| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A329432-1mg |
1mg |
现货  |
|
| 英文别名 | (2R,3S,6S,7R,8R)-8-butyl-3-[(3-formamido-2-hydroxybenzene)amido]-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate | Purothionin AII | Blastmycin | 3-Methyl-butyric acid (2R,3S,6S,7R,8R)-8-butyl-3-(3-formylamino-2-hydroxy-benzoylamino)-2,6-dimeth |
|---|---|
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Antimycin A3 |
| 来源 | Streptomycessp. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
抗霉素A3是抗霉素复合物的同系物。抗霉素A3是A1和A2的极性更强的类似物，并且是通过抑制泛醇氧化为泛醌的有效呼吸抑制剂。抗霉素A3具有广泛的生物学活性，具有抗真菌，驱虫，杀虫，抗病毒和抗肿瘤活性。 Antimycin A3 是从多种链霉菌中分离出来的抗生素，具有抗真菌活性。Antimycin A3 是有效的呼吸 (respiration) 抑制剂。Antimycin A3 抑制泛醇-细胞色素 c 氧化还原酶 (ubiquinol-cytochrome c oxidoreductase) 的电子转移活性，并阻止人类癌细胞的生长。Antimycin A3 也抑制 ATP 柠檬酸裂解酶，Ki 值为 60.1 µM。 Antimycin A3 is a homologue of the antimycin complex. Antimycin A3 is a more polar analogue of A1 and A2 and is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. |
| 纯度 | ≥98% |
| pKa值 | pKₐ: 7.28 (Predicted), pKₐ: 1.29 (Predicted) |
|---|---|
| Ki Data | Apoptosis regulator Bcl-2: Ki= 124 μM (human); Apoptosis regulator Bcl-W: Ki= 127 μM (human); Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl-XL protein: Ki= 127 μM (human) |
| IC50 | Apoptosis regulator Bcl-2: IC₅₀= 2 μM (human) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 208-335-6 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | [(2R,3S,6S,7R,8R)-8-butyl-3-[(3-formamido-2-hydroxybenzoyl)amino]-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate |
| INCHI | 1S/C26H36N2O9/c1-6-7-9-18-23(37-20(30)12-14(2)3)16(5)36-26(34)21(15(4)35-25(18)33)28-24(32)17-10-8-11-19(22(17)31)27-13-29/h8,10-11,13-16,18,21,23,31H,6-7,9,12H2,1-5H3,(H,27,29)(H,28,32)/t15-,16+,18-,21+,23+/m1/s1 |
| InChi Key | PVEVXUMVNWSNIG-PDPGNHKXSA-N |
| Smiles | CCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C |
| Isomeric SMILES | CCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C |
| 分子量 | 520.57 |
| Reaxy-Rn | 1277644 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1277644&ln= |
| 溶解性 | Soluble in ethanol, methanol, DMF, DMSO, and water (poorly). |
|---|---|
| 密度 | ~1.3 g/cm3(Predicted) |
| 折光率 | n20D1.55 (Predicted) |
| 沸点 | ~745.5° C at 760 mmHg (Predicted) |
| 熔点 | 170° C |
| 分子量 | 520.600 g/mol |
| XLogP3 | 4.200 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 9 |
| 可旋转键计数Rotatable Bond Count | 10 |
| 精确质量Exact Mass | 520.242 Da |
| 单同位素质量Monoisotopic Mass | 520.242 Da |
| 拓扑极表面积Topological Polar Surface Area | 157.000 Ų |
| 重原子数Heavy Atom Count | 37 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 818.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 |
|---|---|
| RTECS | NY1502900 |
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