This is a demo store. No orders will be fulfilled.

熊果苷, 酪氨酸酶抑制剂

天然存在的对苯二酚的β-D-吡喃葡萄糖苷。竞争性酪氨酸酶抑制剂。
有货

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
A106857-250mg
250mg 现货 Stock Image

基本描述

别名 熊果素,熊果叶甙,熊果酚甙,杨梅甙
英文别名 NCGC00095599-01 | SpecPlus_000314 | CHEBI:18305 | NCGC00166076-09 | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triol | Arbutin - Uva - p-Arbutin | BSPBio_002706 | Prestwick3_001026 | SMP1_000028 | KS-5252 | MLS002207046 |
规格或纯度 分析标准品, ≥99%
英文名称 Arbutin
生化机理 天然存在的对苯二酚的β-D-吡喃葡萄糖苷。分离与熊果(Arctostaphylos)的叶子。黑色素细胞中酪氨酸酶的竞争性抑制剂。抑制黑色素的生物合成。
应用 生化研究。化妆品工业。
运输条件 常规运输
作用类型 抑制剂
作用机制 酪氨酸酶抑制剂
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍

mp : 203 °C [α]20D : -67 ° (C=4, H2O)

纯度 ≥99%

产品属性

ALogP -0.7

关联靶点(人)

TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hs68 (138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HaCaT (4069 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HMV-2 cell line (109 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS2R16 Tchem Taste receptor type 2 member 16 (102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16 (5829 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P388 (20296 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16-F10 (4610 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trichophyton mentagrophytes (4846 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16-F1 (104 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Melan-a (81 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504758742
EC号 207-850-3
分子类型 小分子
IIUPAC Name (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
INCHI 1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
InChi Key BJRNKVDFDLYUGJ-RMPHRYRLSA-N
Smiles C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O
Isomeric SMILES C1=CC(=CC=C1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
分子量 272.25
Beilstein号 89673
Reaxy-Rn 22933063
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22933063&ln=

化学和物理性质

密度 1.556
比旋光度 -65.5 ° (C=4, H2O)
熔点 198°C
分子量 272.250 g/mol
XLogP3 -0.700
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 272.09 Da
单同位素质量Monoisotopic Mass 272.09 Da
拓扑极表面积Topological Polar Surface Area 120.000 Ų
重原子数Heavy Atom Count 19
形式电荷Formal Charge 0
复杂度Complexity 279.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 5
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

WGK Germany 3
Merck Index 773
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到2个结果

