| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A107446-20mg |
20mg |
现货  |
|
| 别名 | 青蒿醚 |
|---|---|
| 英文别名 | 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane | methoxy(trimethyl)[?] | NC00430 | 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS, |
| 规格或纯度 | Moligand™, 分析标准品, ≥98% |
| 英文名称 | Artemether |
| 生化机理 | 抗疟剂。青蒿素衍生物。与铁原卟啉IX相互作用产生自由基。在体内显示镇痛和解热作用。口服具有活性 |
| 运输条件 | 常规运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
www.aladdin-reagent.com α型为黏性油，β型为无色片状结晶。 熔点：89℃ |
| 纯度 | ≥98% |
| ALogP | 3.1 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane |
| INCHI | 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 |
| InChi Key | SXYIRMFQILZOAM-HVNFFKDJSA-N |
| Smiles | CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C |
| Isomeric SMILES | C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C |
| 分子量 | 298.38 |
| Reaxy-Rn | 9350503 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9350503&ln= |
| 密度 | 1.18 |
|---|---|
| 比旋光度 | 170° (C=1,EtOH) |
| 熔点 | 86-88°C |
| 分子量 | 298.370 g/mol |
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 298.178 Da |
| 单同位素质量Monoisotopic Mass | 298.178 Da |
| 拓扑极表面积Topological Polar Surface Area | 46.200 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 429.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 8 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H242: 加热可能会引起火灾 H302: 吞食有害 |
| 预防措施声明 |
P234: 仅保存在原始容器中 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P501: 将内容物/容器处理到。。。 P301+P317: 如果被吞咽：请寻求医疗帮助。 |
| Merck Index | 815 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 J1529015 |
分析证书 | A107446 |
| 1. Shmuklarsky MJ, Klayman DL, Milhous WK, Kyle DE, Rossan RN, Ager Jr AL, Tang DB, Heiffer MH, Canfield CJ, Schuster BG. (1993) Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.. Am J Trop Med Hyg, 48 (3): (377-84). [PMID:8470775] |
| 2. (2015) All chapters. Guidelines for the Treatment of Malaria, [PMID:26020088] |
| 3. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu. (2024) Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level. DESALINATION, 572 (117124). [10.1016/j.desal.2023.117124] |
| 4. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng. (2023) Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether. MOLECULES, 28 (21): (7452). [PMID:37959871] [10.3390/molecules28217452] |
| 5. Jing Yan, Faguang Ma, Yilin Wu. (2023) Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design. Materials Today Nano, 23 (100369). [10.1016/j.mtnano.2023.100369] |
| 6. Minjia Meng, Yi Li, Hui Peng, Binrong Li, Chuanxun Zhang, Jiajia Ren, Qingluola Ren, Yan Liu, Jianming Pan. (2023) Hydrophilic imprinted MnO2 nanowires “coating” membrane with ultrahigh adsorption capacity for highly selective separation of Artemisinin/Artemether. CHEMICAL ENGINEERING JOURNAL, 466 (143020). [10.1016/j.cej.2023.143020] |
| 7. Qiong Xu, Yin-Yan Duan, Ming Pan, Qi-Wang Jin, Jian-Ping Tao, Si-Yang Huang. (2023) In Vitro Evaluation Reveals Effect and Mechanism of Artemether against Toxoplasma gondii. Metabolites, 13 (4): (476). [PMID:37110135] [10.3390/metabo13040476] |
| 8. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu. (2023) Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport. CHEMICAL ENGINEERING JOURNAL, 462 (142277). [10.1016/j.cej.2023.142277] |
| 9. Fang Lu, Fa Zhang, Jingqi Qian, Tingting Huang, Liping Chen, Yilin Huang, Baomin Wang, Liwang Cui, Suqin Guo. (2022) Preparation and application of a specific single-chain variable fragment against artemether. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 220 (115020). [PMID:36049377] [10.1016/j.jpba.2022.115020] |
| 10. Jianxin Jia, Qi Kang, Shunzhi Liu, Yabin Song, Florence Susan Wong, Yingkun Qiu, Mingyu Li. (2022) Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish. BRITISH JOURNAL OF PHARMACOLOGY, 179 (9): (1962-1977). [PMID:34871457] [10.1111/bph.15769] |
