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UCM-1306 - 99%, high purity , CAS No.2258608-78-3

COA

Grade & Purity:

≥99%

Cas Number: 2258608-78-3
Molecular Weight: 279.33

In stock

Item Number

U649136

Grouped product items
SKU	Size	Availability	Price
U649136-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
U649136-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$240.90
U649136-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$490.90
U649136-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$780.90
U649136-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

View related series

Class A GPCR (4138) Dopamine Receptor (237) GPCR/G Protein (3172) Neuronal Signaling (3320)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also f
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD). In Vitro UCM-1306 (2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl; 1-10 μM) increases cAMP in a concentration-response manner with high potency (EC 50 =60 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo UCM-1306 (2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl; 5 mg/kg; p.o.; C57BL/6J mice) has good brain penetration and oral availability. Plasma concentration can be quantified for up to 8 h with T max at 0.5 h . UCM-1306 (1 mg/kg; ip) enhances cocaine-induced hyperlocomotion in adult mice . UCM-1306 (1 mg/kg; ip) helps consolidate long-term memory formation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult C57BL/6J mice with cocaine-induced hyperactivity model Dosage: 1 mg/kg; cocaine (20 mg/kg, sc) Administration: Intraperitoneal injection Result: Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R. Animal Model: Adult C57BL/6J mice Dosage: 1 mg/kg Administration: Intraperitoneal injection Result: Increased memory trace in C57BL/6J mice. Form:Solid

Names and Identifiers

Smiles	O=S(C1=CC=C(C2=C(OCF)C=CC=C2)C=C1)(C)=N
Molecular Weight	279.33

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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