批号(Lot Number) 证书类型 货号
J2227162 分析证书 A106857
G2314025 分析证书 A106857

此产品的引用文献

引用文献

1. Wang DD et al..  (2018)  Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus\xa0subtilis: synthesis, characterization, and in\xa0vitro melanogenesis\xa0inhibition activity in BL6B16 cells..  J Ginseng Res,  42  (42-49).  [PMID:29348721]
2. Jing Wu, Funa Zhang, Haixia Yu, Shimei Qi, Yu Wu, Weihua Xiao.  (2023)  Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (16): (12810).  [PMID:37628988] [10.3390/ijms241612810]
3. Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao.  (2023)  Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6′/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (20): (7689–7702).  [PMID:37167604] [10.1021/acs.jafc.3c00527]
4. Wei Wang, Lijuan Yang, Weiwei Wang, Jianyong Zhang, Ulrich H. Engelhardt, Heyuan Jiang.  (2023)  Inhibitory Activities of Samples on Tyrosinases Were Affected by Enzyme Species and Sample Addition Methods.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (7): (6013).  [PMID:37046986] [10.3390/ijms24076013]
5. Hui Jiang, Fei Wu, Xi Jiang, Yun-Feng Pu, Li-Rong Shen, Cui-Yun Wu, Hong-Jin Bai.  (2022)  Antioxidative, cytoprotective and whitening activities of fragrant pear fruits at different growth stages.  Frontiers in Nutrition,  (1020855).  [PMID:36245497] [10.3389/fnut.2022.1020855]
6. Tang Han, Du Han, Kuang Xielan, Huang Hao, Zeng Jingshu, Long Chongde, Zhu Binbin, Fu Licheng, Wang Hua, Zhang Qingjiong, Lin Shuibin, Yan Jianhua, Shen Huangxuan.  (2022)  Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway.  Frontiers in Genetics,  13  (1763).  [PMID:36051689] [10.3389/fgene.2022.922807]
7. Tingting Lin, Ben Chen, Liqun Fang, Haibo You, Chu Chu, Qingsong Shao, Shengqiang Tong.  (2022)  Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography.  JOURNAL OF CHROMATOGRAPHY A,  1680  (463422).  [PMID:36037578] [10.1016/j.chroma.2022.463422]
8. Jiaodi Li, Chenxi Wang, Xiaoling Chen, Minghui Huang, Qian Fu, Rongjie Li, Yilin Wang, Chunyan Li, Pengcheng Zhao, Yixi Xie, Junjie Fei.  (2022)  A non-enzymatic photoelectrochemical sensor based on g-C3N4@CNT heterojunction for sensitive detection of antioxidant gallic acid in food.  FOOD CHEMISTRY,  389  (133086).  [PMID:35526285] [10.1016/j.foodchem.2022.133086]
9. Luo Yiyuan, Wang Juan, Li Shuo, Wu Yue, Wang Zhirui, Chen Shaojun, Chen Hongjiang.  (2022)  Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.  BMC Complementary Medicine and Therapies,  22  (1): (1-14).  [PMID:34996448] [10.1186/s12906-021-03492-y]
10. Peijie Wu, Ling Qiao, Han Yu, Hui Ming, Chao Liu, Wenjun Wu, Baixue Li.  (2021)  Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation.  Frontiers in Cell and Developmental Biology,  (758632).  [PMID:34926449] [10.3389/fcell.2021.758632]
11. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
12. Kunkun Guo, Xin Wang, Baolin Huang, Xiaoyun Wu, Shuimei Shen, Zimin Lin, Jie Zhao, Zheng Cai.  (2021)  Comparative study on the intestinal absorption of three gastrodin analogues via the glucose transport pathway.  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,  163  (105839).  [PMID:33852971] [10.1016/j.ejps.2021.105839]
13. Haixia Xu, Xiaofeng Li, Xuan Xin, Lan Mo, Yucong Zou, Guanglei Zhao, Yigang Yu, Kebing Chen.  (2021)  Antityrosinase Mechanism and Antimelanogenic Effect of Arbutin Esters Synthesis Catalyzed by Whole-Cell Biocatalyst.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  69  (14): (4243–4252).  [PMID:33821640] [10.1021/acs.jafc.0c07379]
14. Hao Huang, Tarun Belwal, Xingyu Lin, Jarukitt Limwachiranon, Ligen Zou, Zisheng Luo.  (2021)  Novel bind-then-release model based on fluorescence spectroscopy analysis with molecular docking simulation: New insights to zero-order release of arbutin and coumaric acid.  FOOD HYDROCOLLOIDS,  112  (106356).  [10.1016/j.foodhyd.2020.106356]
