| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A119706-5mg |
5mg |
现货  |
|
| 英文别名 | CHEBI:131170 | CHEBI:48432 | HB3488 | HY-13948 | ty-10721 | Angiotensin II, ile(5)- | Q27293293 | 5-L-Isoleucineangiotensin II | Angiotensin II (acetate);Ang II (acetate);DRVYIHPF (acetate) | C50H71N13O12 | Angiotensinum II | Angiotensin 2 | Angiotensin I |
|---|---|
| 规格或纯度 | Moligand™, 人血管紧张素II:1045.5 |
| 英文名称 | Human angiotension Ⅱ Relative Molecular Weight |
| 生化机理 | 血管紧缩素II是肾素-血管紧张素系统（RAS）的关键成分。它通过影响肾小管中的钠水潴留，在血管收缩、血压调节和体液平衡控制方面起关键作用。此外，血管紧缩素II刺激肾上腺中醛固酮的释放，有助于维持体液和电解质平衡的调节。血管紧缩素II也促进炎症和组织损害。它抑制自发性高血压大鼠的腺苷酸环化酶活性。血管紧缩素II也活化平滑肌细胞中的JAK2和多个激酶，包括各种细胞中的p125FAK、胞浆钙依赖性酪氨酸激酶和p60c-src 。在血管肌平滑肌细胞中，它激活ERK1/2、JNK和p38 MAP 激酶。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | AT 1 受体激动剂；AT 2 受体激动剂；K 2P3.1 通道阻断剂 |
| 产品介绍 |
标准值 扩展不确定度（k=2） 单位 人血管紧张素II 1045.5 1.2 标准值 使用注意事项 本标准物质应在-20℃冰袋或-80℃干冰保护下运输，开瓶后应当一次性使用。标准物质使用过程中应严格防止沾污。 应用 人血管紧缩素II已用于诱导小鼠纤维化，以评估损伤后成纤维细胞遗失对心脏功能的影响。它也用于诱导大鼠腹主动脉瘤（AAA）。 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid |
| INCHI | 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
| InChi Key | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| Smiles | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N |
| Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N |
| 分子量 | 1046.18 |
| Reaxy-Rn | 25124120 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25124120&ln= |
| 溶解性 | Soluble to 1 (mg/mL) in water} |
|---|---|
| 密度 | 1.43 |
| 敏感性 | 对湿度敏感 |
| 分子量 | 1046.200 g/mol |
| XLogP3 | -1.700 |
| 氢键供体数Hydrogen Bond Donor Count | 13 |
| 氢键受体数Hydrogen Bond Acceptor Count | 15 |
| 可旋转键计数Rotatable Bond Count | 29 |
| 精确质量Exact Mass | 1045.53 Da |
| 单同位素质量Monoisotopic Mass | 1045.53 Da |
| 拓扑极表面积Topological Polar Surface Area | 409.000 Ų |
| 重原子数Heavy Atom Count | 75 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1980.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 9 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| RTECS | BW2165000 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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