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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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| A126073-1g |
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| A126073-5g |
5g |
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| A126073-25g |
25g |
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| A126073-100g |
100g |
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| A126073-500g |
500g |
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| 别名 | 阿昔洛韦 | 无环鸟苷 | 9-[(2-羟基乙氧基)甲基]鸟嘌呤 | 阿昔洛维 | 开糖环鸟苷 | 羟乙氧甲鸟嘌呤 | 无环鸟嘌呤核苷 | 无环鸟嘌呤 |
|---|---|
| 英文别名 | Cargosil | CAS-59277-89-3 | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B (EP IMPURITY) | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B [EP IMPURITY] | Maynar | acyclovir | NSC-758477 | ACYCLOVIR [USP-RS] | 1 -(t-Butyloxycarbonyl)-piperidine-2(S)-carboxyl |
| 规格或纯度 | Moligand™, ≥99% |
| 英文名称 | Aciclovir |
| 生化机理 | 阿昔洛韦是一种抗病毒化合物,可用于诱导转染有单纯疱疹病毒胸苷激酶(HSV-TK)的细胞凋亡。该化合物可通过改变白血病细胞系(如表达 p185BCR-ABL 的 OM9;22 细胞)的细胞周期,使 G0/G1 期同步,从而发挥抑制作用。无环鸟苷三磷酸通过 HSV-TK 磷酸化形成,可抑制病毒 DNA 聚合酶。阿昔洛韦还能抑制由 v-abl 或 bcr-abl 转化的成纤维细胞 NIH 3T3 的增殖。鸟苷衍生物能竞争性地抑制病毒 DNA 聚合酶。对单纯疱疹 1 和 2(EC 50 值分别为 0.04 和 0.44 μM)以及水痘-带状疱疹病毒(IC 50 = 0.22 μM)具有高度特异性。 |
| 应用 | An antiviral compound that can be used to induce apoptosis. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 人类疱疹病毒 1 DNA 聚合酶抑制剂 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
Acyclovir 是一种合成的核苷类似物,有效作用于疱疹病毒。 Aciclovir is a synthetic nucleoside analogue active against herpesviruses. |
| 纯度 | ≥99% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 488202820 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one |
| INCHI | 1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) |
| InChi Key | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| Smiles | C1=NC2=C(N1COCCO)N=C(NC2=O)N |
| Isomeric SMILES | C1=NC2=C(N1COCCO)N=C(NC2=O)N |
| 分子量 | 225.2 |
| Reaxy-Rn | 1219402 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1219402&ln= |
| 溶解性 | Soluble in water (partly), DMSO (50 mg/ml), DMF (1 mg/ml), 1eq. HCl (50 mM), and dilute alkalies. |
|---|---|
| 熔点 | 262°C |
| 分子量 | 225.200 g/mol |
| XLogP3 | -1.900 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 225.086 Da |
| 单同位素质量Monoisotopic Mass | 225.086 Da |
| 拓扑极表面积Topological Polar Surface Area | 115.000 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 308.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 2 |
|---|---|
| RTECS | UP0791400 |
| Merck Index | 146 |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 | |
| 分析证书 | A126073 |
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| 6. Ting Zhang, Ge Bai, Nan Cai, Yongqian Lei, Pengran Guo, Jingwei Xu. (2023) The carbon-doped Fe3O4 montmorillonite particle electrode for the degradation of antiviral drugs in electro-Fenton system. APPLIED CLAY SCIENCE, 243 (107056). [10.1016/j.clay.2023.107056] |
| 7. Fan-Zhi Bu, Yue-Ming Yu, Min Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2023) Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and Synergy: A Theoretical and Experimental Integration Research. CRYSTAL GROWTH & DESIGN, 23 (8): (5868–5882). [10.1021/acs.cgd.3c00489] |
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| 12. Zhihua Song, Yanqin Song, Yinghao Wang, Jinqiu Liu, Yumeng Wang, Wen Lin, Yaqi Wang, Jinhua Li, Jiping Ma, Gangqiang Yang, Lingxin Chen. (2022) Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases. TALANTA, 239 (123115). [PMID:34890940] [10.1016/j.talanta.2021.123115] |
| 13. Muning Chen, Jian Lu, Jia Gao, Chao Yu, Wendong Xing, Jiangdong Dai, Minjia Meng, Yongsheng Yan, Yilin Wu. (2022) Design of self-cleaning molecularly imprinted membrane with antibacterial ability for high-selectively separation of ribavirin. JOURNAL OF MEMBRANE SCIENCE, 642 (119994). [10.1016/j.memsci.2021.119994] |
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| 15. Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu. (2021) A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 608 (121082). [PMID:34506925] [10.1016/j.ijpharm.2021.121082] |
| 16. Binge Deng, Xia Luo, Meng Zhang, Liming Ye, Yu Chen. (2019) Quantitative detection of acyclovir by surface enhanced Raman spectroscopy using a portable Raman spectrometer coupled with multivariate data analysis. COLLOIDS AND SURFACES B-BIOINTERFACES, 173 (286). [PMID:30308453] [10.1016/j.colsurfb.2018.09.058] |
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| 18. Yu-Feng Shen, Lei Liu, Wei-Chao Chen, Yang Hu, Bin Zhu, Gao-Xue Wang. (2018) Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus. AQUACULTURE, 483 (252). [PMID:32287458] [10.1016/j.aquaculture.2017.09.001] |
| 19. Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang. (2017) Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). Pharmacological Reports, 69 (1254). [PMID:29128807] [10.1016/j.pharep.2017.06.012] |
| 20. Tianwei Lv, Hongyuan Yan, Jiankun Cao, Shiru Liang. (2015) Hydrophilic Molecularly Imprinted Resorcinol–Formaldehyde–Melamine Resin Prepared in Water with Excellent Molecular Recognition in Aqueous Matrices. ANALYTICAL CHEMISTRY, 87 (21): (11084–11091). [PMID:26441379] [10.1021/acs.analchem.5b03253] |
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