计算溶液所需的质量、体积或浓度。
This is a demo store. No orders will be fulfilled.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A104375-500ml |
500ml |
现货 ![]() |
|
| 别名 | 月桂氮酮,吖酮,月桂氮卓酮 |
|---|---|
| 英文别名 | AXTGDCSMTYGJND-UHFFFAOYSA-N | BCP10858 | Q27252353 | HSDB 7660 | Laurocapram [USAN:INN] | SR-01000944876 | Laurocapram (water soluble) | N-n-dodecylcaprolactam | FT-0627723 | 1-dodecylazacycloheptane-2-one | Azone | 2H-AZEPIN-2-ONE, HEXAHYDRO-N-LAURYL- | |
| 规格或纯度 | 医药级, PharmPure™ |
| 英文名称 | Azone |
| 应用 | 氮酮是一种新型高效、安全无毒的透皮吸收促进剂,对亲水和亲油药物均有明显的透皮助渗作用。可广泛用于医药、化妆品、农药、气雾剂、印染及石油勘探等行业中,本品具有渗透作用强、无色、无味、无毒、无刺激性等优点。 |
| 运输条件 | 常规运输 |
| 产品介绍 |
几乎无臭,无味。本品在无水乙醇、醋酸乙酯、乙醚、苯及环己烷中极易溶解,在水中不溶。 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 1-dodecylazepan-2-one |
| INCHI | 1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3 |
| InChi Key | AXTGDCSMTYGJND-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCN1CCCCCC1=O |
| Isomeric SMILES | CCCCCCCCCCCCN1CCCCCC1=O |
| 分子量 | 281.48 |
| Reaxy-Rn | 167211 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=167211&ln= |
| 溶解性 | >溶解性:不溶于水,溶于乙醇、乙醚、丙酮和苯 |
|---|---|
| 密度 | 0.927 |
| 折光率 | 1.460-1.473 |
| 闪点(℃) | 165 °C |
| 沸点 | 160 °C/0.6 mmHg |
| 熔点 | -7°C(lit.) |
| 分子量 | 281.500 g/mol |
| XLogP3 | 5.900 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 11 |
| 精确质量Exact Mass | 281.272 Da |
| 单同位素质量Monoisotopic Mass | 281.272 Da |
| 拓扑极表面积Topological Polar Surface Area | 20.300 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 240.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| RTECS | CM3995000 |
| Merck Index | 5385 |
| 1. Nan Longyi, Song Haoyuan, Wang Haijun, Mi Ru, Wang Xiaoxu, Fang Liang. (2023) Design of a tulobuterol patch with improved mechanical properties: effect of transdermal permeation enhancers on the release process of metal ligand-based acrylic pressure-sensitive adhesives. Drug Delivery and Translational Research, (1-10). [PMID:38082031] [10.1007/s13346-023-01435-3] |
| 2. Yi Chen, Yongfang Wang, Shasha Song, Xiaoli Zhang, Lili Wu, Jianbing Wu, Xinyu Li. (2023) Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway. ACS Omega, 8 (43): (40260–40276). [PMID:37929119] [10.1021/acsomega.3c04281] |
| 3. Ye Liu, Jiufeng Zhao, Xingrui Mu, Junyu Deng, Xingqian Wu, Wenjie He, Yiqiu Liu, Rifang Gu, Felicity Han, Xuqiang Nie. (2024) Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, 319 (117266). [PMID:37783408] [10.1016/j.jep.2023.117266] |
| 4. Liuyu Gong, Mathias Bonmarin, Fabrizio Spano, Ya Shen, Lin Shen, Guocheng Han, Shanshan Wei, Qihan Zhang, Zhencheng Chen, Feijun Zhao. (2023) Integrated Device Based on a Sudomotor Nanomaterial for Sweat Detection. ACS Applied Materials & Interfaces, 15 (25): (29866–29875). [PMID:37318096] [10.1021/acsami.3c03401] |
| 5. Jiuheng Ruan, Chao Liu, Jiaqi Wang, Ting Zhong, Peng Quan, Liang Fang. (2022) Efficacy and safety of permeation enhancers: A kinetic evaluation approach and molecular mechanism study in the skin. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 626 (122155). [PMID:36049584] [10.1016/j.ijpharm.2022.122155] |
| 6. Yi-qiu Liu, Dandan Zhang, Junyu Deng, Ye Liu, Wei Li, Xuqiang Nie. (2022) Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers. Evidence-based Complementary and Alternative Medicine, 2022 (1419146). [PMID:35368764] [10.1155/2022/1419146] |
