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TML-6 - 99%, high purity , CAS No.1462868-88-7

COA

Grade & Purity:

≥99%

Cas Number: 1462868-88-7
Molecular Weight: 523.62
PubChem CID: 72705569

In stock

Item Number

T646596

Grouped product items
SKU	Size	Availability	Price	Qty
T646596-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
T646596-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90

View related series

Amyloid-β (136) Keap1-Nrf2 (107) mTOR (145) Neuronal Signaling (3320) NF-κB (747) PI3K/Akt/mTOR (765)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR , and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the pote
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR , and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research In Vitro TML-6 (0.65-5.24 µg/mL; for 24 h) reduces the protein expression levels of APP and phospho-NF-κB, and induces the protein expression level of ApoE. TML-6 inhibits the mTOR signaling pathway through the suppression of phospho-mTOR. TML-6 (0.31, 0.63, 2.5, 5, 10, 20 μM; 24 h) reveals no cytotoxicity in Huh-7 cells at concentrations below 5 μM and has an IC 50 of 4.19 µg/mL (8 μM). TML-6 (1.05, 2.09, 3.14, 4.19 μg/mL; 24 h) reduces the production of Aβ40 and Aβ42 between 1.05, 2.09 and 3.14 μg/mL (equal to 2, 4 and 6 μM) in a dose-dependent manner in N2a/APPswe cell. TML-6 can exhibit transcriptional activation of the Nrf2 gene in a dose-dependent manner, with the highest activity at a concentration of 1.32 µg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Huh-7 cells Concentration: 0.65, 1.31, 1.96, 2.61, 3.93, 5.24 µg/mL Incubation Time: For 24 hours Result: Reduced the amyloid precursor protein (APP) protein expression level by 60% and decreased the level of phosphorylated NF-κB by about 50% at a dose of 1.96 µg/mL after 24 h treatment. Induced the protein expression level of ApoE by approximately 44% at a dose of 2.62 µg/mL. In Vivo TML-6 (diet; 150 mg/kg/day; for four months) treatment results in significant improvement in learning, suppression of the microglial activation marker Iba-1, and reduction in Aβ in the brain . TML-6 (oral; 150 mg/kg) has a T 1/2 of 1.27 hours, a C max of 35.9 ng/mL and an AUC of 177 ng•hr/mL . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-month-old 3xTg (mutations: APP KM670/671NL , MAPT P301L and PSEN1 M146V ) AD transgenic mice Dosage: 150 mg/kg Administration: Diet; daily; for four months Result: Improved the learning behaviors, significantly suppressed the Aβ levels and Iba-1 expression in the brain of 3xTg AD transgenic mice. Animal Model: SD rats Dosage: 150 mg/kg (Pharmacokinetic Analysis) Administration: Oral Result: Had a T 1/2 of 1.27 hours, a C max of 35.9 ng/mL and an AUC of 177 ng•hr/mL. Form:Solid IC50& Target:NF-κB mTOR

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Diarylheptanoids
    - Subclass Linear diarylheptanoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Diarylheptanoids
Subclass	Linear diarylheptanoids
Intermediate Tree Nodes	Not available
Direct Parent	Curcuminoids
Alternative Parents	Cinnamic acids and derivatives Dimethoxybenzenes Styrenes Phenoxy compounds Anisoles Alkyl aryl ethers N-acyl amines Tertiary carboxylic acid amides Enones Acryloyl compounds Ketones Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Curcumin - Cinnamic acid or derivatives - Dimethoxybenzene - O-dimethoxybenzene - Phenoxy compound - Phenol ether - Styrene - Anisole - Methoxybenzene - Alkyl aryl ether - Benzenoid - N-acyl-amine - Monocyclic benzene moiety - Tertiary carboxylic acid amide - Acryloyl-group - Alpha,beta-unsaturated ketone - Enone - Ketone - Carboxamide group - Carboxylic acid derivative - Ether - Organic nitrogen compound - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organonitrogen compound - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(E)-6-(3,4-dimethoxyphenyl)-3-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]-N,N-diethyl-3-methyl-4-oxohex-5-enamide
INCHI	InChI=1S/C30H37NO7/c1-8-31(9-2)29(34)20-30(3,27(32)16-12-21-10-14-23(35-4)25(18-21)37-6)28(33)17-13-22-11-15-24(36-5)26(19-22)38-7/h10-19H,8-9,20H2,1-7H3/b16-12+,17-13+
InChIKey	UWVCYNXVZRDWSD-UNZYHPAISA-N
Smiles	CCN(CC)C(=O)CC(C)(C(=O)C=CC1=CC(=C(C=C1)OC)OC)C(=O)C=CC2=CC(=C(C=C2)OC)OC
Isomeric SMILES	CCN(C(=O)CC(C(=O)/C=C/C1=CC(=C(C=C1)OC)OC)(C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)C)CC
PubChem CID	72705569
Molecular Weight	523.62

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