Skip to the beginning of the images gallery

WAY-316606 - 99%, high purity , CAS No.915759-45-4

COA

Grade & Purity:

Moligand™

≥99%

Cas Number: 915759-45-4
Molecular Weight: 448.48
PubChem CID: 16727102
PubChem SID: 504768505

In stock

Item Number

W413340

Grouped product items
SKU	Size	Availability	Price
W413340-2mg	2mg	2	$42.90
W413340-5mg	5mg	3	$88.90
W413340-10mg	10mg	2	$142.90
W413340-25mg	25mg	2	$321.90
W413340-50mg	50mg	2	$429.90
W413340-100mg	100mg	2	$692.90
W413340-200mg	200mg	2	$1,247.90

SFRP Antagonists

View related series

sFRP-1 (1) Stem Cell/Wnt (1019)

Basic Description

Synonyms	D83680 \| A915415 \| DTXSID90587395 \| 5-(Benzenesulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzene-1-sulfonamide \| CS-0996 \| EX-A1883 \| HMS3749G03 \| AC-36231 \| BDBM50265467 \| GTPL9945 \| 5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesul
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	Information WAY-316606 WAY-316606, a specific antagonist of SFRP1 , functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb. Targets sFRP1 In vitro WAY-316606 enhances hair shaft production, hair shaft keratin expression, and inhibits spontaneous HF regression (catagen) ex vivo. WAY-316606 effectively enhances β-catenin activity in mammalian skin cell populations, namely in both human hair pre-cortex keratinocytes and DP fibroblasts ex vivo.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Trifluoromethylbenzenes Benzenesulfonyl compounds Piperidines Organosulfonamides Sulfones Aminosulfonyl compounds Dialkylamines Azacyclic compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzenesulfonamide - Trifluoromethylbenzene - Benzenesulfonyl group - Piperidine - Organosulfonic acid amide - Sulfone - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Secondary aliphatic amine - Secondary amine - Azacycle - Organoheterocyclic compound - Alkyl halide - Organic oxygen compound - Organosulfur compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Amine - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.36
HBD Count	2
Rotatable Bond	6

Associated Targets(Human)

SFRP1 Tchem Secreted frizzled-related protein 1 (1 Activities)

Discover Target: SFRP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WNT3 Tchem Proto-oncogene Wnt-3 (1 Activities)

Discover Target: WNT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SFRP1 Tchem Secreted frizzled-related protein 1 (240 Activities)

Discover Target: SFRP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

WNT3 Tchem Proto-oncogene protein Wnt-3 (144 Activities)

Discover Target: WNT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504768505
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768505
IUPAC Name	5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
INCHI	InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
InChIKey	ITBGJNVZJBVPLJ-UHFFFAOYSA-N
Smiles	C1CNCCC1NS(=O)(=O)C2=C(C=CC(=C2)S(=O)(=O)C3=CC=CC=C3)C(F)(F)F
Isomeric SMILES	C1CNCCC1NS(=O)(=O)C2=C(C=CC(=C2)S(=O)(=O)C3=CC=CC=C3)C(F)(F)F
PubChem CID	16727102
Molecular Weight	448.48

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
C2301391	Certificate of Analysis	Sep 09, 2022	W413340
C2301392	Certificate of Analysis	Sep 09, 2022	W413340
C2301393	Certificate of Analysis	Sep 09, 2022	W413340
C2301395	Certificate of Analysis	Sep 09, 2022	W413340
C2301397	Certificate of Analysis	Sep 09, 2022	W413340
C2301351	Certificate of Analysis	Sep 09, 2022	W413340
C2301394	Certificate of Analysis	Sep 09, 2022	W413340

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 90 mg/mL (200.67 mM); Ethanol: 7 mg/mL (15.6 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	90
DMSO(mM) Max Solubility	200.677845165894
Water(mg / mL) Max Solubility	1
Water(mM) Max Solubility	2.2297538351766
Molecular Weight	448.500 g/mol
XLogP3	2.700
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	448.074 Da
Monoisotopic Mass	448.074 Da
Topological Polar Surface Area	109.000 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	747.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration