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虾青素, 抗氧化、抗炎和抗细胞凋亡活性

45篇引用文献 COA COA
    级别和纯度:
  • ≥98%(HPLC)
  • mixture of cis and trans
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
A114383-50mg
 50mg 现货 Stock Image
A114383-250mg
 250mg 现货 Stock Image
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Apoptosis (7108) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Glucose Metabolism (3713) Immunology/Inflammation (1938) JAK/STAT Signaling (508) Metabolic Enzyme/Protease (4889) NF-κB (756) PPAR (154) Reactive Oxygen Species (316) STAT (138) Stem Cell/Wnt (1018) Vitamin D Related/Nuclear Receptor (908) 脂质代谢 (4331)
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基本描述

别名 beta-胡萝卜素-4,4'-二酮 | (3S,3'S)-3,3'-二羟基-β,β-胡萝卜素-4,4'-二酮 | 3,3'-二羟基-β,β-胡萝卜素-4,4'-二酮 | (6S,6'S)-3,3'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-四甲基十八碳-1,3,5,7,9,11,13,15,17-壬烯-1,18-二基]双(6-羟基-2,4,4-三甲基环己-2-烯-1-酮)
英文别名 DTXSID00893777 | Natupink | UNII-8XPW32PR7I | .beta.-Carotene-4,4'-dione, 3,3'-dihydroxy-, all-trans- | BCP05821 | CHEBI:40968 | LMPR01070263 | NSC-635689 | ASTAXANTHIN [WHO-DD] | 3S,3'S-Astaxanthin | Astaxanthin | SCHEMBL20047 | M01303 | trans-Astaxanthi
规格或纯度 ≥98%(HPLC), mixture of cis and trans
英文名称 Astaxanthin
生化机理 体内和体外研究提出虾青素（AST）具有促进健康的活性，表明其可用于预防多种疾病，例如癌症和帕金森病。由于其颜色鲜红，AST 已用作动物饲料中的食用色素。虾青素是一种有效的抗氧化剂，具有抗增殖、神经保护和抗炎作用。 虾青素可防止氧化应激，抑制 NF-KB，抑制促炎基因，抑制促炎化合物一氧化氮、前列腺素 E2、TNF-α 和白细胞介素-1β 的产生。 虾青素′对 TNF-α 和棕榈酸产生的氧化应激的保护作用已被证明可以改善胰岛素抵抗。 虾青素也被证明是 PPARγ 的抑制剂。
应用 虾青素是在海藻、红酵母和许多植物和动物来源中发现的?强效类胡萝卜素抗氧化剂。动物试验表明，它可降低血糖?并改善糖尿病代谢综合征的若干指标。可改善高血型模型?的血流和血管张力。体外研究表明，它上调间隙联接蛋白? 43，可用于化学防癌。 虾青素已被用于： · 作为抗氧化剂来研究其对臂尾轮虫（Brachionus manjavacas）（轮虫纲）种群生长的影响 · 研究其对糖尿病性视网膜病变治疗的影响。 · 通过人前列腺 LNCaP 细胞的表观遗传修饰，研究其在恢复 Nrf2（核因子红细胞 2 p45 相关因子 2）和谷胱甘肽 S-转移酶 P1（GSTP1）表达中的作用。
储存温度 避光,-20°C储存,充氩
运输条件 超低温冰袋运输
作用机制 抗氧化、抗炎和抗细胞凋亡活性
产品介绍

虾青素（AST）是一种红色的膳食类胡萝卜素。它主要存在于水生动物和微藻中，如雨生红球藻（Haematococcus pluvialis）和小球藻（Chlorella zofingiensis）。虾青素是在海藻、红酵母和许多植物和动物来源中发现的?强效类胡萝卜素抗氧化剂。动物试验表明，它可降低血糖?并改善糖尿病代谢综合征的若干指标。可改善高血型模型?的血流和血管张力。体外研究表明，它上调间隙联接蛋白? 43，可用于化学防癌。 虾青素已被用于： · 作为抗氧化剂来研究其对臂尾轮虫（Brachionus manjavacas）（轮虫纲）种群生长的影响 · 研究其对糖尿病性视网膜病变治疗的影响。 · 通过人前列腺 LNCaP 细胞的表观遗传修饰，研究其在恢复 Nrf2（核因子红细胞 2 p45 相关因子 2）和谷胱甘肽 S-转移酶 P1（GSTP1）表达中的作用。

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.
Astaxanthin is a potent carotenoid antioxidant found in marine algae, red yeast and many other plant and animal sources. Animal studies indicate that it reduces blood glucose and ameliorates several parameters of the diabetic metabolic syndrome. It improves blood flow and vascular tone in models of hypertension. In vitro studies indicate that it upregulates connexin 43 and thus, may be chemopreventive against cancer.
纯度 ≥98%(HPLC)

