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(Z)-4EGI-1 - 98%, high purity , CAS No.901787-88-0

COA

Grade & Purity:

≥98%

Cas Number: 901787-88-0
Molecular Weight: 451.28

In stock

Item Number

E650643

Grouped product items
SKU	Size	Availability	Price
E650643-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
E650643-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
E650643-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90
E650643-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,450.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity In Vitro (Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected. (Z)-4EGI-1 inhibits cancer cells proliferation with IC 50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CRL-2813 melanoma cells Concentration: 15 µM, 30 µM Incubation Time: 6 hours Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. Form:Solid IC50& Target:eIF4

Names and Identifiers

Smiles	O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
Molecular Weight	451.28

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)

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