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阿卡波糖水合物, 淀粉酶 alpha 2A 抑制剂；麦芽糖酶-葡萄糖淀粉酶抑制剂

强大的α-葡萄糖苷酶抑制剂
167篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
A129816-250mg
 250mg 现货 Stock Image
A129816-1g
 1g 现货 Stock Image
A129816-5g
 5g 现货 Stock Image
A129816-10g
 10g 现货 Stock Image
A129816-25g
 25g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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amylase alpha 2A Inhibitor (1) Glucose Metabolism (3713) Glucosidase (71) maltase-glucoamylase Inhibitor (2) Metabolic Enzyme/Protease (4889)
main product photo

基本描述

别名 阿卡波糖 | 4",6"-二脱氧-4"-([1S]-[1,4,6/5]-4,5,6-三羟基-3-羟甲基-2-环己烯基氨基)-麦芽三糖
英文别名 Bay-g 5421 | BAY g 5421 | Bay g 5421 | BRD-A16444946-001-07-1 | MLS001424056 | AB00639959-06 | HMS2093I22 | MFCD00869592 | Prandase; | SR-01000759407 | SBI-0206777.P001 | acarbose | MD-0230 | SR-01000759407-4 | Acarbose; O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,
规格或纯度 Moligand™, ≥98%
英文名称 Acarbose Hydrate
生化机理 强大的α-葡萄糖苷酶抑制剂（IC 50 = 11 nM）。口服具有活性抗糖尿病。
应用 An α-glucosidase inhibitor
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 淀粉酶 alpha 2A 抑制剂；麦芽糖酶-葡萄糖淀粉酶抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

应用：

阿卡波糖是一种衍生的麦芽三糖抗糖尿病药，是一种可逆的α-葡萄糖苷酶抑制剂，用于医学研究以控制II型糖尿病的作用。阿卡波糖通常被用作比较其他α-葡萄糖苷酶抑制剂的参考。

Acarbose, also known as BAY g 5421, is an α-glucosidase inhibitor that prevents absorption of sucrose and maltose. This compound has been found to delay digestion of complex disaccharides and carbohydrates. Further studies suggest that this compound can stimulate phosphorylase kinase (PhK) by binding to the glucoamylase-like domain new the amino termini and causing an alteration in the structure.
An α-glucosidase inhibitor


Application：

Acarbose, a derivitized maltotriose antidiabetic drug, is a reversible α-glucosidase inhibitor used in medical studies to control the effects of Type II diabetes. Acarbose is often used as a reference to which other α-glucosidase inhibitors are compared.
纯度 ≥98%

关联靶点（人）

MGAM Tclin 麦芽糖酶-葡糖淀粉酶，肠道(Maltase-glucoamylase, intestinal) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
AMY2A Tclin 胰腺α-淀粉酶(Pancreatic alpha-amylase) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

PubChem SID 488183332
EC号 260-030-7
分子类型 未知
IIUPAC Name (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol
INCHI 1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
InChi Key XUFXOAAUWZOOIT-UGEKTDRHSA-N
Smiles CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO
Isomeric SMILES C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H](OC([C@@H]([C@H]3O)O)O)CO)CO)O)O)N[C@H]4C=C([C@H]([C@@H]([C@H]4O)O)O)CO
分子量 645.61(as Anhydrous)
Reaxy-Rn 24713589
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24713589&ln=

化学和物理性质

溶解性 Soluble in water (100 mM), DMSO (100 mM), and methanol.
比旋光度 176° (C=1,H2O)
分子量 645.600 g/mol
XLogP3 -8.500
氢键供体数Hydrogen Bond Donor Count 14
氢键受体数Hydrogen Bond Acceptor Count 19
可旋转键计数Rotatable Bond Count 9
精确质量Exact Mass 645.248 Da
单同位素质量Monoisotopic Mass 645.248 Da
拓扑极表面积Topological Polar Surface Area 321.000 Ų
重原子数Heavy Atom Count 44
形式电荷Formal Charge 0
复杂度Complexity 962.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 18
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害
预防措施声明

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。

P501: 将内容物/容器处理到。。。
RTECS LZ7153000
Merck Index 18

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找到34个结果

批号(Lot Number) 证书类型 货号
I2318159 分析证书 A129816
J2307076 分析证书 A129816
H2321101 分析证书 A129816
D2530086 分析证书 A129816
D2530087 分析证书 A129816
D2530095 分析证书 A129816
D2530096 分析证书 A129816
D2530085 分析证书 A129816
C2304160 分析证书 A129816
C2304157 分析证书 A129816
K2422279 分析证书 A129816
K2422280 分析证书 A129816
K2422281 分析证书 A129816
I2424121 分析证书 A129816
I2424122 分析证书 A129816
I2424123 分析证书 A129816
I2424124 分析证书 A129816
G2411232 分析证书 A129816
G2411233 分析证书 A129816
G2411238 分析证书 A129816
G2411239 分析证书 A129816
G2411242 分析证书 A129816
G2411243 分析证书 A129816
E2414008 分析证书 A129816
E2113060 分析证书 A129816
E2113057 分析证书 A129816
E2113058 分析证书 A129816
E2420045 分析证书 A129816
C2223142 分析证书 A129816
C2223149 分析证书 A129816
C2223169 分析证书 A129816
C2223127 分析证书 A129816
C2223160 分析证书 A129816
D2310198 分析证书 A129816

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引用文献

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5. Yu Zheng, Ruifen Zhang, Fei Huang, Lai-Hoong Cheng, Liangxiong Xu, Xuchao Jia.  (2023)  α-Glucosidase inhibitors derived from black soybean and their inhibitory mechanisms.  LWT-FOOD SCIENCE AND TECHNOLOGY,  189  (115502).  [10.1016/j.lwt.2023.115502]
6. Gonglin Cai, Hangmeng Dong, Shoulong Liu, Weijie Wu, Hailong Yang.  (2023)  Comparative Evaluation of the Physiochemical Properties, and Antioxidant and Hypoglycemic Activities of Dendrobium officinale Leaves Processed Using Different Drying Techniques.  Antioxidants,  12  (11): (1911).  [PMID:38001764] [10.3390/antiox12111911]
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34. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou.  (2022)  Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.  MOLECULES,  27  (5): (1457).  [PMID:35268560] [10.3390/molecules27051457]
35. Hui Wang, Xiaoli Kang, Shiwei Sun, Yichen Yin, Kun Jiang, Guodong Tang, Xinning Tang, Wei Wang.  (2022)  Discovery of pyrogallol thermal reaction products from a model process of roasting coffee beans as potent α-glucosidase inhibitors.  Food Bioscience,  46  (101583).  [10.1016/j.fbio.2022.101583]
36. De-Fu Hong, Gui-Lin Hu, Xing-Rong Peng, Xiao-Yuan Wang, Yan-Bing Wang, Abdulbaset Al-Romaima, Zhong-Rong Li, Ming-Hua Qiu.  (2022)  Unusual ent-Kaurane Diterpenes from the Coffea Cultivar S288 Coffee Beans and Molecular Docking to α-Glucosidase.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (2): (615–625).  [PMID:35005957] [10.1021/acs.jafc.1c06524]
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