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阿托品, 肌卡因乙酰胆碱受体 M2 拮抗剂

强效，竞争性，非选择性mAChR拮抗剂
11篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
A135946-250mg
 250mg 现货 Stock Image
A135946-1g
 1g 现货 Stock Image
A135946-5g
 5g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Class A GPCR (8201) Endogenous Metabolite (978) Glycine Receptor (All subtypes) Antagonist (3) Glycine Receptor (All subtypes) Subunit-specific (18) GPCR/G Protein (3179) M1 receptor Antagonist (46) M2 receptor Antagonist (49) M3 receptor Antagonist (42) M4 receptor Antagonist (45) M5 receptor Antagonist (35) mAChR (183) Metabolic Enzyme/Protease (4889) α2A-adrenoceptor Antagonist (19) 代谢物 (8911) 神经元信号传导 (3320)
main product photo

基本描述

别名 莨菪碱 | 阿托品
英文别名 (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate | alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester | Atropine, >=95.0% (NT) | InChI=1/C11H8Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15
规格或纯度 Moligand™, ≥99%
英文名称 Atropine
生化机理 位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。强效，竞争性，非选择性mAChR拮抗剂（IC 50 = 2.5 nM）。引起瞳孔散大。在体内显示抗毒蕈碱和抗胆碱能作用。口服具有活性
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
作用类型 拮抗剂
作用机制 肌卡因乙酰胆碱受体 M2 拮抗剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery.
纯度 ≥99%

产品属性

ALogP 1.8

关联靶点（人）

CHRM5 Tclin 毒蕈碱乙酰胆碱受体 M5(Muscarinic acetylcholine receptor M5) (9 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM3 Tclin 毒蕈碱乙酰胆碱受体 M3(Muscarinic acetylcholine receptor M3) (6 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM4 Tclin 毒蕈碱乙酰胆碱受体 M4(Muscarinic acetylcholine receptor M4) (8 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM2 Tclin 毒蕈碱乙酰胆碱受体 M2(Muscarinic acetylcholine receptor M2) (21 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM1 Tclin 毒蕈碱乙酰胆碱受体 M1(Muscarinic acetylcholine receptor M1) (10 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ADRA2A Tclin α-2A 肾上腺素受体(Alpha-2A adrenergic receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

PubChem SID 504757676
EC号 200-104-8
分子类型 小分子
IIUPAC Name [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
INCHI 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChi Key RKUNBYITZUJHSG-PJPHBNEVSA-N
Smiles CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Isomeric SMILES CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
分子量 289.37
Beilstein号 91260
Reaxy-Rn 91256
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=91256&ln=

化学和物理性质

溶解性 Soluble in dilute aqueous acid, ethanol.
敏感性 对光线和空气敏感
分子量 289.400 g/mol
XLogP3 1.800
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 289.168 Da
单同位素质量Monoisotopic Mass 289.168 Da
拓扑极表面积Topological Polar Surface Area 49.800 Ų
重原子数Heavy Atom Count 21
形式电荷Formal Charge 0
复杂度Complexity 353.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06
信号词 危险
WGK Germany 3
RTECS CK0700000
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到11个结果

批号(Lot Number) 证书类型 货号
L2307240 分析证书 A135946
L2307242 分析证书 A135946
L2307243 分析证书 A135946
L2307231 分析证书 A135946
L2307239 分析证书 A135946
C2526028 分析证书 A135946
L2307241 分析证书 A135946
L2418092 分析证书 A135946
K2301123 分析证书 A135946
K2301125 分析证书 A135946
K2301136 分析证书 A135946