产品属性

ALogP 10.3

关联靶点（人）

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 207-451-4
分子类型 小分子
IIUPAC Name (6S)-6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxocyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethylcyclohex-2-en-1-one
INCHI 1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
InChi Key MQZIGYBFDRPAKN-UWFIBFSHSA-N
Smiles CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C
Isomeric SMILES CC1=C(C(C[C@@H](C1=O)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)/C)/C
关联CAS 7542-45-2
分子量 596.84
Reaxy-Rn 11489489
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11489489&ln=

化学和物理性质

溶解性 Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
密度 1.071
敏感性 对光线和空气敏感
熔点 215-216°C
分子量 596.800 g/mol
XLogP3 10.300
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 10
精确质量Exact Mass 596.387 Da
单同位素质量Monoisotopic Mass 596.387 Da
拓扑极表面积Topological Polar Surface Area 74.600 Ų
重原子数Heavy Atom Count 44
形式电荷Formal Charge 0
复杂度Complexity 1340.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 9
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 9
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3

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批号(Lot Number) 证书类型 货号
G2514087 分析证书 A114383
G2514088 分析证书 A114383
I2425199 分析证书 A114383
I2425202 分析证书 A114383
I2425193 分析证书 A114383
I2412114 分析证书 A114383
J2227049 分析证书 A114383
J2227089 分析证书 A114383
A2402451 分析证书 A114383
A2402453 分析证书 A114383
A2127136 分析证书 A114383

