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VU 0357017 Hydrochloride - ≥98% (HPLC), high purity , CAS No.1135242-13-5

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 1135242-13-5
Molecular Weight: 369.89
MDL number: MFCD17215959
PubChem CID: 25010775
PubChem SID: 488200737

In stock

Item Number

V134258

Grouped product items
SKU	Size	Availability	Price
V134258-5mg	5mg	5	$82.90
V134258-25mg	25mg	5	$373.90
V134258-50mg	50mg	5	$533.90
V134258-100mg	100mg	5	$949.90
V134258-250mg	250mg	5	$2,137.90

Positive allosteric modulator of M1receptors

View related series

Class A GPCR (4138) GPCR/G Protein (3172) mAChR (182) Neuronal Signaling (3320)

Basic Description

Synonyms	EX-A1757 \| N-ACETYL PROCAINAMIDE(<30%) \| Ethyl 4-{[2-(2-methylbenzamido)ethyl]amino}piperidine-1-carboxylate--hydrogen chloride (1/1) \| J-002978 \| VU0357017 \| 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester, monohydrochl
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Positive allosteric modulator of muscarinic M1receptors (EC50= 198 nM). Displays no activity at M2-M5at concentrations up to 30μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippoca
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia。

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Piperidinecarboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Piperidinecarboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Piperidinecarboxylic acids
Alternative Parents	o-Toluamides Benzamides Benzoyl derivatives Aminopiperidines Carbamate esters Secondary carboxylic acid amides Dialkylamines Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzamide - Benzoic acid or derivatives - Piperidinecarboxylic acid - O-toluamide - Toluamide - Benzoyl - 4-aminopiperidine - Toluene - Monocyclic benzene moiety - Benzenoid - Carbamic acid ester - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Secondary aliphatic amine - Carboxylic acid derivative - Secondary amine - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Carbonyl group - Amine - Organic oxygen compound - Hydrochloride - Organic nitrogen compound - Organic oxide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as piperidinecarboxylic acids. These are compounds containing a piperidine ring which bears a carboxylic acid group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)

Discover Target: CHRM4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)

Discover Target: CHRM5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)

Discover Target: CHRM3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488200737
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200737
IUPAC Name	ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]piperidine-1-carboxylate;hydrochloride
INCHI	InChI=1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H
InChIKey	XKJQVUIXSBOCPP-UHFFFAOYSA-N
Smiles	CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl
Isomeric SMILES	CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl
WGK Germany	2
PubChem CID	25010775
Molecular Weight	369.89

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
C2323930	Certificate of Analysis	Jan 15, 2025	V134258
C2323927	Certificate of Analysis	Jan 15, 2025	V134258
C2323914	Certificate of Analysis	Jan 15, 2025	V134258
C23231429	Certificate of Analysis	Jan 15, 2025	V134258
C2323969	Certificate of Analysis	Jan 15, 2025	V134258
C2323970	Certificate of Analysis	Jan 15, 2025	V134258
C2323971	Certificate of Analysis	Jan 15, 2025	V134258
C2323946	Certificate of Analysis	Jan 15, 2025	V134258
C2323824	Certificate of Analysis	Jan 15, 2025	V134258
C2323833	Certificate of Analysis	Jan 15, 2025	V134258

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 9.25, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 1.85, Max Conc. mM: 5
Sensitivity	Moisture sensitive
Molecular Weight	369.900 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	369.182 Da
Monoisotopic Mass	369.182 Da
Topological Polar Surface Area	70.700 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	408.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Documents & Articles

Alzheimer’s Disease Signaling

Categories: Technical articles

Tags:

inhibitor Alzheimer's disease

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