| 7. Ding Zhang, Boqi Chen, Qingke Mu, Wei Wang, Kaili Liang, Liyan Wang, Qing Wang. (2021) Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 166 (105975). [PMID:34391880] [10.1016/j.ejps.2021.105975] |
| 8. Ding Zhang, Wei Wang, Tao Hou, Yanjun Pang, Chao Wang, Shuai Wu, Qing Wang. (2021) New Delivery Route of Gambogic Acid Via Skin for Topical Targeted Therapy of Cutaneous Melanoma and Reduction of Systemic Toxicity. JOURNAL OF PHARMACEUTICAL SCIENCES, 110 (2167). [PMID:33373608] [10.1016/j.xphs.2020.12.024] |
| 9. Su Yanping, Lu Wenxiang, Fu Xiaoling, Xu Ying, Ye Lixiang, Yang Jian, Huang Huihui, Yu Changxi. (2020) Formulation and Pharmacokinetic Evaluation of a Drug-in-Adhesive Patch for Transdermal Delivery of Koumine. AAPS PHARMSCITECH, 21 (8): (1-11). [PMID:33099696] [10.1208/s12249-020-01793-y] |
| 10. Dong Jiang, Huajin Tan, Rujiao Zhang, Kaikang Wang, Yujia Zhang, Xiaochuan Tan, Wensheng Zheng. (2020) Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension: Preparation, characterization and in vivo study. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 591 (119864). [PMID:32991961] [10.1016/j.ijpharm.2020.119864] |
| 11. Wei Wang, Chao Liu, Zheng Luo, Xiaocao Wan, Liang Fang. (2018) Investigation of molecular mobility of pressure-sensitive-adhesive in oxybutynin patch in vitro and in vivo: Effect of sorbitan monooleate on drug release and patch mechanical property. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 122 (116). [PMID:29928984] [10.1016/j.ejps.2018.06.016] |
| 12. Ning Li, Peng Quan, XiaoCao Wan, Chao Liu, Xiaochang Liu, Liang Fang. (2017) Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 107 (138). [PMID:28693956] [10.1016/j.ejps.2017.07.006] |
| 13. Zhao Qingliang, Dai Cuixia, Fan Shanhui, Lv Jing, Nie Liming. (2016) Synergistic efficacy of salicylic acid with a penetration enhancer on human skin monitored by OCT and diffuse reflectance spectroscopy. Scientific Reports, 6 (1): (1-11). [PMID:27721398] [10.1038/srep34954] |
| 14. Mu Xingrui, Chen Jitao, Zhu Huan, Deng Junyu, Wu Xingqian, He Wenjie, Ye Penghui, Gu Rifang, Wu Youzhi, Han Felicity, Nie Xuqiang. (2025) Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling. Burns & Trauma, [PMID:40066291] [10.1093/burnst/tkaf009] |
| 15. Peng Sun, Hui Li, Kaihua Gong, Yang Zhang, Yu Cai, Chao Liu, Liang Fang. (2024) Deep eutectic solvent combined with permeation enhancer strategy to convert tandospirone from oral to transdermal formulations improving drug bioavailability. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 205 (114570). [PMID:39490429] [10.1016/j.ejpb.2024.114570] |
| 16. Yi Chen, Shasha Song, Yongfang Wang, Xiaoli Zhang, Jiafen Zhang, Lili Wu, Jianbing Wu, Xinyu Li. (2024) Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway. Arabian Journal of Chemistry, 17 (105612). [10.1016/j.arabjc.2024.105612] |
| 17. Yi Chen, Shasha Song, Yongfang Wang, Lili Wu, Jianbing Wu, Zhengmeng Jiang, Xinyu Li. (2024) Topical application of magnolol ameliorates psoriasis-like dermatitis by inhibiting NLRP3/Caspase-1 pathway and regulating tryptophan metabolism. BIOORGANIC CHEMISTRY, (108059). [PMID:39693920] [10.1016/j.bioorg.2024.108059] |