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此产品的引用文献

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引用文献

1. Lei Diao, Wenjie Liu, Yawei Xu, Bin Zhang, Lingnan Meng, Rui Yin, Huijie Chen.  (2024)  New insights into micro-algal astaxanthin's effect on deoxynivalenol-induced spleen lymphocytes pyroptosis in Cyprinus carpio: Involving mitophagy and mtROS-NF-κB-dependent NLRP3 inflammasome.  FISH & SHELLFISH IMMUNOLOGY,  144  (109259).  [PMID:38040132] [10.1016/j.fsi.2023.109259]
2. Pengjing Zhang, Yuanda Sun, Yitong Hou, Haitao Wang, Mingqian Tan.  (2024)  Fabrication of novel W/O/W emulsion gels using beeswax stabilized W/O: Preparation, characterization and co-delivery of phycocyanin and astaxanthin.  Food Bioscience,  57  (103536).  [10.1016/j.fbio.2023.103536]
3. Zi-Xu Zhang, Lu-Wei Xu, Ying-Shuang Xu, Jin Li, Wang Ma, Xiao-Man Sun, He Huang.  (2024)  Integration of genetic engineering and multi-factor fermentation optimization for co-production of carotenoid and DHA in Schizochytrium sp.  BIORESOURCE TECHNOLOGY,  394  (130250).  [PMID:38154734] [10.1016/j.biortech.2023.130250]
4. Lei Diao, Meiqi Ding, Hongzhen Sun, Yawei Xu, Rui Yin, Huijie Chen.  (2023)  Micro-algal astaxanthin ameliorates polystyrene microplastics-triggered necroptosis and inflammation by mediating mitochondrial Ca2+ homeostasis in carp’s head kidney lymphocytes (Cyprinus carpio L.).  FISH & SHELLFISH IMMUNOLOGY,  143  (109205).  [PMID:37918582] [10.1016/j.fsi.2023.109205]
5. Swagata Dutta, S.P. Jeevan Kumar, Rintu Banerjee.  (2023)  A comprehensive review on astaxanthin sources, structure, biochemistry and applications in the cosmetic industry.  Algal Research-Biomass Biofuels and Bioproducts,  74  (103168).  [10.1016/j.algal.2023.103168]
6. Dong Su, Junkui Miao, Xiaofang Liu, Xixi Wang, Yuan Yu, Kailiang Leng, Yueqin Yu.  (2023)  Separation and concentration of phospholipids and glycerides from ethanol extraction of krill by hydration and solvent partitioning.  SEPARATION AND PURIFICATION TECHNOLOGY,  317  (123900).  [10.1016/j.seppur.2023.123900]
7. Yingyuan Zhao, Zhaoxuan Wang, Shuxian Liu, Shiying Xie, Yinchun Xie, Ruifang Li, Hiroaki Oda.  (2023)  Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension.  Biomolecules,  13  (3): (496).  [PMID:36979431] [10.3390/biom13030496]
8. Xin-Nan Teng, Shu-Chang Wang, Liaqat Zeb, Yue-Sheng Dong, Zhi-Long Xiu.  (2023)  Two-Step Enzymolysis of Antarctic Krill for Simultaneous Preparation of Value-Added Oil and Enzymolysate.  Marine Drugs,  21  (1): (47).  [PMID:36662220] [10.3390/md21010047]
9. Yu Fei, Chen Jiaxin, Wei Zizhan, Zhu Pingchuan, Qing Qing, Li Bangda, Chen Huimin, Lin Weiying, Yang Hua, Qi Zhongquan, Hong Xuehui, Chen Xiao Dong.  (2022)  Preparation of carrier-free astaxanthin nanoparticles with improved antioxidant capacity.  Frontiers in Nutrition,  9  [PMID:36245512] [10.3389/fnut.2022.1022323]
10. Sun Xixi, Yuan Yujie, Chen Qitong, Nie Shiqi, Guo Jiaxuan, Ou Zutian, Huang Min, Deng Zixin, Liu Tiangang, Ma Tian.  (2022)  Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases.  Nature Communications,  13  (1): (1-12).  [PMID:36130947] [10.1038/s41467-022-33272-2]
11. Zhi-Ang Liu, Ya-Nan Zuo, Yinghui Xia, Jing Sun, Shuyun Zhu.  (2022)  Enhanced detection of ascorbic acid with cascaded fluorescence recovery of a dual-nanoquencher system.  Analytical Methods,  14  (37): (3632-3637).  [PMID:36052693] [10.1039/D2AY01019D]
12. Yan Li, Kun Hu, Chao Huang, Yong Hu, Hongwu Ji, Shucheng Liu, Jing Gao.  (2022)  Improvement of solubility, stability and antioxidant activity of carotenoids using deep eutectic solvent-based microemulsions.  COLLOIDS AND SURFACES B-BIOINTERFACES,  217  (112591).  [PMID:35679734] [10.1016/j.colsurfb.2022.112591]
13. Shi Zhihui, He Xiaoxian, Zhang Hailiang, Guo Xuena, Cheng Yanfei, Liu Xuelian, Wang Zhaoyue, He Xiuping.  (2022)  Whole Genome Sequencing and RNA-seq-Driven Discovery of New Targets That Affect Carotenoid Synthesis in Phaffia rhodozyma.  Frontiers in Microbiology,  13  [PMID:35387079] [10.3389/fmicb.2022.837894]
14. Hang-Zhi Zhu, Shan Jiang, Jun-Jie Wu, Xue-Rong Zhou, Peng-Yang Liu, Feng-Hong Huang, Xia Wan.  (2022)  Production of High Levels of 3S,3′S-Astaxanthin in Yarrowia lipolytica via Iterative Metabolic Engineering.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (8): (2673–2683).  [PMID:35191700] [10.1021/acs.jafc.1c08072]
15. Lijun Ding, Jie Yang, Kangrui Yin, Hao Cheng, Jing Li, Changhu Xue.  (2022)  The spatial arrangement of astaxanthin in bilayers greatly influenced the structural stability of DPPC liposomes.  COLLOIDS AND SURFACES B-BIOINTERFACES,  212  (112383).  [PMID:35131712] [10.1016/j.colsurfb.2022.112383]
16. Shujie Wang, Kefei Chen, Guoqin Liu.  (2022)  Monoglyceride oleogels for lipophilic bioactive delivery – Influence of self-assembled structures on stability and in vitro bioaccessibility of astaxanthin.  FOOD CHEMISTRY,  375  (131880).  [PMID:34952389] [10.1016/j.foodchem.2021.131880]
