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TRPV1 antagonist 3 - 99%, high purity , CAS No.T659415

COA

Grade & Purity:

≥99%

Molecular Weight: 391.53

In stock

Item Number

T659415

Grouped product items
SKU	Size	Availability	Price
T659415-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$320.90
T659415-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$520.90
T659415-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,030.90

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Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181)

Basic Description

Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC 50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant. Appearance:Solid IC50& Target:hTRPV1 2.66 nM (IC 50 ) TRPM8 7.45 μM (IC 50 ) In Vitro:TRPV1 antagonist 3 (Compound 7q) is highly selective for the TRPV1 receptor relative to other TRP channels. TRPV1 antagonist 3 shows acceptable aqueous solubility (solubility at pH 7.4 = 26 μg/mL). MCE has not independently confirmed the accurac In Vivo:TRPV1 antagonist 3 (Compound 7q) (0-30mg/kg; i.p.; 30 min) shows anti-nociceptive effect mainly mediated by blocking CAP-activated channel. TRPV1 antagonist 3 (0-100mg/kg; i.g.) had no obvious thermal effect in rats. TRPV1 antagonist 3 (10 mg/ Biological Activity:TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC 50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant.

Names and Identifiers

Smiles	CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C
Molecular Weight	391.53

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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