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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A105482-250mg |
250mg |
现货 ![]() |
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| A105482-1g |
1g |
现货 ![]() |
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| A105482-5g |
5g |
现货 ![]() |
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| A105482-25g |
25g |
现货 ![]() |
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| A105482-100g |
100g |
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| 英文别名 | Amfotericina B [INN-Spanish] | BRN 0078342 | EINECS 215-742-2 | MFCD00877763 | Amphotericin B liposome | C06573 | AMPH-B | AMPHOTERACIN B | AMPHOTERICIN B [JAN] | Mysteclin-F | Q412223 | s1636 | 1397-89-3, C47H73NO17 | Amphotericin B, Streptomyces nodosus |
|---|---|
| 规格或纯度 | ≥80%, 750 μg/mg |
| 英文名称 | Amphotericin B |
| 生化机理 | 抗霉菌多烯。通过靶向固醇(如麦角固醇)破坏真菌细胞膜的通透性。体内具有活性 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
溶于DMSO,水中溶解度:<0.1 g/100 mL ,21°C 本品与真菌细胞膜上的甾醇结合,损伤膜的通透性,导致菌细胞内钾离子、核苷酸、氨基酸等外漏,破坏正常代谢而起抑菌作用。 |
| 纯度 | ≥80% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 231-791-2 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid |
| INCHI | 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1 |
| InChi Key | APKFDSVGJQXUKY-INPOYWNPSA-N |
| Smiles | CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O |
| Isomeric SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
| 分子量 | 924.08 |
| Beilstein号 | 78342 |
| Reaxy-Rn | 31131291 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31131291&ln= |
| 溶解性 | Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF |
|---|---|
| 敏感性 | 对光和湿度敏感 |
| 熔点 | >170°C |
| 分子量 | 924.100 g/mol |
| XLogP3 | 0.000 |
| 氢键供体数Hydrogen Bond Donor Count | 12 |
| 氢键受体数Hydrogen Bond Acceptor Count | 18 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 923.488 Da |
| 单同位素质量Monoisotopic Mass | 923.488 Da |
| 拓扑极表面积Topological Polar Surface Area | 320.000 Ų |
| 重原子数Heavy Atom Count | 65 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1670.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 19 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 7 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 7 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 个人防护装备 | Eyeshields,Gloves,half-mask respirator (EU),half-mask respirator (US),multi-purpose combination respirator cartridge (US) |
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