吡咯烷二硫代甲酸铵盐(APDC)

抑制NF-κB，阻止NOS mRNA的增加

20篇引用文献

COA

级别和纯度:

≥95%

CAS编号: 5108-96-3
分子式: C₅H₁₂N₂S₂
分子量: 164.29
Beilstein号: 3730472
EC号: 225-834-4
MDL号: MFCD00012720
PubChem编号: 517348

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货号 (SKU)	包装规格	是否现货
A103738-25g	25g	现货
A103738-100g	100g	现货
A103738-500g	500g	现货
A103738-2.5kg	2.5kg	现货

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NF-κB (756) 氧化应激 (50) 细胞信号转导和神经科学 (85)

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基本描述

英文别名	1-Pyrrolidinecarbodithioic acid, ammonuim salt \| AC2534 \| AKOS000121506 \| apdc \| MFCD00012720 \| NCGC00261718-01 \| SCHEMBL463334 \| Q-200528 \| Ammonium pyrrolidine-1-carbodithioate \| BCP24770 \| HMS3675D15 \| CCG-222337 \| HMS3266N09 \| P 8765 \| 1-Pyrrolidineca
规格或纯度	≥95%
英文名称	Ammonium pyrrolidinedithiocarbamate(APDC)
生化机理	这种核因子κB（NF-κB）抑制剂可防止白介素-1引起NO合酶mRNA的增加，而不会影响cAMP产生的NO合酶mRNA的形成。
应用	原子吸收分析用试剂。发射光谱测定三价铬。多种金属络合剂。测尿中痕量铅。微量测定镉、钴、铋和钼。从酸性溶液中沉淀砷、铋、镉、钴、铜、铁、锰、镍、铅、锑、锡、钒、锌。依托抑制NOS mRNA的翻译,从而防止一氧化氮合成酶(nitric oxide synthetase)的诱导;诱导大鼠血管平滑肌细胞凋亡和抑制白血病HL- 60细胞凋亡。99%规格适用于此类研究。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	有氨气味。有吸湿性。在空气中不稳定，宜保存在氨气流中。微溶于乙醇。有刺激性。原子吸收分析用试剂。发射光谱测定三价铬。多种金属络合剂。测尿中痕量铅。微量测定镉、钴、铋和钼。从酸性溶液中沉淀砷、铋、镉、钴、铜、铁、锰、镍、铅、锑、锡、钒、锌。依托抑制NOS mRNA的翻译,从而防止一氧化氮合成酶(nitric oxide synthetase)的诱导;诱导大鼠血管平滑肌细胞凋亡和抑制白血病HL- 60细胞凋亡。99%规格适用于此类研究。
纯度	≥95%

名称和识别符

EC号	225-834-4
分子类型	小分子
IIUPAC Name	azanium;pyrrolidine-1-carbodithioate
INCHI	1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChi Key	MDDIUTVUBYEEEM-UHFFFAOYSA-N
Smiles	C1CCN(C1)C(=S)[S-].[NH4+]
Isomeric SMILES	C1CCN(C1)C(=S)[S-].[NH4+]
分子量	164.29
Beilstein号	3730472
Reaxy-Rn	10782484
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10782484&ln=

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): 16.43, 最高浓度(mM): 100
密度	1.264
敏感性	对空气和热敏感；对湿度敏感
熔点	149-152°C
分子量	164.300 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	164.044 Da
单同位素质量Monoisotopic Mass	164.044 Da
拓扑极表面积Topological Polar Surface Area	37.300 Å²
重原子数Heavy Atom Count	9
形式电荷Formal Charge	0
复杂度Complexity	91.100
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

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批号(Lot Number)	证书类型	货号
J2023086	分析证书	A103738
B2518025	分析证书	A103738
F2207015	分析证书	A103738
F2207021	分析证书	A103738
J2318803	分析证书	A103738
J2326132	分析证书	A103738

技术文档和文章

RNA病毒触发信号通路

Categories: 技术文章

探索主题:

NF-kB信号通路 NF-kB RNA病毒信号通路

RNA Viruses Triggered Signal Pathway

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NF-kB NF-kB signaling pathway Signaling pathway RNA virus

RNA Viruses Triggered Signal Pathway

Categories: 技术文章

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NF-kB NF-kB signaling pathway Signaling pathway RNA virus

RNA Viruses Triggered Signal Pathway

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NF-kB NF-kB signaling pathway Signaling pathway RNA virus

