| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A420924-1ml |
1ml |
现货  |
|
| 别名 | (4-氨基-1-羟基-1-膦酸基-丁基)-磷酸钠盐三水合物 | 4-氨基-1-羟基-1-膦酸丁酯,单钠, MK-217 | 阿屈膦酸盐 钠 三水合物 |
|---|---|
| 英文别名 | 121268-17-5 | Alendronate sodium trihydrate | Fosamax | Alendronate monosodium trihydrate | Alendronate sodium hydrate | Adronat | Alendros | Sodium alendronate | SODIUM ALENDRONATE TRIHYDRATE | 2UY4M2U3RA | CHEBI:2566 | Alendronic acid monosodium salt trihydrate | DTXSID7047801 |
| 规格或纯度 | 10mM in Water |
| 英文名称 | Alendronate sodium trihydrate |
| 生化机理 | 阿仑膦酸钠三水合物是一种骨吸收抑制剂；二磷酸法尼酯合成酶抑制剂（IC50 = 460 nM）；CD45 蛋白酪氨酸磷酸酶抑制剂。抑制法尼酰合成酶（IC50 = 460 nM）和异戊烯类生物合成途径。能够提高 TGF-β1 水平。在体内和体外均有活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
无臭无味。羟乙膦酸钠是一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂 （farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。 It's odorless and tasteless.Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate |
| INCHI | 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1 |
| InChi Key | DCSBSVSZJRSITC-UHFFFAOYSA-M |
| Smiles | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+] |
| Isomeric SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+] |
| 分子量 | 325.12 |
| Reaxy-Rn | 13434693 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13434693&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 分子量 | 325.120 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 8 |
| 氢键受体数Hydrogen Bond Acceptor Count | 11 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 325.03 Da |
| 单同位素质量Monoisotopic Mass | 325.03 Da |
| 拓扑极表面积Topological Polar Surface Area | 167.000 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 293.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 5 |
| 象形图 | GHS05, GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H318: 造成严重的眼睛损伤 H335: 可能引起呼吸道刺激 H361: 怀疑破坏生育力或未出生的孩子 H373: 通过长时间或反复暴露对器官造成损害 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P318: 如果暴露或担心，请就医。 P317: 寻求紧急医疗救助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | SZ6523500 |
| Merck Index | 229 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
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