3-氨基丙烷磺酸, β 淀粉样蛋白 A4 蛋白稳定剂

结合可溶性淀粉样蛋白-β。抗原纤维形成。

7篇引用文献

COA

级别和纯度:

≥97%

CAS编号: 3687-18-1
分子式: C₃H₉NO₃S
分子量: 139.17
EC号: 222-977-4
MDL号: MFCD00008225
PubChem编号: 1646
PubChem SID: 488179632

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货号 (SKU)	包装规格	是否现货
A107500-1g	1g	现货
A107500-5g	5g	现货
A107500-25g	25g	现货
A107500-100g	100g	现货
A107500-500g	500g	现货

查看相关系列

β蛋白 (137) 含硫化合物 (993) 神经元信号传导 (3320) 非杂环砌块 (8221)

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基本描述

别名	3-氨基-1-丙磺酸 \| 高牛磺酸 \| 3-氨基丙烷-1-磺酸 \| 3-氨基丙烷磺酸
英文别名	Acamprosate impurity A \| KBio1_000348 \| TRAMIPROSATE [MI] \| 3-ammoniopropane-1-sulfonate \| EINECS 222-977-4 \| SCHEMBL26759 \| 3-Amino-1-propanesulfonic acid \| UNII-5K8EAX0G53 \| 5K8EAX0G53 \| GS-3103 \| MLS000028639 \| 1-Propanesulfonic acid, 3-amino- \| AI3-52
规格或纯度	≥97%
英文名称	3-Amino-1-propanesulfonic acid
应用	重要的 GABA-mimetic 药物成分，可引起类似于 γ-氨基丁酸 (GABA) 诱导的神经反应。
运输条件	常规运输
作用类型	稳定剂
作用机制	β 淀粉样蛋白 A4 蛋白稳定剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	重要的 GABA-mimetic 药物成分，可引起类似于 γ-氨基丁酸 (GABA) 诱导的神经反应。 Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).
纯度	≥97%

产品属性

ALogP	-3.8

关联靶点（人）

KCNH2 Tclin HERG (29587 活性数据)

点击查看靶蛋白信息： KCNH2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

APP Tclin Amyloid-beta A4 protein (8510 活性数据)

点击查看靶蛋白信息： APP

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)

点击查看靶蛋白信息： APEX1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)

点击查看靶蛋白信息： EHMT2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 活性数据)

点击查看靶蛋白信息： ATAD5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (222 活性数据)

点击查看靶蛋白信息： CISD1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 活性数据)

点击查看靶蛋白信息： SLC36A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Cavia porcellus (23802 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 活性数据)

点击查看靶蛋白信息： pfk

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)

点击查看靶蛋白信息： Txnrd1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Gabrp GABA-A receptor; anion channel (5731 活性数据)

点击查看靶蛋白信息： Gabrp

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Gabbr1 GABA B receptor (127 活性数据)

点击查看靶蛋白信息： Gabbr1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488179632
EC号	222-977-4
分子类型	小分子
IIUPAC Name	3-aminopropane-1-sulfonic acid
INCHI	1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
InChi Key	SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smiles	C(CN)CS(=O)(=O)O
Isomeric SMILES	C(CN)CS(=O)(=O)O
分子量	139.17
Reaxy-Rn	1753803
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1753803&ln=

化学和物理性质

密度	1.387
熔点	293°C
分子量	139.180 g/mol
XLogP3	-3.800
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	139.03 Da
单同位素质量Monoisotopic Mass	139.03 Da
拓扑极表面积Topological Polar Surface Area	88.800 Å²
重原子数Heavy Atom Count	8
形式电荷Formal Charge	0
复杂度Complexity	133.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	1
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

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批号(Lot Number)	证书类型	货号
A2203153	分析证书	A107500
A2203160	分析证书	A107500
A2203161	分析证书	A107500
I2108056	分析证书	A107500
I2108057	分析证书	A107500
I2108058	分析证书	A107500
J1731174	分析证书	A107500
D1316062	分析证书	A107500
K1520070	分析证书	A107500
B2324297	分析证书	A107500
I2227097	分析证书	A107500
I2227098	分析证书	A107500
E2311124	分析证书	A107500
D2401026	分析证书	A107500
H1809096	分析证书	A107500
H1809095	分析证书	A107500
B2314110	分析证书	A107500
E2311118	分析证书	A107500

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引用文献

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10. Pieter Glibert,Paulien Meert,Katleen Van Steendam,Filip Van Nieuwerburgh,Dieter De Coninck,Lennart Martens,Maarten Dhaenens,Dieter Deforce. (2014-12-17) Phospho-iTRAQ: assessing isobaric labels for the large-scale study of phosphopeptide stoichiometry.. Journal of proteome research, 14 ((2)): (839-849). [PMID:25510630]
11. R A Lazar,I Mandal,N K H Slater. (2015-04-05) Effect of bore fluid composition on microstructure and performance of a microporous hollow fibre membrane as a cation-exchange substrate.. Journal of chromatography. A, 1394 (148-153). [PMID:25840664]
12. Hannah C Bygd, Kiva D Forsmark, Kaitlin M Bratlie,. (2015-05-03) Altering in\xa0vivo macrophage responses with modified polymer properties.. Biomaterials, ( 187-197 ). [PMID:25934291]
13. Michaela Herrmann,Bartholomäus Danielczak,Martin Textor,Jessica Klement,Sandro Keller. (2015-05-29) Modulating bilayer mechanical properties to promote the coupled folding and insertion of an integral membrane protein.. European biophysics journal : EBJ, 44 ((7)): (503-512). [PMID:26016666]
14. Karin Ortmayr,Sébastien Dubuis,Mattia Zampieri. (2019-04-25) Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism.. Nature communications, 10 ((1)): (1841-1841). [PMID:31015463]
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16. M I Serrano,J S Serrano,I Asadi,A Fernández,M C Serrano-Martino. (2001-07-27) Role of K+ -channels in homotaurine-induced analgesia.. Fundamental & clinical pharmacology, 15 ((3)): (167-173). [PMID:11468027]
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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度