此产品的引用文献

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引用文献

1. Yujing He, Jing Hu, Wei Zou, Hanjiao Chen, Xiaoming Jiang, Xiandeng Hou. (2023) Chemical vapor generation of tungsten for atomic spectrometric determination: Homogeneous sensitizer and mechanism study. ANALYTICA CHIMICA ACTA, 1278 (341746). [PMID:37709475] [10.1016/j.aca.2023.341746]
2. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu. (2023) Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis. ACS Omega, [PMID:37663478] [10.1021/acsomega.3c04724]
3. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du. (2023) An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO. CHEMICAL ENGINEERING JOURNAL, 471 (144797). [10.1016/j.cej.2023.144797]
4. Haotian Zhang, Ziyun Wei, Yichen Tong, Xiuping Song, Siyue Li, Yuanfang Sun, Chun Liu, Fei Han, Jia Yu. (2023) Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage. JOURNAL OF ETHNOPHARMACOLOGY, 314 (116628). [PMID:37196817] [10.1016/j.jep.2023.116628]
5. Yafei Zhen, Tao Lin, Hanjiao Chen, Jing Hu, Xiandeng Hou. (2022) Vapor Generation of Rare-Earth Elements via Reaction with Tetrahydroborate: Chemical Identities and Mechanisms of Formation. ANALYTICAL CHEMISTRY, 94 (44): (15176–15182). [PMID:36301518] [10.1021/acs.analchem.2c01486]
6. Chao Li, Linna Duan, Mingchao Han, Hongwei He, Mengxiang Yuan, Hairong Wang. (2022) A Chelating Resin of EDTA-Type Modified Cross-Linking Polystyrene to Preconcentrate Trace Metals for Seawater Detection. Journal of Analytical Methods in Chemistry, 2022 (2080600). [PMID:36275429] [10.1155/2022/2080600]
7. Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du, Hongqiang Song. (2022) Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics. Bioengineered, 13 (4): (9839-9854). [PMID:35436417] [10.1080/21655979.2022.2061288]
8. Haoyue Xue, Liyan Jia, Haijuan Jiang, Shu Qin, Yukun Yang, Junxue Wu, Xu Jing. (2022) A successive homogeneous liquid-liquid microextraction based on solidification of switchable hydrophilicity solvents and ionic liquids for the detection of pyrethroids and cadmium in drinks. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 110 (104569). [10.1016/j.jfca.2022.104569]
9. Caizhen Liang, Xiaobao Xie, Dandan Zhang, Jin Feng, Shunying Lu, Qingshan Shi. (2021) Biomass carbon dots derived from Wedelia trilobata for the direct detection of glutathione and their imaging application in living cells. Journal of Materials Chemistry B, 9 (28): (5670-5681). [PMID:34195715] [10.1039/D0TB02979C]
10. Jingli Zhang, Lingling Zhu, Hong Shi, Huizhe Zheng. (2021) Protective effects of miR‑155‑5p silencing on IFN‑γ‑induced apoptosis and inflammation in salivary gland epithelial cells. Experimental and Therapeutic Medicine, 22 (2): (1-11). [PMID:34194560] [10.3892/etm.2021.10314]
11. Jia Qinghui, Zhang Haihua, Su Yongmei, Liu Xin, Bai Jiangsong, Lang Wuying, Shi Qiumei, Feng Minshan. (2021) Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 77 (2): (283-294). [PMID:33595775] [10.1007/s13105-021-00796-y]
12. Wang Wanyue, Li Xin, Xu Ye, Guo Weikang, Yu Hui, Zhang Lu, Wang Yaoxian, Chen Xiuwei. (2021) Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB. CELLULAR ONCOLOGY, 44 (3): (557-568). [PMID:33469837] [10.1007/s13402-020-00582-w]
13. Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang. (2021) Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. BIOMATERIALS, 268 (120579). [PMID:33278683] [10.1016/j.biomaterials.2020.120579]
14. Shiwei Yang, Yihuan Song, Qingfang Ma, Heyong Cheng, Yuanchao Wang, Jinhua Liu. (2020) Quantification of ultra-trace organolead species in environmental water by inductively coupled plasma mass spectrometry with online solid-phase extraction and high performance liquid chromatographic separation. ANALYTICA CHIMICA ACTA, 1133 (30). [PMID:32993871] [10.1016/j.aca.2020.07.046]
15. Wei Zou, Chenghui Li, Jing Hu, Xiandeng Hou. (2020) Selective determination of Cr(Ⅵ) and non-chromatographic speciation analysis of inorganic chromium by chemical vapor generation-inductively coupled plasma mass spectrometry. TALANTA, 218 (121128). [PMID:32797885] [10.1016/j.talanta.2020.121128]
16. Yuxi Lu, Xuelu Gao, Chen-Tung Arthur Chen. (2019) Separation and determination of colloidal trace metals in seawater by cross-flow ultrafiltration, liquid-liquid extraction and ICP-MS. MARINE CHEMISTRY, 215 (103685). [10.1016/j.marchem.2019.103685]
17. Jinrong Lu, Xiaonan Wu, Yao Li, Wenquan Cui, Yinghua Liang. (2018) Modified silica gel surface with chelating ligand for effective mercury ions adsorption. Surfaces and Interfaces, 12 (108). [10.1016/j.surfin.2018.04.005]
18. Linlin Lu, Chongchong Feng, Jie Xu, Fengyang Wang, Haijun Yu, Zhiai Xu, Wen Zhang. (2017) Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells. BIOSENSORS & BIOELECTRONICS, 92 (101). [PMID:28193561] [10.1016/j.bios.2017.01.066]
19. Xiaojun Wang, Guoliang Xu, Peng Chen, Xueying Liu, Ye Fang, Siyu Yang, Guozhen Wang. (2016) Arsenic speciation analysis in environmental water, sediment and soil samples by magnetic ionic liquid-based air-assisted liquid–liquid microextraction. RSC Advances, 6 (111): (110247-110254). [10.1039/C6RA21199B]
20. Xiaojun Wang, Long Wu, Jiaqi Cao, Xincheng Hong, Rui Ye, Weiji Chen, Ting Yuan. (2016) Magnetic effervescent tablet-assisted ionic liquid dispersive liquid–liquid microextraction of selenium for speciation in foods and beverages. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, [PMID:27181611] [10.1080/19440049.2016.1189807]

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