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WZ3146 - 10mM in DMSO, high purity , CAS No.1214265-56-1(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1214265-56-1(DMSO)
Molecular Weight: 464.95

In stock

Item Number

W409245

Grouped product items
SKU	Size	Availability	Price	Qty
W409245-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$763.90

EGFR/ErbB1 Selective Inhibitors | Activators

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Compound libraries (12325)

Basic Description

Synonyms	N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information WZ3146 is a mutant-selective irreversible inhibitor ofEGFR(L858R)andEGFR(E746_A750)withIC50of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). In vitro WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells. In vivo Cell Data cell lines： Concentrations：0-10 μM Incubation Time：72 hours Powder Purity:≥99%

Names and Identifiers

Smiles	CN1CCN(CC1)C2=CC=C(NC3=NC=C(Cl)C(=N3)OC4=CC(=CC=C4)NC(=O)C=C)C=C2
Molecular Weight	464.95

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 10 mg/mL (39.01 mM);

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