15. Saipeng Huang, Wenshuai Li, Xin Zhou, Mengyao Xie, Qing Luo, Huiyun Wen, Yane Luo, Weiming Xue.  (2020)  One-step synthesis of levodopa functionalized carbon quantum dots for selective detection of tyrosinase and inhibitor screening.  MICROCHEMICAL JOURNAL,  159  (105456).  [10.1016/j.microc.2020.105456]
16. Hao Huang, Tarun Belwal, Halah Aalim, Li Li, Xingyu Lin, Songbai Liu, Caixia Ma, Qunhe Li, Ying Zou, Zisheng Luo.  (2019)  Protein-polysaccharide complex coated W/O/W emulsion as secondary microcapsule for hydrophilic arbutin and hydrophobic coumaric acid.  FOOD CHEMISTRY,  300  (125171).  [PMID:31330369] [10.1016/j.foodchem.2019.125171]
17. Hui Chen, Wei Song, Kun-Kun Sun, He-Wei Du, Shu-Dong Wei.  (2018)  Structure Elucidation and Evaluation of Antioxidant and Tyrosinase Inhibitory Effect and Mechanism of Proanthocyanidins from Leaf and Fruit of Leucaena Leucocephala.  JOURNAL OF WOOD CHEMISTRY AND TECHNOLOGY,  [10.1080/02773813.2018.1533975]
18. Ge Zhang, Xiu-Han Guo, Shi-Sheng Wang, Yue-Qing Li, Guang-Zhe Li, Wei-Jie Zhao.  (2017)  Screening and identification of natural ligands of tyrosinase from Pueraria lobata Ohwi by a combination of ultrafiltration and LC-MS.  Analytical Methods,  (33): (4858-4862).  [10.1039/C7AY00851A]
19. Yi Tao, Dandan Su, Yingshan Du, Weidong Li, Baochang Cai, Liuqing Di, Liyun Shi, Lihong Hu.  (2016)  Magnetic solid-phase extraction coupled with HPLC-Q-TOF-MS for rapid analysis of tyrosinase binders from San-Bai decoction by Box–Behnken statistical design.  RSC Advances,  (111): (109730-109741).  [10.1039/C6RA22045B]
20. Jianmin Chen, Xiaojing Yu, Yufeng Huang.  (2016)  Inhibitory mechanisms of glabridin on tyrosinase.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  168  (111).  [PMID:27288962] [10.1016/j.saa.2016.06.008]
21. Li Zhu, Hai-Long Wu, Li-Xia Xie, Huan Fang, Shou-Xia Xiang, Yong Hu, Zhi Liu, Tong Wang, Ru-Qin Yu.  (2016)  A chemometrics-assisted excitation–emission matrix fluorescence method for simultaneous determination of arbutin and hydroquinone in cosmetic products.  Analytical Methods,  (24): (4941-4948).  [10.1039/C6AY00821F]
22. Ji Wenhua, Zhang Mingming, Gao Qianshan, Cui Li, Chen Lizong, Wang Xiao.  (2016)  Preparation of hydrophilic molecularly imprinted polymers via bulk polymerization combined with hydrolysis of ester groups for selective recognition of iridoid glycosides.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  408  (19): (5319-5328).  [PMID:27209589] [10.1007/s00216-016-9625-6]
23. Lujing Chai, Jin Zhou, Hui Feng, Cong Tang, Yuanyuan Huang, Zhaosheng Qian.  (2015)  Functionalized Carbon Quantum Dots with Dopamine for Tyrosinase Activity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation.  ACS Applied Materials & Interfaces,  (42): (23564–23574).  [PMID:26440479] [10.1021/acsami.5b06711]
24. Ting Liu, Zhentao Cheng, Derong Song, Erpeng Zhu, Hui Li, Rutao Lin, Zhiling Wan, Shunxing Liu, Zeguang Gong, Chunlan Shan.  (2024)  Arbutin alleviates Mycoplasma gallinarum-induced damage caused by pulmonary fibrosis via the JAK2/STAT3 pathway.  POULTRY SCIENCE,  (104434).  [PMID:39467406] [10.1016/j.psj.2024.104434]
25. Ying Xu, Tingting Zhang, Shimei Mu, Yanqun Peng, Duanpu Wu, Li Yang, Qing Li, Zengxue Wu, Jian Zhang.  (2025)  Discovery of Arbutin as Novel Potential Antiviral Agent Against Tomato Yellow Leaf Curl Virus.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  73  (7): (3967-3976).  [PMID:39918282] [10.1021/acs.jafc.4c11365]
26. Jian Ouyang, Na Hu, Honglun Wang.  (2024)  Petanin Potentiated JNK Phosphorylation to Negatively Regulate the ERK/CREB/MITF Signaling Pathway for Anti-Melanogenesis in Zebrafish.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  25  (11): (5939).  [PMID:38892131] [10.3390/ijms25115939]

溶液计算器