| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A421035-1ml |
1ml |
现货  |
|
| 别名 | 杜鹃花酸 | 1,7-庚二甲酸 |
|---|---|
| 英文别名 | azelaic acid | NONANEDIOIC ACID | 123-99-9 | Finacea | Anchoic acid | Azelex | Lepargylic acid | 1,7-Heptanedicarboxylic acid | Skinoren | 1,9-Nonanedioic acid | Heptanedicarboxylic acid | n-Nonanedioic acid | Emerox 1110 | Emerox 1144 | azelate | acide azelaique | acidum azelaicum | Fine |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Azelaic acid |
| 生化机理 | 5α还原酶抑制剂。PPARγ激活剂。竞争性地抑制酪氨酸酶和硫氧还蛋白还原酶（K i值分别为3 mM和13μM）。细胞毒素为黑色素细胞。减少皮肤色素沉着。诱导水杨酸在植物中的积累。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. |
| ALogP | 1.6 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 204-669-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | nonanedioic acid |
| INCHI | 1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) |
| InChi Key | BDJRBEYXGGNYIS-UHFFFAOYSA-N |
| Smiles | C(CCCC(=O)O)CCCC(=O)O |
| Isomeric SMILES | C(CCCC(=O)O)CCCC(=O)O |
| 分子量 | 188.22 |
| Beilstein号 | 1101094 |
| Reaxy-Rn | 1101094 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1101094&ln= |
| 敏感性 | 对湿度敏感 |
|---|---|
| 折光率 | 1.4303 |
| 闪点(℉) | 410 °F |
| 闪点(℃) | 210 °C |
| 沸点 | 286°C |
| 熔点 | 109-111°C |
| 分子量 | 188.220 g/mol |
| XLogP3 | 1.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 188.105 Da |
| 单同位素质量Monoisotopic Mass | 188.105 Da |
| 拓扑极表面积Topological Polar Surface Area | 74.600 Ų |
| 重原子数Heavy Atom Count | 13 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 147.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| WGK Germany | 1 |
| RTECS | CM1980000 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| 1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492). [PMID:34879292] [10.1016/j.actbio.2021.11.042] |
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