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此产品的引用文献

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引用文献

1. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.  (2018)  Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro..  Invest Ophthalmol Vis Sci,  59  (7): (2778-2791).  [PMID:29860464]
2. Radzicki D et al..  (2017)  Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain..  J Neurosci,  37  (9): (2292-2304).  [PMID:28137966]
3. Huang H et al..  (2019)  M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model..  J Surg Res,  244  (358-367).  [PMID:31323391]
4. Wang YJ et al..  (2017)  The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain..  Anesth Analg,  124  (4): (1330-1338).  [PMID:28002166]
5. Dianfa Zhao, Jie Liu, Yunshan Zhou, Lijuan Zhang, Yuxu Zhong, Yang Yang, Baoquan Zhao, Mengru Yang, Yong’an Wang.  (2023)  Penetrating the Blood–Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH2(Fe).  ACS Applied Materials & Interfaces,  15  (10): (12631–12642).  [PMID:36867458] [10.1021/acsami.2c18929]
6. Dianfa Zhao, Jie Liu, Lijuan Zhang, Yunshan Zhou, Yuxu Zhong, Yang Yang, Chengcheng Huang, Yong’an Wang.  (2022)  Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.  INORGANIC CHEMISTRY,  61  (3): (1512–1520).  [PMID:34969248] [10.1021/acs.inorgchem.1c03227]
7. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao.  (2021)  Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor.  JOURNAL OF CHROMATOGRAPHY A,  1653  (462443).  [PMID:34365202] [10.1016/j.chroma.2021.462443]
8. Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu.  (2020)  Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia.  BRAIN RESEARCH BULLETIN,  164  (235).  [PMID:32905806] [10.1016/j.brainresbull.2020.08.027]
9. Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu.  (2020)  Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway.  MEDIATORS OF INFLAMMATION,  2020  (2929163).  [PMID:32508523] [10.1155/2020/2929163]
10. Ke Chen, Yilei Zhao, Ting Liu, Zhaohao Su, Huiliang Yu, Leanne Lai Hang Chan, Tiejun Liu, Dezhong Yao.  (2020)  Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex.  Jove-Journal of Visualized Experiments,  (156): (e60600).  [PMID:32090984] [10.3791/60600]
11. Lianfang Chen, Junjie Ou, Hongwei Wang, Zhongshan Liu, Mingliang Ye, Hanfa Zou.  (2016)  Tailor-Made Stable Zr(IV)-Based Metal–Organic Frameworks for Laser Desorption/Ionization Mass Spectrometry Analysis of Small Molecules and Simultaneous Enrichment of Phosphopeptides.  ACS Applied Materials & Interfaces,  8  (31): (20292–20300).  [PMID:27427857] [10.1021/acsami.6b06225]
12. Ji-Hong Chen, Qian Zhang, Yuanjie Yu, Kongling Li, Hong Liao, Longying Jiang, Lu Hong, Xiaohui Du, Xinghai Hu, Sifeng Chen, Sheng Yin, Qingmin Gao, Xiangdong Yin, Hesheng Luo, Jan D. Huizinga.  (2013)  Neurogenic and Myogenic Properties of Pan-Colonic Motor Patterns and Their Spatiotemporal Organization in Rats.  PLoS One,  8  (4): (e60474).  [PMID:23577116] [10.1371/journal.pone.0060474]
13. Shuo Li, Alhamdu Adamu, Yucai Ye, Fankai Gao, Rulin Mi, Guofang Xue, Zhaojun Wang.  (2024)  (+)-Borneol inhibits neuroinflammation and M1 phenotype polarization of microglia in epileptogenesis through the TLR4-NFκB signaling pathway.  Frontiers in Neuroscience,  18  [PMID:39605791] [10.3389/fnins.2024.1497102]
14. Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan.  (2025)  Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway.  iMeta,  (e70012).  [PMID:40236770] [10.1002/imt2.70012]
15. Huang Xiaomin, Wang Ting, Wang Ludan, Sun Yantao, Zhang Ziru, Zhang Yajun.  (2024)  Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products.  BMC Chemistry,  18  (1): (1-15).  [PMID:38702791] [10.1186/s13065-024-01198-z]

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