |
| 6. Wei-Chuang Kong, Chen-Chen Li, Ai-Hong Zhang, Xin-Long Li, Qian-Rui Gong, Bing-Tan Jin, Xiao-Juan Jia, Xu-Ying Liu, Yan-Fei Kang. (2024) A colorimetric-aptamer-based assay for the determination of enrofloxacin through triggering the aggregation of gold nanoparticles. Analytical Methods, [PMID:39311407] [10.1039/D4AY01259C] |
| 7. Wen-Yuan Fan, Xin Zhang, Dong-Hua Xie, Kenneth Mei Yee Leung, Guo-Ping Sheng. (2025) Cerium-based nanohydrolase for fast catalytic hydrolysis of β-lactam antibiotics in wastewater effluents. JOURNAL OF HAZARDOUS MATERIALS, 484 (136800). [PMID:39644848] [10.1016/j.jhazmat.2024.136800] |
| 8. Zhenbin Chen, Haohan Cai, Feng Huang, Zongping Wang, Yiqun Chen, Zizheng Liu, Pengchao Xie. (2024) Degradation of β-lactam antibiotics by Fe(III)/HSO3− system and their quantitative structure-activity relationship. ENVIRONMENTAL RESEARCH, 259 (119577). [PMID:38986801] [10.1016/j.envres.2024.119577] |
| 9. Shuqi Xing, Wei Xie, Guangli Hu, Chaocheng Luo, Hong Zhu, Laping He, Cuiqin Li, Xiao Wang, Xuefeng Zeng. (2025) The synthesis of cinnamyl acetate and deacetyl-7-aminocephalosporanic acid by a GDSL-type esterase and its substrate specificity analysis. ENZYME AND MICROBIAL TECHNOLOGY, 182 (110532). [PMID:39471645] [10.1016/j.enzmictec.2024.110532] |