| 11. Sennan Qiao, Hansi Zhang, Fei Sun, Zhenyan Jiang. (2021) Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study. MOLECULES, 26 (18): (5698). [PMID:34577169] [10.3390/molecules26185698] |
| 12. Xuerong Dong, Xiang Zhang, Manyuan Wang, Liwei Gu, Jing Li, Muxin Gong. (2021) Heparin-decorated nanostructured lipid carriers of artemether-protoporphyrin IX-transferrin combination for therapy of malaria. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 605 (120813). [PMID:34144137] [10.1016/j.ijpharm.2021.120813] |
| 13. Mengqi Bai, Li Qiang, Minjia Meng, Binrong Li, Suao Wang, Yilin Wu, Li Chen, Jiangdong Dai, Yan Liu, Jianming Pan. (2021) Upper surface imprinted membrane prepared by magnetic guidance phase inversion method for highly efficient and selective separation of Artemisinin. CHEMICAL ENGINEERING JOURNAL, 405 (126899). [10.1016/j.cej.2020.126899] |
| 14. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu. (2020) Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design. COMPOSITES PART B-ENGINEERING, 198 (108123). [10.1016/j.compositesb.2020.108123] |
| 15. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na. (2018) Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-14). [PMID:30477536] [10.1186/s13046-018-0960-7] |
| 16. Jiaqin Wang, Yanying Zhou, Man Wang, Wentao Bi, Hongli Li, David Da Yong Chen. (2018) High-Throughput Analysis for Artemisinins with Deep Eutectic Solvents Mechanochemical Extraction and Direct Analysis in Real Time Mass Spectrometry. ANALYTICAL CHEMISTRY, 90 (5): (3109–3117). [PMID:29381342] [10.1021/acs.analchem.7b04060] |
| 17. Jie-Hua Shi, Kai-Li Zhou, Yan-Yue Lou, Dong-Qi Pan. (2018) Multi-spectroscopic and molecular modeling approaches to elucidate the binding interaction between bovine serum albumin and darunavir, a HIV protease inhibitor. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 188 (362). [PMID:28753530] [10.1016/j.saa.2017.07.040] |
| 18. Shoubing Wang, Ziran Xu. (2016) Effects of Dihydroartemisinin and Artemether on the Growth, Chlorophyll Fluorescence, and Extracellular Alkaline Phosphatase Activity of the Cyanobacterium Microcystis aeruginosa. PLoS One, 11 (10): (e0164842). [PMID:27755566] [10.1371/journal.pone.0164842] |
| 19. Yilin Wu, Xinlin Liu, Minjia Meng, Peng Lv, Ming Yan, Xiao Wei, Hongji Li, Yongsheng Yan, Chunxiang Li. (2015) Bio-inspired adhesion: Fabrication of molecularly imprinted nanocomposite membranes by developing a hybrid organic–inorganic nanoparticles composite structure. JOURNAL OF MEMBRANE SCIENCE, 490 (169). [10.1016/j.memsci.2015.04.023] |
| 20. Yilin Wu, Ming Yan, Yongsheng Yan, Xinlin Liu, Minjia Meng, Peng Lv, Jianming Pan, Pengwei Huo, Chunxiang Li. (2014) Fabrication and Evaluation of Artemisinin-Imprinted Composite Membranes by Developing a Surface Functional Monomer-Directing Prepolymerization System. LANGMUIR, 30 (49): (14789–14796). [PMID:25420213] [10.1021/la504336s] |
| 21. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |
| 22. YiLin Wu, MinJia Meng, Xinlin Liu, Chunxiang Li, Min Zhang, Yanjun Ji, Fengquan Sun, Zhihui He, YongSheng Yan. (2014) Efficient one-pot synthesis of artemisinin-imprinted membrane by direct surface-initiated AGET-ATRP. SEPARATION AND PURIFICATION TECHNOLOGY, 131 (117). [10.1016/j.seppur.2014.05.001] |
| 23. Shengli Quan, Jinhua Li, Shuxian Ding, Xingjie Zhuo, Yuanxiao Yang, Qin Li. (2025) Artemether exerts neuroprotective effect in Parkinson's disease through the PI3K/Akt/GSK-3β signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 996 (177566). [PMID:40157705] [10.1016/j.ejphar.2025.177566] |
| 24. Fang Lu, Xiqun Wu, Fa Zhang, Jiaqiang Wu, Zhaodong Yuan, Baomin Wang, Guiyu Tan, Suqin Guo. (2024) Comparison of single-chain variable fragments and monoclonal antibody against dihydroartemisinin. JOURNAL OF IMMUNOLOGICAL METHODS, 532 (113728). [PMID:39059746] [10.1016/j.jim.2024.113728] |
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