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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A102397-5mg |
5mg |
现货 ![]() |
| |
| A102397-25mg |
25mg |
现货 ![]() |
| |
| A102397-100mg |
100mg |
现货 ![]() |
| |
| A102397-500mg |
500mg |
现货 ![]() |
|
| 别名 | (2R,3S,4S)-2-(4-甲氧苯基)-3,4-吡咯二醇3-乙酸酯 |
|---|---|
| 英文别名 | (-) Anisomycin | 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate | Bio1_000839 | Antibiotic PA-106 | AKOS015916532 | BDBM63919 | DivK1c_000855 | NSC 76712 | (2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl acetate | 1,4,5-Trideoxy-1,4-imi |
| 规格或纯度 | ≥97% |
| 英文名称 | Anisomycin |
| 生化机理 | 从Streptomyces griseolus 分离的抗生素,抑制蛋白质合成。通过抑制真核生物核糖体肽基转移酶的活性而发挥作用。据报道,诱导多种细胞的细胞凋亡,包括早幼粒细胞性白血病细胞,Jurkat细胞,心肌细胞和结肠腺癌细胞。启动细胞内信号和即早基因诱导。选择性信号激动剂。强效Jun-NH2末端激酶(JNK)激动剂。活化促分裂原活化蛋白(MAP)激酶(JNK/ SAPK和p38/RK)。抗原虫剂。蛋白质合成的翻译抑制剂。激酶级联的高效激活剂。有效激活应激激活的蛋白激酶,p38,JNK MAP和其他激酶。 |
| 应用 | 蛋白质合成抑制剂。引起PC12细胞的凋亡 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。有毒,请参阅SDS以获取更多信息。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
Soluble in methanol (20 mg/ml clear, faint yellow solution), ethanol (25 mg/ml), DMSO (50 mg/ml), alcohols, esters, ketones, chloroform, benzene (slightly), toluene (slightly), hexane (slightly), water (2 mg/ml), and ethyl acetate (10 mg/ml clear, colorless solution), DMF (20 mg/ml), and PBS pH 7.2 (0.5 mg/ml).蛋白质合成抑制剂。引起PC12细胞的凋亡 Soluble in methanol (20 mg/ml clear, faint yellow solution), ethanol (25 mg/ml), DMSO (50 mg/ml), alcohols, esters, ketones, chloroform, benzene (slightly), toluene (slightly), hexane (slightly), water (2 mg/ml), and ethyl acetate (10 mg/ml clear, colorless solution), DMF (20 mg/ml), and PBS pH 7.2 (0.5 mg/ml). |
| 纯度 | ≥97% |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 245-269-7 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate |
| INCHI | 1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
| InChi Key | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| Smiles | CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O |
| Isomeric SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O |
| UN Number | 3462 |
| 分子量 | 265.3 |
| Beilstein号 | 20705 |
| Reaxy-Rn | 221005 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=221005&ln= |
| 溶解性 | Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml |
|---|---|
| 密度 | 1.21 |
| 敏感性 | 对热敏感,易吸潮 |
| 比旋光度 | -30° (C=1,MeOH) |
| 熔点 | 144 °C |
| 分子量 | 265.300 g/mol |
| XLogP3 | 0.900 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 265.131 Da |
| 单同位素质量Monoisotopic Mass | 265.131 Da |
| 拓扑极表面积Topological Polar Surface Area | 67.800 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 302.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P330: 漱口 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P361+P364: 立即脱掉所有沾染的衣服,清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽:立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | BZ9800000 |
| Merck Index | 670 |
| 个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
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