基本描述

别名	1-氨基-1-环丁烷羧酸
英文别名	1-Aminocyclobutanecarboxylic acid \| 1-Amino-cyclobutanecarboxylic acid \| SY002606 \| 5-(Methylthio)-1,3,4-thiadiazole-2(3H)-thione \| BBL001782 \| CCG-39205 \| FT-0655686 \| 1-Amino-1-cyclobutanecarboxylic acid, 97% \| 1y1z \| AB00053379-03 \| Spectrum2_001476 \|
规格或纯度	≥97%
英文名称	1-Amino-1-cyclobutanecarboxylic acid
运输条件	常规运输
作用类型	激动剂
产品介绍	1-Amino-1-cyclobutanecarboxylic acid is an NMDA receptor antagonist acting at the glycine site.An NMDA receptor antagonist that acts at the glycine site 1-Amino-1-cyclobutanecarboxylic acid is an NMDA receptor antagonist acting at the glycine site. An NMDA receptor antagonist that acts at the glycine site
纯度	≥97%

关联靶点（人）

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)

点击查看靶蛋白信息： CYP2D6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)

点击查看靶蛋白信息： CYP2C9

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)

点击查看靶蛋白信息： CYP2C19

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

GRIN2C Tclin Glutamate [NMDA] receptor subunit epsilon 3 (47 活性数据)

点击查看靶蛋白信息： GRIN2C

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)

点击查看靶蛋白信息： SLCO1B1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)

点击查看靶蛋白信息： SLCO1B3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)

点击查看靶蛋白信息： MEN1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

lef Anthrax lethal factor (7585 活性数据)

点击查看靶蛋白信息： lef

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 活性数据)

点击查看靶蛋白信息： Mapt

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)

点击查看靶蛋白信息： ffp

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 活性数据)

点击查看靶蛋白信息： Grin1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 活性数据)

点击查看靶蛋白信息： Slc1a5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488186558
分子类型	小分子
IIUPAC Name	1-aminocyclobutane-1-carboxylic acid
INCHI	1S/C5H9NO2/c6-5(4(7)8)2-1-3-5/h1-3,6H2,(H,7,8)
InChi Key	FVTVMQPGKVHSEY-UHFFFAOYSA-N
Smiles	C1CC(C1)(C(=O)O)N
Isomeric SMILES	C1CC(C1)(C(=O)O)N
分子量	115.13
Reaxy-Rn	2802253
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2802253&ln=

化学和物理性质

溶解性	Soluble to 100 mM in Water
密度	1.29
熔点	261°C
分子量	115.130 g/mol
XLogP3	-2.900
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	3
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	115.063 Da
单同位素质量Monoisotopic Mass	115.063 Da
拓扑极表面积Topological Polar Surface Area	63.300 Å²
重原子数Heavy Atom Count	8
形式电荷Formal Charge	0
复杂度Complexity	118.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	GU1336000
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到4个结果

批号(Lot Number)	证书类型	货号
I2409384	分析证书	A102435
B2322270	分析证书	A102435
J1809097	分析证书	A102435
J1809096	分析证书	A102435

引用文献

1. L C Washburn,T T Sun,B Byrd,R L Hayes,T A Butler. (1979-10-01) 1-aminocyclobutane[11C]carboxylic acid, a potential tumor-seeking agent.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 20 ((10)): (1055-1061). [PMID:231642]
2. R P Compton,W F Hood,J B Monahan. (1990-01-23) Evidence for a functional coupling of the NMDA and glycine recognition sites in synaptic plasma membranes.. European journal of pharmacology, 188 ((1)): (63-70). [PMID:2155123]
3. W F Hood,E T Sun,R P Compton,J B Monahan. (1989-02-28) 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor.. European journal of pharmacology, 161 ((2-3)): (281-282). [PMID:2542048]
4. K F Hübner,S Krauss,L C Washburn,W D Gibbs,E C Holloway. (1981-06-01) Tumor detection with 1-aminocyclopentane and 1-aminocyclobutane C-11-carboxylic acid using positron emission computerized tomography.. Clinical nuclear medicine, 6 ((6)): (249-252). [PMID:6971725]
5. J K Relton,P J Strijbos,A L Cooper,N J Rothwell. (1993-01-01) Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat.. Brain research bulletin, 32 ((3)): (223-226). [PMID:8374800]
6. E Gershonov,R Granoth,E Tzehoval,Y Gaoni,M Fridkin. (1996-11-22) 1-Aminocyclobutanecarboxylic acid derivatives as novel structural elements in bioactive peptides: application to tuftsin analogs.. Journal of medicinal chemistry, 39 ((24)): (4833-4843). [PMID:8941397]
7. Y Kosugi,N Oyamada,S Satoh,T Yoshioka,E Onodera,Y Yamada. (1997-03-01) Inhibition by 1-aminocyclobutane-1-carboxylate of the activity of 1-aminocyclopropane-1-carboxylate oxidase obtained from senescing petals of carnation (Dianthus caryophyllus L.) flowers.. Plant & cell physiology, 38 ((3)): (312-318). [PMID:9150604]
8. M Gatos,F Formaggio,M Crisma,C Toniolo,G M Bonora,Z Benedetti,B Di Blasio,R Iacovino,A Santini,M Saviano,J Kamphuis. (1997-03-01) Conformational characterization of the 1-aminocyclobutane-1-carboxylic acid residue in model peptides.. Journal of peptide science : an official publication of the European Peptide Society, 3 ((2)): (110-122). [PMID:9230476]
9. Atsushi Inanobe,Hiroyasu Furukawa,Eric Gouaux. (2005-07-06) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.. Neuron, 47 ((1)): (71-84). [PMID:15996549]
10. R H Porter,R S Briggs,P J Roberts. (1992-09-01) Modulation of [3H]3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex.. European journal of pharmacology, 227 ((1)): (83-88). [PMID:1426025]
11. T S Rao,J A Cler,R P Compton,M R Emmett,S Mick,E T Sun,S Iyengar,P L Wood. (1990-03-01) Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor.. Neuropharmacology, 29 ((3)): (305-309). [PMID:2158004]
12. G B Watson,T H Lanthorn. (1990-08-01) Pharmacological characteristics of cyclic homologues of glycine at the N-methyl-D-aspartate receptor-associated glycine site.. Neuropharmacology, 29 ((8)): (727-730). [PMID:2177161]
13. I Varela,M Avila,J M Mato,L Hue. (1990-04-15) Insulin-induced phospho-oligosaccharide stimulates amino acid transport in isolated rat hepatocytes.. The Biochemical journal, 267 ((2)): (541-544). [PMID:2185744]
14. G B Watson,M A Bolanowski,M P Baganoff,C L Deppeler,T H Lanthorn. (1989-08-22) Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA.. European journal of pharmacology, 167 ((2)): (291-294). [PMID:2556287]
15. V N Balaji,K Ramnarayan,M F Chan,S N Rao. (1995-05-01) Conformational studies on model peptides with 1-aminocyclobutane 1-carboxylic acid residues.. Peptide research, 8 ((3)): (178-186). [PMID:7670233]
16. Y Gaoni,A G Chapman,N Parvez,P C Pook,D E Jane,J C Watkins. (1994-12-09) Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives.. Journal of medicinal chemistry, 37 ((25)): (4288-4296). [PMID:7996540]
17. Cassandra L Kussius,Gabriela K Popescu. (2009-08-04) Kinetic basis of partial agonism at NMDA receptors.. Nature neuroscience, 12 ((9)): (1114-1120). [PMID:19648915]

溶液计算器

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
A102435-1g	1g	现货
A102435-5g	5g	现货
A102435-10g	10g	期货
A102435-25g	25g	期货

1-氨基环丁烷羧酸

库存信息

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器