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Trastuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

1 Citations COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
T411999
Grouped product items
SKU Size
Availability
 Price Qty
T411999-100μg
100μg
10
$37.90
T411999-1mg
1mg
4
$159.90
T411999-5mg
5mg
1
$664.90
T411999-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,196.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: ERBB2
Accession#:P04626 (13) ADC Antibody (3) Antibody-drug Conjugate/ADC Related (553) EGFR (254) erb-b2 receptor tyrosine kinase 2 Antibody (4) ERBB2 (13) Gene ID:2064 (13) HER2 (11) JAK/STAT Signaling (507) m-PEG (327) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Product Name Trastuzumab (anti-HER2) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ERBB2/HER2/CD340, >95%, high purity, Human IgG1, Antibody of erb-b2 receptor tyrosine kinase 2
Synonyms 8-Aminoguanosine, >=98% (HPLC) | SHO2CA1BRO | Guanosine, 8-amino- | SCHEMBL483333 | 2,8-diamino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one | PD183255 | NSC 90390 | NSC816045 | NSC-816045 | NSC-90390 | BDBM50227263
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a
Host species Human
Specificity ERBB2/HER2/CD340
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of erb-b2 receptor tyrosine kinase 2
Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
CAS 180288-69-1
Concentration See COA
Product Description

Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Nucleosides, nucleotides, and analogues
Class Purine nucleosides
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Purine nucleosides
Alternative Parents Glycosylamines  6-oxopurines  Pentoses  Hypoxanthines  Pyrimidones  Aminopyrimidines and derivatives  Aminoimidazoles  N-substituted imidazoles  Vinylogous amides  Tetrahydrofurans  Heteroaromatic compounds  Secondary alcohols  Oxacyclic compounds  Azacyclic compounds  Hydrocarbon derivatives  Organic oxides  Organopnictogen compounds  Primary alcohols  Primary amines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Pentose monosaccharide - Hypoxanthine - Purinone - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidone - Aminoimidazole - N-substituted imidazole - Monosaccharide - Pyrimidine - Azole - Tetrahydrofuran - Vinylogous amide - Imidazole - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Primary amine - Amine - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
External Descriptors Not available

Associated Targets(Human)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor (487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin FASN/HER2 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Storage and Shipping

Shape Liquid
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 2-8℃ short term (1-2 weeks). Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Trastuzumab (anti-HER2) (T411999) - SEC
The purity of Trastuzumab (anti-HER2) (T411999) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
ZJ25F0319113 Certificate of Analysis Mar 12, 2025 T411999
ZJ24F0202898 Certificate of Analysis Mar 01, 2024 T411999
ZJ24F0202897 Certificate of Analysis Mar 01, 2024 T411999
ZJ24F0202896 Certificate of Analysis Mar 01, 2024 T411999

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