17. Zhipeng Qi, Xianyu Fan, Chunyi Zhu, Dongsheng Chang, Jianjun Pei, Linguo Zhao.  (2021)  Overexpression and Characterization of a Novel Plant Carotenoid Cleavage Dioxygenase 1 from Morus notabilis.  CHEMISTRY & BIODIVERSITY,  19  (2): (e202100735).  [PMID:34821468] [10.1002/cbdv.202100735]
18. Ru Song, Yu Qi, Zhe Jia, Xinyan Liu, Rongbian Wei.  (2020)  Astaxanthin-loaded zein/calcium alginate composite microparticles: Characterization, molecular interaction and release kinetics in fatty food simulant system.  LWT-FOOD SCIENCE AND TECHNOLOGY,  134  (110146).  [10.1016/j.lwt.2020.110146]
19. Jianfeng Mei, Xiaoyun Zhao, Yu Yi, Yanlu Zhang, Xudong Wang, Guoqing Ying.  (2020)  Preparation of astaxanthin by lipase-catalyzed hydrolysis from its esters in a slug-flow microchannel reactor.  PROCESS BIOCHEMISTRY,  98  (241).  [10.1016/j.procbio.2020.06.017]
20. Xujian Qiu, Yumeng Wu, Shengjun Chen, Lechang Sun, Guangming Liu, Hong Lin.  (2020)  Oxidative Stability and Browning Development of Semi-dried Shrimp (Acetes chinensis) with Different Salt Contents and Packaging Methods Stored at Refrigerated Temperature.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,  [10.3136/fstr.26.239]
21. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Feiyang Chen, He Zhang.  (2019)  Biocompatible protic ionic liquids-based microwave-assisted liquid-solid extraction of astaxanthin from Haematococcus pluvialis.  INDUSTRIAL CROPS AND PRODUCTS,  141  (111809).  [10.1016/j.indcrop.2019.111809]
22. Yanbin Wang, Yao Liu, Yuchen Li, Binbing Liu, Pei Wu, Shancai Xu, Huaizhang Shi.  (2019)  Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.  ACTA HISTOCHEMICA,  121  (56).  [PMID:30392635] [10.1016/j.acthis.2018.10.014]
23. Zhi-Wei Liu, Xin-An Zeng, Jun-Hu Cheng, De-Bao Liu, Rana Muhammad Aadil.  (2018)  The efficiency and comparison of novel techniques for cell wall disruption in astaxanthin extraction from Haematococcus pluvialis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  53  (9): (2212-2219).  [10.1111/ijfs.13810]
24. Dan Xie, Hongyan Mu, Tianpei Tang, Xiaosan Wang, Wei Wei, Jun Jin, Xingguo Wang, Qingzhe Jin.  (2018)  Production of three types of krill oils from krill meal by a three-step solvent extraction procedure.  FOOD CHEMISTRY,  248  (279).  [PMID:29329855] [10.1016/j.foodchem.2017.12.068]
25. Tian Ma, Yuanjie Zhou, Xiaowei Li, Fayin Zhu, Yongbo Cheng, Yi Liu, Zixin Deng, Tiangang Liu.  (2015)  Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in Escherichia coli.  Biotechnology Journal,  11  (2): (228-237).  [PMID:26580858] [10.1002/biot.201400827]
26. Jingwen Han, Jiamin Ye, Jiacheng Shi, Yueyue Fan, Xue Yuan, Ruiyan Li, Gaoli Niu, Muhammad Abubakar, Yong Kang, Xiaoyuan Ji.  (2024)  A Programmable Oral Nanomotor Microcapsule for the Treatment of Inflammatory Bowel Disease.  ADVANCED FUNCTIONAL MATERIALS,  (2413261).  [10.1002/adfm.202413261]
27. Shujie Cheng, Shimin Wu.  (2024)  A shelf life prediction method for butter based on the effects of β-carotene on colour and oxidative stability.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  77  (3): (961-972).  [10.1111/1471-0307.13078]
28. Xiuping Lin, Chang-sheng Shao, Shereen M. Elsherbiny, Qing Huang.  (2024)  Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans.  PHOTOCHEMISTRY AND PHOTOBIOLOGY,  [PMID:38695248] [10.1111/php.13958]
29. Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao, Han Wang, Jianxia Zhu, Qing Huang.  (2024)  Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages.  Food & Function,  [PMID:38512055] [10.1039/D4FO00610K]
30. Shujie Cheng, Shimin Wu, Jianqiang Lan.  (2024)  Beta-carotene and astaxanthin inhibit the formation of polycyclic aromatic hydrocarbons and oxygenated polycyclic aromatic hydrocarbons in butter during heat treatment.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  [10.1111/1471-0307.13158]
31. Shujie Wang, Yuyue Qin, Yaping Liu, Guoqin Liu, Guiguang Cheng, Thanapop Soteyome.  (2024)  Controlling release of astaxanthin in β-sitosterol oleogel-based emulsions via different self-assembled mechanisms and composition of the oleogelators.  FOOD RESEARCH INTERNATIONAL,  186  (114350).  [PMID:38729698] [10.1016/j.foodres.2024.114350]
32. Na Li, Yefan Wang, Zhifeng Tan, Yunpeng Xu, Xiaoyang Liu, Yuxin Liu, Dayong Zhou, Deyang Li.  (2024)  Effect of ultra-high pressure heat-assisted technology combined with L-cysteine on the color of ready-to-eat shrimp during storage.  FOOD CHEMISTRY,  460  (140634).  [PMID:39079355] [10.1016/j.foodchem.2024.140634]
33. Xiaorong Huang, Ru Tan, Zhi Geng, Tao Zhang, Guangpeng Feng, Gang Yang, Feng Zhao, Ping Zhuang.  (2024)  Effects of Antarctic Krill Meal in Diet on Reproductive Performance and Embryo Quality of Eriocheir sinensis.  AQUACULTURE NUTRITION,  2024  (9936529).  [PMID:38328024] [10.1155/2024/9936529]
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