2-氨基-4-甲基吡啶, 诱导性 NOS 抑制剂

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COA

级别和纯度:

Moligand™

≥98%

CAS编号: 695-34-1
分子式: C₆H₈N₂
分子量: 108.14
Beilstein号: 107066
EC号: 211-780-9
MDL号: MFCD00006321
PubChem编号: 1533

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货号 (SKU)	包装规格	是否现货
A107214-25g	25g	现货
A107214-100g	100g	现货
A107214-250g	250g	现货
A107214-500g	500g	现货

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Immunology/Inflammation (1938) Inducible NOS Inhibitor (7) NO Synthase (134)

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基本描述

别名	2-氨基-4-皮考林
英文别名	A0402 \| BRD-K74039237-001-01-7 \| WLN: T6NJ BZ D1 \| AKOS000119085 \| FT-0661940 \| Tocris-1020 \| W-45 \| 4-methylpyridyl amine \| STK385035 \| 4M2AP \| DTXCID9024720 \| Ascensil \| DTXSID1044720 \| Methyl-4 amino-2-pyridine \| NSC-176165 \| 4-METHYLPYRIDIN-2-AMINE, 6
规格或纯度	Moligand™, ≥98%
英文名称	2-Amino-4-picoline
生化机理	2- 氨基 -4- 甲基吡啶体外抑制小鼠原始264.7细胞诱导型 no 合酶活性。
应用	A potent inhibitor of NOS2 (iNOS)
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
作用类型	抑制剂
作用机制	诱导性 NOS 抑制剂
产品介绍	2-Amino-4-methylpyridine is a potent inhibitor of NOS2 (iNOS) in vitro.A potent inhibitor of NOS2 (iNOS) Product Description： 2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes. Product Application： 2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy¬droxy¬benzoate.
纯度	≥98%

关联靶点（人）

NOS2 Tchem 一氧化氮合酶，可诱导(Nitric oxide synthase, inducible) (5 活性数据)

点击查看靶蛋白信息： NOS2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NOS1 Tchem 一氧化氮合酶，脑(Nitric oxide synthase, brain) (4 活性数据)

点击查看靶蛋白信息： NOS1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NOS3 Tchem 一氧化氮合酶，内皮(Nitric oxide synthase, endothelial) (4 活性数据)

点击查看靶蛋白信息： NOS3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NOS1 Tchem Nitric-oxide synthase, brain (1786 活性数据)

点击查看靶蛋白信息： NOS1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)

点击查看靶蛋白信息： CYP2D6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NOS3 Tchem Nitric-oxide synthase, endothelial (1452 活性数据)

点击查看靶蛋白信息： NOS3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)

点击查看靶蛋白信息： CYP2C9

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)

点击查看靶蛋白信息： KDM4E

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)

点击查看靶蛋白信息： MEN1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NOS1 Tchem Nitric oxide sythases; iNOS & nNOS (685 活性数据)

点击查看靶蛋白信息： NOS1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Nos2 Nitric oxide synthase, inducible (3573 活性数据)

点击查看靶蛋白信息： Nos2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	211-780-9
分子类型	小分子
IIUPAC Name	4-methylpyridin-2-amine
INCHI	1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
InChi Key	ORLGLBZRQYOWNA-UHFFFAOYSA-N
Smiles	CC1=CC(=NC=C1)N
Isomeric SMILES	CC1=CC(=NC=C1)N
UN Number	2811
分子量	108.14
Beilstein号	107066
Reaxy-Rn	107066
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=107066&ln=

化学和物理性质

溶解性	Soluble in water (41 mg/ml at 20 °C), lower alcohols (slightly), chloroform, ethyl acetate, and DMF.
密度	1.068
敏感性	对湿度敏感
闪点(℉)	244.4 °F
闪点(℃)	118 °C
沸点	230°C
熔点	96-101°C
分子量	108.140 g/mol
XLogP3	0.600
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	108.069 Da
单同位素质量Monoisotopic Mass	108.069 Da
拓扑极表面积Topological Polar Surface Area	38.900 Å²
重原子数Heavy Atom Count	8
形式电荷Formal Charge	0
复杂度Complexity	72.900
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS06, GHS07, GHS08
信号词	危险
危险声明	H301: 吞咽会中毒 H311: 皮肤接触有毒 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H331: 吸入会中毒 H335: 可能引起呼吸道刺激 H373: 通过长时间或反复暴露对器官造成损害
预防措施声明	P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	TJ5150000
Merck Index	466
个人防护装备	Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

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引用文献

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12. Jonita Stankevičiūtė, Justas Vaitekūnas, Vytautas Petkevičius, Renata Gasparavičiūtė, Daiva Tauraitė, Rolandas Meškys,. (2016-12-17) Oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1.. Scientific reports, ( 39129-39129 ). [PMID:27982075]
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