| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A423478-1ml |
1ml |
现货  |
|
| 别名 | 1-硫醇-β-D-吡喃葡萄糖基三乙基膦金2,3,4,6-四乙酸酯, 3,4,5-三乙酰氧基-6-(乙酰氧基甲基)恶烷-2-硫醇盐三乙基磷, SKF 39162 | 金诺芬、 醋硫葡金 | 金诺芬 |
|---|---|
| 英文别名 | A937040 | 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium | D78135 | MFCD00080759 | 1-Thio- | (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate | BCP08217 | AURANOFIN | MMV688978 | 1-Thio-beta-D-glucop |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Auranofin |
| 生化机理 | 有机金化合物。抗炎和抗增殖剂。谷胱甘肽S-转移酶P1-1抑制剂（IC 50 = 33μM）。通过抑制STAT3表现出抗增殖作用。在体内显示抗炎作用。口服具有活性 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | TRPA1 激活剂 |
| 产品介绍 |
Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis. 金诺芬可在多个位点抑制白细胞活化途径，还可抑制人巨噬细胞、嗜碱性粒细胞和肺肥大细胞释放炎症介质。 金诺芬还可修饰IKKβ亚基5的Cys-179和参与氧化应激防御的硒酶硫氧还蛋白还原酶（TrxR），从而抑制人嗜中性粒细胞5-脂氧合酶和IKB激酶（IKK）。 金诺芬是一种改善病情的抗风湿药（DMARD），可用于研究抗OVCAR-3人卵巢癌细胞增殖作用。 Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis. Auranofin inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin also inhibits 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5 and selenoenzyme thioredoxin reductase (TrxR) which is involved in the defense against oxidative stress. Auranofin is a disease-modifying antirheumatic drug (DMARD) and has been used to study the anti-proliferative effects against OVCAR-3 human ovarian carcinoma cells. |
| IIUPAC Name | gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane |
|---|---|
| INCHI | 1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1 |
| InChi Key | AUJRCFUBUPVWSZ-UHFFFAOYSA-M |
| Smiles | CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+] |
| Isomeric SMILES | CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+] |
| 分子量 | 678.48 |
| Reaxy-Rn | 16134185 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=16134185&ln= |
| 敏感性 | 对湿度敏感;对光敏感 |
|---|---|
| 熔点 | 112-155℃ |
| 分子量 | 678.500 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 10 |
| 可旋转键计数Rotatable Bond Count | 12 |
| 精确质量Exact Mass | 678.133 Da |
| 单同位素质量Monoisotopic Mass | 678.133 Da |
| 拓扑极表面积Topological Polar Surface Area | 115.000 Ų |
| 重原子数Heavy Atom Count | 32 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 532.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 5 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 3 |
| 1. Li Jian-Guo, Zhang Chuan-Jian, Liang Liu-Yan, Lu Ting-Yin, Zhong Long-Gen, Zhong Wei-Cheng, Niu Chao-Yan, Sun Jian, Liao Xiao-Ping, Zhou Yu-Feng. (2024) Assessment of anti-MRSA activity of auranofin and florfenicol combination: a PK/PD analysis. JOURNAL OF APPLIED MICROBIOLOGY, 135 (12): [PMID:39694699] [10.1093/jambio/lxae299] |
| 2. Hao Liu, Ke Huang, Hao Zhang, Xiaohui Liu, Hui Jiang, Xuemei Wang. (2024) Photo-Driven In Situ Solidification of Whole Cells through Inhibition of Trogocytosis for Immunotherapy. Research, 7 (2024 Feb;7). [PMID:38384327] [10.34133/research.0318] |
首页
400-620-6333
2篇引用文献 
